DNA-Binding Protein Inhibitor ID-2
[Encoded by human ID2 Gene (bHLH/ID Family) and expressed in most fetal tissues, 134-aa nuclear ID2 Protein is an HLH protein, lacking a basic DNA-binding domain, that heterodimerizes through the HLH domain with, and inhibits DNA binding of, other bHLH transcription factors in a dominant-negative manner by suppressing their heterodimerization with functional partners. ID proteins promote cell proliferation and likely influence of cell differentiation. ID2 inhibits antiproliferative effects of active, hypophosphorylated RB, p107, and p130 tumor suppressor proteins, allowing cell cycle progression. By inactivating RB, ID2 also abolishes p16 growth inhibitory protein function. During normal cell cycle, RB inhibits ID2 action on its targets. MYC activates ID2 transcription. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0123156- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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