DNA Topoisomerase I
[Encoded by human TOP1 Gene (TOPI Family), 765-aa 90.7-kD monomeric DNA Topoisomerase I catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1458146TOP1
Topo I
Topoisomerase (DNA) I
Topoisomerase I
Topoisomerase, DNA, I
Type I DNA Topoisomerase
Topo I
Topoisomerase (DNA) I
Topoisomerase I
Topoisomerase, DNA, I
Type I DNA Topoisomerase
- Amino Acid, Peptide, or Protein
- Enzyme
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
