DNA Topoisomerase II, 180 kD
[Encoded by human TOP2B Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Beta isoforms: 2 (1626-aa, 183-kD) and 1 (1621-aa) control DNA topology. TOP2B catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. With 72% similarity in TOP2, TOP2A/B N-terminal ATPase and central breakage/reunion domains are conserved; the C-terminal domains differ markedly. The TOP2B C-terminus contains potential phosphorylation sites. TOP2B is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1504636DNA Topoisomerase II, Beta Isozyme
TOP2B
Topo II Beta
Topoisomerase (DNA) II Beta (180kD)
Topoisomerase (DNA) II Beta 180kDa
Topoisomerase II Beta
Topoisomerase, DNA, II, Beta
TOP2B
Topo II Beta
Topoisomerase (DNA) II Beta (180kD)
Topoisomerase (DNA) II Beta 180kDa
Topoisomerase II Beta
Topoisomerase, DNA, II, Beta
- Amino Acid, Peptide, or Protein
- Enzyme
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