- 2901. DNA fingerprinting
- [A procedure in which multilocus band patterns of a DNA sample are generated by digestion of the DNA with restriction enzymes followed by electrophoresis and visualization by hybridization with probes specific for repetitive sequences. In forensic medicine, the probes used are "core" sequences specific for simple tandem-repetitive sequences (minisatellite repeats or VNTRs). The multilocus band patterns, known as DNA fingerprints, are evaluated for similarities with DNA from an individual. ( NCI )] (UMLS (CSP) C0079247) =Molecular Biology Research Technique
| - 2951. DNA Synthesis Factor
- [family of structurally related polypeptides which have important roles in cell development, differentiation, and motility, as well as angiogenesis, neurogenesis, wound healing, and tumor growth. ( CSP )] (UMLS (NCI) C0016026) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=Growth Agents;
|
- 2902. DNA footprinting
- [test for the presence and specificity of DNA binding proteins and their binding sites on DNA, based on their tendency to prevent DNA cleavage by restriction enzymes. ( CSP )] (UMLS (CSP) C0282579) =Molecular Biology Research Technique ;
=chromosome mapping;
| - 2952. DNA Therapy
- [introduction of functioning gene or genes into cells for the purpose of correcting an inborn genetic error, treating a disease by restoring or adding gene expression, or providing a new function to the cell; new genes may be introduced into proliferating cells in vivo (e.g., bone marrow) or in vitro (e.g., fibroblast cultures) and the modified cells transferred to the site where the gene expression is required. ( CSP )] (UMLS (NCI) C0017296) =Therapeutic or Preventive Procedure ;
=Therapeutic Interventions;
genetic manipulation |
- 2903. DNA glycosylase
- [A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the sugar backbone of the DNA molecule. The process called BASE EXCISION REPAIR can be completed by a DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE which excises the remaining RIBOSE sugar from the DNA. ( MSH )] (UMLS (CSP) C0114612) =Amino Acid, Peptide, or Protein; Enzyme
| - 2953. DNA topoisomerase
- [DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. ( MSH )] (UMLS (CSP) C0012920) =Amino Acid, Peptide, or Protein; Enzyme =isomerase;
|
- 2904. DNA gyrase
- [catalyzes the twisting of relaxed, circular DNA into a super coiled state. ( CSP )] (UMLS (CSP) C0949782) =Amino Acid, Peptide, or Protein; Enzyme =isomerase;
| - 2954. DNA topoisomerase (ATP hydrolyzing)
- [Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA. The topoisomerase II reaction appears to involve crossing-over of two DNA segments. Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes. DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation. Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA. (from OMIM 126430 and NCI) ( NCI )] (UMLS (CSP) C0012863) =Amino Acid, Peptide, or Protein; Enzyme
|
- 2905. DNA Helicase
- [nonEC; ATP-driven topoisomerase which unwinds duplex DNA immediately prior to replication or transcription. ( CSP )] (UMLS (NCI) C0920283) DNA unwinding enzyme;
Helicase;
Helicases =Amino Acid, Peptide, or Protein; Enzyme ;
=isomerase;
| - 2955. DNA Topoisomerase I
- [Encoded by human TOP1 Gene (TOPI Family), 765-aa 90.7-kD monomeric DNA Topoisomerase I catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1458146) TOP1;
Topo I;
Topoisomerase (DNA) I;
Topoisomerase I;
Topoisomerase, DNA, I;
Type I DNA Topoisomerase =Amino Acid, Peptide, or Protein; Enzyme |
- 2906. DNA Insertion Elements
- (UMLS (NCI) C0600204) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
| - 2956. DNA Topoisomerase II
- [Encoded by human TOP2A Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa) control DNA topology. TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0256022) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2907. DNA Integration
- [In molecular biology, a recombination event in which a genetic element is inserted. ( NCI )] (UMLS (NCI) C1158478) Integration;
=Genetic Function | - 2957. DNA Topoisomerase II Binding Protein
- [Topoisomerase (DNA) II Binding Protein (TOPBP1), encoded by the TopBP1 gene, is a 173-kD binding protein that interacts with the C-terminal region of topoisomerase II beta. TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands. (From LocusLink) ( NCI )] (UMLS (NCI) C0671110) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 2908. DNA Intercalating Agent
- [Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA. ( MSH )] (UMLS (NCI) C0021717) =Indicator, Reagent, or Diagnostic Aid
| - 2958. DNA Topoisomerase II Binding Protein Gene
- [This gene is involved in DNA replication and apoptosis regulation. ( NCI )] (UMLS (NCI) C1336660) TOPBP1;
TOPBP1 Gene =Gene or Genome ;
|
- 2909. DNA joinase
- [ ] (UMLS (CSP) C0208356) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 2959. DNA Topoisomerase II, 180 kD
- [Encoded by human TOP2B Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Beta isoforms: 2 (1626-aa, 183-kD) and 1 (1621-aa) control DNA topology. TOP2B catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. With 72% similarity in TOP2, TOP2A/B N-terminal ATPase and central breakage/reunion domains are conserved; the C-terminal domains differ markedly. The TOP2B C-terminus contains potential phosphorylation sites. TOP2B is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1504636) DNA Topoisomerase II, Beta Isozyme;
TOP2B;
Topo II Beta;
Topoisomerase (DNA) II Beta (180kD);
Topoisomerase (DNA) II Beta 180kDa;
Topoisomerase II Beta;
Topoisomerase, DNA, II, Beta;
=Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2910. DNA Ligation
- [The joining together of two or more nucleic acid molecules by the action of ligase ( NCI )] (UMLS (NCI) C1155649) =Genetic Function
| - 2960. DNA Topoisomerase III
- [Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5'phosphotyrosine linkage with cleaved DNA). Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom's syndrome, Werner's syndrome, and Rothmund-Thomson syndrome gene products. ( NCI )] (UMLS (NCI) C0114645) =Amino Acid, Peptide, or Protein; Enzyme
|
- 2911. DNA Maintenance
- [DNA Maintenance involves cellular mechanisms that maintain DNA integrity. In many organisms, maintenance of DNA integrity requires not only faithful DNA replication, but also DNA repair and recombination. (NCI) ( NCI )] (UMLS (NCI) C0796351) DNA Stability =Diagnostic Procedure
| - 2961. DNA Topoisomerase III Alpha
- [Expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas), human TOP3 Gene (TOPI/III Family) encodes long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1336768) TOP3A;
TOPO III Alpha;
Topo III-Alpha;
Topoisomerase (DNA) III Alpha;
Topoisomerase III Alpha;
Topoisomerase, DNA, III;
Topoisomerase, DNA, III, Alpha;
=Amino Acid, Peptide, or Protein; Enzyme |
- 2912. DNA mapping
- [ ] (UMLS (CSP) C1328871) =Intellectual Product; ;
| - 2962. DNA Topoisomerase III Beta
- [Expressed as 3 alternative isoforms in testis, heart, skeletal muscle, thymus, kidney, and pancreas by human TOP3B Gene (Topoisomerase I/III Family), Topoisomerase III Beta is a DNA topoisomerase that interacts with DNA helicase SGS1; plays a role in DNA recombination, cellular aging, and maintenance of genome stability; and controls/alters DNA topology by relieving torsional stress in negatively supercoiled DNA during transcription. TOP3B catalyzes transient ATP-independent breaking and rejoining of DNA single-strands. Alternative C-terminal splicing results in three transcript variants that have distinct tissue specificity. (NCI) ( NCI )] (UMLS (NCI) C1097583) TOP3B;
Topoisomerase III Beta;
Topoisomerase IIIB =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2913. DNA marker
- [ ] (UMLS (CSP) C0012872) =Laboratory or Test Result; Sign or Symptom
| - 2963. DNA Topoisomerase Inhibitors
- [A family of anticancer drugs. The topoisomerase enzymes are responsible for the arrangement and rearrangement of DNA in the cell and for cell growth and replication. Inhibiting these enzymes may kill cancer cells or stop their growth. ( NCI )] (UMLS (NCI) C0598317) =Pharmacologic Substance
|
- 2914. DNA methylation
- [addition of methyl groups to DNA; DNA methyltransferases (DNA methylases) perform this reaction using s-asenosylmethionine as the methyl group donor. ( CSP )] (UMLS (CSP) C0376452) =Genetic Function =nucleic acid methylation;
| - 2964. DNA Topoisomerase IV
- [Topoisomerase IV belongs to type II topoisomerase family (includes bacterial DNA gyrase, and eukaryotic topo II). The type II enzymes are multisubunit proteins, and require ATP for overall catalytic activity. Topoisomerase IV (is a potent decatenase) is required to untangle daughter chromosomes following replication. ( NCI )] (UMLS (NCI) C0082329) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2915. DNA Methyltransferases
- [An enzyme that binds to specific DNA sequences and protects the nucleotides therein. The nucleotide sequence contains a cognate recognition sequence that is protected from digestion by exonucleases. The enzyme protects the sequence by methylation on an adenine or cytosine residue. If the DNA is left unprotected, it will be proteolytically cleaved by host endonucleases. ( NCI )] (UMLS (NCI) C0012873) =Amino Acid, Peptide, or Protein; Enzyme
| - 2965. DNA transfer to foreign host
- [ ] (UMLS (CSP) C0599565) =Genetic Function; Molecular Biology Research Technique
|
- 2916. DNA Mismatch Repair Gene Homolog
- [Associated with colon, endometrial, and stomach cancers, DNA Mismatch Repair Protein PMS2, a 97-kD protein encoded by the ubiquitously expressed PMS2 Gene (MUTL/HEXB family) is involved with MSH2 and MLH1 in mismatch repair of dinucleotide and trinucleotide sequences. PMS2 is part of the BASC genome surveillance complex. MSH2 and MLH1 interact with PMS1, PMS2, and MSH6. Essential for repair of replication slippage errors, PMS2 is a cloned gene for Turcot syndrome and Hereditary Non-Polyposis Colon Cancer. Transcribed from the opposite strand, JTV1 overlaps PMS2. (From SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1333235) DNA Mismatch Repair Protein PMS2;
PMS2 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2966. DNA Tumor Virus
- [A virus which uses DNA to code its genome and causes tumors in animals. ( NCI )] (UMLS (NCI) C0012917) =Virus ;
|
- 2917. DNA Mismatch Repair Protein MLH3
- [DNA Mismatch Repair Protein MLH3, encoded by the MLH3 gene, is ubiquitously expressed in various tissues and two isoforms are produced by alternative splicing. MLH3 interacts with MLH1 and shares the same interacting region on MLH1 with PMS1 and PMS2. The balance of these three competing MLH1 partners might be important in the repair of mismatches in DNA. Malfunction of the mismatch repair system results in a mutator phenotype, which is manifested as microsatellite instability (MSI). MSI is often divided into 2 forms: MSI-high (MSI-H) and MSI-low (MSI-L), based quantitatively on the observed frequency of genomic mutations. An appreciable frequency of somatic MLH3 mutations in MSI-H tumors is consistent with a possible role for this gene in the progression of colorectal cancer tumorigenesis. Germline mutations of the MLH3 gene may also play a role in hereditary nonpolyposis colorectal cancer (NCI) ( NCI )] (UMLS (NCI) C1333233) MLH3;
MutL Protein Homolog 3 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2967. DNA Vaccine
- [DNA vaccines are used in vaccination in way that differs from those are designed to be inserted into germ line of vaccines. Therefore, this is a vaccine not a therapy for modifying genetic information (gene therapy). Direct innoculation of DNA vaccine causes expression of the recombinant DNA by cells in the inoculated host. This expression of the recombinant DNA produces protein of interest that promotes antibody, cytolytic T cell and protective immune responses. ( NCI )] (UMLS (NCI) C0376613) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance; Immunologic Factor
|
- 2918. DNA Mismatch Repair Protein MSH2
- [DNA Mismatch Repair Protein MSH2, encoded by the MSH2 gene (MUTS family) is a postreplication mismatch repair homologue of mutS (E. coli), which binds to insertion-deletion looped DNA mismatches. MutS homologues have ATPase activity and contain a conserved DNA binding helix-turn-helix domain associated with an adenine nucleotide/magnesium-binding Walker-A motif that may regulate mismatch binding as a molecular switch. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH2 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. MSH2 alteration is associated with DNA instability. (From SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1333234) MSH2;
MutS Homolog 2 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2968. DNA virus
- [virus whose genome consists of DNA. ( CSP )] (UMLS (CSP) C0012923) =Virus ;
=virus;
=Adenoviridae;
Hepadnaviridae;
herpes virus;
Parvoviridae;
pox virus;
Baculoviral;
Papovaviridae |
- 2919. DNA Mismatch Repair Protein MSH6
- [The G/T Binding Protein (GTBP), encoded by the MSH6 gene, forms Mismatch-Binding Factor with MSH2. Associated with colon, endometrial, and stomach cancers, the MSH6 Gene is a cloned gene for Hereditary Non-Polyposis Colon Cancer. GTBP contains a PWWP domain, binds to G/T mismatches, is required for base/base and single-nucleotide insertion-deletion repairs, and increases the proficiency of two-four nucleotide insertion-deletion repair. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH6 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. (From SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0299348) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2969. DNA-Activated Protein Kinase Catalytic Subunit
- [Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), encoded by the PRKDC gene, is a nuclear protein serine/threonine kinase of a multiprotein complex DNA-dependent protein kinase (DNA-PK). Two protein isoforms are produced by alternative splicing and binds DNA for catalysis. PRKDC relies on the heterodimer Ku70/Ku80 autoantigen, the DNA-binding DNA-PK component, to direct it to DNA double-stranded breaks for other discontinuities in the DNA double helix and trigger its kinase activity. PRKDC is critical for repair of DNA double strand breaks via the nonhomologous DNA end joining, telomere maintenance via telomere capping, innate immune response via V(D)J recombination (where V is variable, D is diversity, and J is joining) as well as transcriptional regulation via p53, the site-specific recombination process in developing B and T lymphocytes to generate the variable regions of immunoglobulin and T cell receptor genes. ( NCI )] (UMLS (NCI) C0212694) =Amino Acid, Peptide, or Protein; Enzyme
|
- 2920. DNA Mismatch Repair Protein PMS1
- [DNA Mismatch Repair Protein PMS1, encoded by the PMS1 gene, is implicated, with MSH2 and MLH1, in mismatch repair of dinucleotide and trinucleotide sequences. A cloned gene for Hereditary Non-Polyposis Colon Cancer, the PMS1 Gene (MUTL/HEXB family) at 2q31-q33 is associated with colon, endometrial, and stomach cancers. Human PMSL genes exhibit homology to bacterial mutL genes and yeast PMS1 gene. (From SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0258380) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 2970. DNA-Binding Protein Inhibitor ID-2
- [Encoded by human ID2 Gene (bHLH/ID Family) and expressed in most fetal tissues, 134-aa nuclear ID2 Protein is an HLH protein, lacking a basic DNA-binding domain, that heterodimerizes through the HLH domain with, and inhibits DNA binding of, other bHLH transcription factors in a dominant-negative manner by suppressing their heterodimerization with functional partners. ID proteins promote cell proliferation and likely influence of cell differentiation. ID2 inhibits antiproliferative effects of active, hypophosphorylated RB, p107, and p130 tumor suppressor proteins, allowing cell cycle progression. By inactivating RB, ID2 also abolishes p16 growth inhibitory protein function. During normal cell cycle, RB inhibits ID2 action on its targets. MYC activates ID2 transcription. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0123156) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 2921. DNA Modification
- [Biological processes that involve adding/removing chemical moieties to/from DNA, including methylation, phosphorylation, dephosphorylation, etc. occurring either in vivo or in vitro. ( NCI )] (UMLS (NCI) C1158479) DNA Modification Process;
=Genetic Function | - 2971. DNA-Binding Transcriptional Activator
- [Expressed in fetal brain, lung, liver, and kidney by human NCYM Gene, 109-aa 12-kDa DNA-Binding Transcriptional Activator NCYM contains a helix-loop-helix motif and a basic region. NCYM appears to function as a DNA-binding protein during normal fetal development and is implicated in the pathogenesis of human tumors. The NCYM transcription unit is located on the opposite strand to NMYC, with extensive overlap between the 5-prime ends of the two units. NMYC and NCYM appear to be coregulated under basal growth conditions and in response to retinoic acid. (NCI) ( NCI )] (UMLS (NCI) C1333228) DNA-Binding Transcriptional Activator NCYM;
MYCNOS;
NCYM;
NCYM Protein;
V-Myc Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Opposite Strand;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2922. DNA Molecular Biology
- [study of biological processes at the molecular level, including membrane biochemistry, cytoskeleton biochemistry, and structural biology in addition to molecular genetics (see NTs and RTs). ( CSP )] (UMLS (NCI) C0026376) =Biomedical Occupation or Discipline ;
=Biologic;
=computer assisted sequence analysis;
structural biology;
molecular biology information system;
proteomics;
molecular assembly;
small molecule;
| - 2972. DnaJ Homolog Subfamily B Member 4 Gene
- [This gene plays a role in both transcriptional regulation and cellular viability. ( NCI )] (UMLS (NCI) C1423025) DNAJB4;
DNAJB4 Gene =Gene or Genome |
- 2923. DNA nucleotidyltransferase
- [Enzymes that catalyze the incorporation of deoxyribonucleotides into a chain of DNA. EC 2.7.7.-. ( MSH )] (UMLS (CSP) C0012882) =Amino Acid, Peptide, or Protein; Enzyme
| - 2973. DNase protection assay
- [ ] (UMLS (CSP) C0598310) =Molecular Biology Research Technique ;
|
- 2924. DNA Ploidy Analysis
- [A test used to measure nuclear deoxyribonucleic acid content (ploidy or multiplicity of the basic number of chromosomes) in a cell. ( NCI )] (UMLS (NCI) C0796359) =Diagnostic Procedure
| - 2974. DNAX-Activation Protein 12
- [Encoded by human TYROBP Gene, 113-aa 12-kDa (precursor) disulfide-linked homodimeric Tyr-phosphorylated TYRO Protein Tyrosine Kinase Binding Protein is a type I transmembrane polypeptide containing a cytoplasmic ITAM motif that may act as an activating signal transduction element in bone modeling, brain myelination, and inflammation. TYROBP associates with KIR family membrane glycoproteins without a cytoplasmic ITIM; KIR/TYROBP complexes promote cellular activation. TYROBP interacts with SIRPB1 and may bind TCR zeta chain-associated ZAP-70 kinase and SYK tyrosine kinase. (NCI) ( NCI )] (UMLS (NCI) C1336693) TYRO Protein Tyrosine Kinase Binding Protein;
TYROBP;
=Amino Acid, Peptide, or Protein; Immunologic Factor |
- 2925. DNA primase
- [nonEC; enzyme which synthesizes a short RNA primer to initiate DNA- directed DNA biosynthesis. ( CSP )] (UMLS (CSP) C0058594) =Amino Acid, Peptide, or Protein; Enzyme =EC 2.7.7;
| - 2975. DNET
- [A benign glial-neuronal neoplasm. It is usually supratentorial, located, generally, in the cortex and occurs in children and young adults with a long-standing history of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal element', characterized by columns, made up of bundles of axons, oriented perpendicularly to the cortical surface. (Adapted from WHO.) ( NCI )] (UMLS (NCI) C1266177) DNT;
Dysembryoplastic Neuroepithelial Neoplasm;
Dysembryoplastic Neuroepithelial Tumor =Neoplastic Process |
- 2926. DNA Primase 1
- [Encoded by human PRIM1 Gene (Eukaryotic Primase Small Subunit Family), 420-aa 49-kDa Primase Polypeptide 1 is the small subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. Zinc bound to a PRIM1 zinc knuckle motif appears be involved in sequence recognition and binding of ssDNA. (NCI) ( NCI )] (UMLS (NCI) C1335494) DNA Primase 49kDa Subunit;
DNA Primase Small Subunit;
DNA Primase Subunit 48;
PRIM1;
Primase p49 Subunit;
Primase Polypeptide 1;
Primase, p49 Subunit =Amino Acid, Peptide, or Protein; Enzyme | - 2976. DO
- [A country comprising the eastern two-thirds of the island of Hispaniola, between the Caribbean Sea and the North Atlantic Ocean, east of Haiti. (NCI) ( NCI )] (UMLS (NCI) C0013014) =Geographic Area
|
- 2927. DNA primer
- [short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptase to start copying the adjacent sequences of mRNA. ( CSP )] (UMLS (CSP) C0206416) =Nucleic Acid, Nucleoside, or Nucleotide =Oligo;
| - 2977. Do at bedside or portable (may be used with other codes)
- (UMLS (HL7) C1549560) =Idea or Concept =Processing priority;
|
- 2928. DNA probe
- [A piece of DNA that has been labeled, usually radioactively or with a fluorescent dye, which is used in hybridization studies. Applications include Northern and Southern blots, in situ hybridization techniques, and diagnostic tests. DNA probes can be highly specific or degenerate. ( NCI )] (UMLS (CSP) C0012893) =Nucleic Acid, Nucleoside, or Nucleotide; Indicator, Reagent, or Diagnostic Aid
| - 2978. Do NOT inform patient
- (UMLS (HL7) C1549023) =Intellectual Product =Inform person code;
|
- 2929. DNA Proofreading
- [A function of the mismatch repair (MMR) system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication. This function is critically dependent on the assembly of multimeric complexes involved in mismatch recognition and signal transduction to downstream repair events. ( NCI )] (UMLS (NCI) C1155660) DNA Replication Proofreading;
Proofreading of DNA Replication =Genetic Function | - 2979. Do not resuscitate
- (UMLS (HL7) C1547313) =Intellectual Product =Advance Directive Code;
|
- 2930. DNA purification
- [ ] (UMLS (CSP) C0872148) =Laboratory Procedure ;
| - 2980. Do not shake
- (UMLS (HL7) C1550123) =Idea or Concept =Special Handling Code;
|
- 2931. DNA rearrangement
- [covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins. ( CSP )] (UMLS (CSP) C0017287) =Genetic Function ;
=immunogenetics;
DNA Recombination;
Molecular Genetics;
| - 2981. do not shake
- [Do not shake ( HL7V3.0 )] (UMLS (HL7) C1550586) =Idea or Concept =EntityHandling;
|
- 2932. DNA Recombination
- [natural process of exchange of DNA between two homologous chromosomes during mitosis; do not confuse with RECOMBINANT DNA, which applies to artificial DNA constructs. ( CSP )] (UMLS (NCI) C0034865) =Genetic Function =Molecular Genetics;
=genetic crossing over;
gene conversion;
DNA rearrangement | - 2982. Doberman
- [The Doberman Pinscher is a muscular and very powerful dog. Its hard, short-haired, close-fitting coat comes in black, black and tan, blue-gray, red, fawn and white. The hair is short, thick and tight to its body. The ears are usually cropped and then taped for a couple of months to make them stand up. If left natural the ears develop somewhat like a hound. Height: 24-28 inches (61-71 cm.) Weight: 66-88 pounds (30-40 kg.) ( NCI )] (UMLS (NCI) C0324358) =Mammal
|
- 2933. DNA redundancy
- [ ] (UMLS (CSP) C0598498) =Genetic Function ;
| - 2983. Dobupride
- (UMLS (NCI) C0386741) =Organic Chemical; Pharmacologic Substance ;
|
- 2934. DNA Repair Deficiency
- (UMLS (NCI) C0268134) =Disease or Syndrome ;
| - 2984. dobutamine
- [beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia; it is proposed as a cardiotonic after myocardial infarction or open heart surgery. ( CSP )] (UMLS (CSP) C0012963) =Organic Chemical; Pharmacologic Substance ;
=Cardioprotective Agent;
catecholamine;
Phenethylamines;
[AU100] SYMPATHOMIMETICS (ADRENERGICS) =DOBUTAMINE HYDROCHLORIDE |
- 2935. DNA Repair Endonuclease
- [DNA Repair Endonucleases specifically catalyze the hydrolysis of interior DNA phosphodiester bonds during correction of errors in DNA structure and sequence to protect genetic information against chemical, radiation or spontaneous damage and against replication errors, and to restore DNA to its original state. ( NCI )] (UMLS (NCI) C1333236) =Amino Acid, Peptide, or Protein; Enzyme
| - 2985. DOBUTAMINE TARTRATE
- [The tartrate salt form of dobutamine, a synthetic catecholamine with sympathomimetic activity. Dobutamine primarily binds to and stimulates beta-1-adrenergic receptors located in the myocardium. As a result, it leads to a positive inotropic effect and increases in cardiac output. ( NCI )] (UMLS (NCI) C0887392) =Organic Chemical; Pharmacologic Substance ;
|
- 2936. DNA Repair Gene
- [DNA Repair Genes encode DNA Repair Proteins, involved in enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage. (NCI) ( NCI )] (UMLS (NCI) C1333237) =Gene or Genome ;
| - 2986. Dobutrex
- (UMLS (NCI) C0012964) =Organic Chemical; Pharmacologic Substance ;
|
- 2937. DNA repair methyltransferase
- [ ] (UMLS (CSP) C0872149) =Amino Acid, Peptide, or Protein; Enzyme
| - 2987. DOC-1R
- [Ubiquitous 126-aa 13-kDa Tumor Suppressor Deleted In Oral Cancer-Related 1 protein is encoded by human DOC-1R Gene (DOC1 Family). (NCI) ( NCI )] (UMLS (NCI) C0910618) DOC-1R Protein;
Tumor Suppressor Deleted in Oral Cancer-Related 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2938. DNA Repair Protein
- [Any of the proteins involved in the enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage. ( NCI )] (UMLS (NCI) C1366764) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 2988. Docarpamine
- (UMLS (NCI) C0075755) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 2939. DNA Repair Protein RAD51 Homolog 3
- [Encoded by human RAD51C Gene (RECA Family, RAD51 Subfamily), the 376-amino acid 42 kD RAD51 Homolog C is a probable nuclear protein likely involved in meiotic recombination and repair of damaged DNA. Highest expression is observed in testis, heart muscle, spleen, and prostate. RAD51 family members are strand-transfer proteins thought involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C protein interacts strongly with RAD51B and moderately with XRCC3 DNA repair proteins, but not with itself. The RAD51C/XRCC3 complex binds single-stranded, but not duplex, DNA. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1448265) RAD51 Homolog C;
RAD51C;
RAD51L2;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2989. Docetaxel Anhydrous
- [The anhydrous form of docetaxel, a semisynthetic side-chain analogue of paclitaxel with antineoplastic property. Docetaxel binds specifically to the beta-tubulin subunit of microtubules and thereby antagonizes the disassembly of the microtubule proteins. This results in the persistence of aberrant microtubule structures and results in cell-cycle arrest and subsequent cell death. ( NCI )] (UMLS (NCI) C0771375) DOCETAXEL, ANHYDROUS =Organic Chemical; Pharmacologic Substance
|
- 2940. DNA Repair Protein RAD54-Like
- [RAD54-Like Protein (RAD54L), encoded by the RAD54L gene, belongs to the DEAD-like helicase superfamily. RAD54L plays a role in homologous recombination related repair of DNA double-strand breaks. The binding of RAD54L to double-strand DNA induces a DNA topological change, which facilitates homologous DNA paring and stimulates DNA recombination. (From LocusLink) ( NCI )] (UMLS (NCI) C0534064) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 2990. Docetaxel/DN-101
- (UMLS (NCI) C1328170) =Therapeutic or Preventive Procedure; ;
|
- 2941. DNA Repair Protein XRCC1
- [X-Ray Repair Cross Complementing Protein 1 (XRCC1), encoded by the XRCC1 gene, functions in the repair of single-strand DNA breaks and sister chromatid exchange. With no catalytic activity, XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively, after treatment with ionizing radiation and alkylating agents. In the initial step of processing damaged DNA ends, XRCC1 stimulates the DNA kinase and DNA phosphatase activities of PNK at damaged DNA termini, thus accelerating the overall repair reaction in mammalian single-strand break repair pathway. XRCC1 is also required for full activity of LIG3 in rejoining of broken DNA strands. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. ( NCI )] (UMLS (NCI) C0250029) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2991. Docetaxel/Doxorubicin
- (UMLS (NCI) C0392970) =Therapeutic or Preventive Procedure ;
|
- 2942. DNA Repair Protein XRCC2
- [X-Ray Repair Cross Complementing Protein 2, encoded by the XRCC2 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC2 is essential for the efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. XRCC2 also may have a role in meiosis. (from OMIM 600375, LocusLink 7516 and NCI) ( NCI )] (UMLS (NCI) C0676905) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2992. Docetaxel/Doxorubicin HCl Liposome
- (UMLS (NCI) C0678063) =Therapeutic or Preventive Procedure ;
|
- 2943. DNA Repair Protein XRCC3
- [X-Ray Repair Cross Complementing Protein 3 (XRCC3), encoded by the XRCC3 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI) ( NCI )] (UMLS (NCI) C1337025) X-Ray Repair Cross Complementing Protein 3;
X-Ray-Repair, Complementing Defective, Repair In Chinese Hamster;
XRCC3;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2993. Docetaxel/Doxorubicin Hcl Liposome/Trastuzumab
- (UMLS (NCI) C0879443) =Therapeutic or Preventive Procedure ;
|
- 2944. DNA Repair Protein XRCC9
- [Expressed in testis, thymus, and lymphoblasts by human FANCG Gene, 622-aa 68.5-kD DNA Repair Protein XRCC9 contains an N-terminal leucine-zipper motif and belongs to a multisubunit nuclear protein complex with PHF9, FANCA, FANCC, FANCE, and FANCF. Implicated in interstrand DNA cross-link repair and in maintenance of normal chromosome stability, FANCG may operate in postreplication repair or in a cell cycle checkpoint. (NCI) ( NCI )] (UMLS (NCI) C1333238) FANCG;
Fanconi Anemia Complementation Group G;
Fanconi Anemia Group G Protein;
X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 9;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2994. Docetaxel/Doxorubicin/Oblimersen
- (UMLS (NCI) C1327995) =Therapeutic or Preventive Procedure ;
|
- 2945. DNA replication fork
- [DNA replication is a process that allows two new double helixes of DNA to be created from one double helix. During replication, Y-shaped regions of replicating DNA molecules are mobilized, where the enzymes replicating a DNA molecule bind to an untwisted, single DNA strand. This Y-shaped region is referred to as a replication fork. Bacteria and viruses only process one replication fork at a time, while eukaryotic DNA has many replication forks moving along DNA strands at the same time. ( NCI )] (UMLS (CSP) C0598316) =Genetic Function
| - 2995. Docetaxel/Doxorubicin/Tamoxifen
- (UMLS (NCI) C0796522) DOX/TMX/TXT =Therapeutic or Preventive Procedure
|
- 2946. DNA Replication Initiation
- [DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. (from MedLine 11395402) ( NCI )] (UMLS (NCI) C1155650) Replication Initiation;
=Genetic Function | - 2996. Docetaxel/Epirubicin
- (UMLS (NCI) C0392962) =Therapeutic or Preventive Procedure ;
|
- 2947. DNA Replication Licensing Factor MCM6
- [Widely expressed by E2F-regulated human MCM6 Gene (MCM Family), 821-aa 93-kDa DNA Replication Licensing Factor MCM6 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complex during G1, detaches from it during S phase, and prevents over-replication. Repressed in quiescent cells, MCM6 is rapidly induced at G1/S by growth factor stimulation; protein level peaks at G1/S. A stable MCM2/4/6/7 complex exhibits DNA unwinding ATPase/DNA helicase activity involved in replication initiation. MCM2/4/6/7 phosphorylation by CDC2 kinase reduces helicase activity. Hexameric MCM2-7 complex is a key element of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. (NCI) ( NCI )] (UMLS (NCI) C1333240) MCM6;
Minichromosome Maintenance Protein 6;
MIS5;
P105MCM;
=Amino Acid, Peptide, or Protein; Biologically Active Substance | - 2997. Docetaxel/Epirubicin/Filgrastim
- (UMLS (NCI) C0392963) =Therapeutic or Preventive Procedure ;
|
- 2948. DNA replication origin
- [position along a molecule at which DNA replication begins. ( CSP )] (UMLS (CSP) C0596456) =Genetic Function =DNA biosynthesis;
| - 2998. Docetaxel/Epirubicin/Pegfilgrastim
- (UMLS (NCI) C1328016) =Therapeutic or Preventive Procedure; ;
|
- 2949. DNA sequence
- [The sequence of nucleotide residues along a DNA chain. ( NCI )] (UMLS (CSP) C0162326) =Nucleotide Sequence; Nucleic Acid, Nucleoside, or Nucleotide
| - 2999. Docetaxel/Erlotinib
- (UMLS (NCI) C1327739) =Therapeutic or Preventive Procedure ;
|
- 2950. DNA strand break
- [A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one or in both strands of a DNA molecule. ( NCI )] (UMLS (CSP) C0872150) =Cell or Molecular Dysfunction ;
| - 3000. Docetaxel/Estramustine
- (UMLS (NCI) C0677761) =Therapeutic or Preventive Procedure
|
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