- 1. (+)-DX 52-1
- [An anticancer drug that belongs to the family of drugs called antitumor antibiotics. It is an anthracycline. ( NCI )] (UMLS (NCI) C0294165) =Organic Chemical; Pharmacologic Substance ;
| - 51. 1,25-Dihydroxyvitamin D3 Receptor
- [use for receptors of any of the D vitamins. ( CSP )] (UMLS (NCI) C0108082) =Amino Acid, Peptide, or Protein; Receptor =vitamin receptor;
|
- 2. (+-)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate
- [The nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. ( NCI )] (UMLS (NCI) C0144004) =Organic Chemical; Pharmacologic Substance ;
=SULCONAZOLE;
=SULCONAZOLE NITRATE 1 % | - 52. 1,2:15,16-Diepoxy-4,7,10, 13-tetraoxahexadecane
- [Alkylating antineoplastic agent used especially in bladder neoplasms. It is toxic to hair follicles, gastro-intestinal tract, and vasculature. ( MSH )] (UMLS (NCI) C0015039) =Organic Chemical; Pharmacologic Substance ;
|
- 3. (+-)-15-Deoxyspergualin
- [A derivative of the antitumor antibiotic spergualin with immunosuppressant activity. Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04) ( NCI )] (UMLS (NCI) C0284559) =Organic Chemical; Pharmacologic Substance ;
| - 53. 1,3 diazine
- [ ] (UMLS (CSP) C0034284) =Organic Chemical ;
|
- 4. (-)-.DELTA.9-Tetrahydrocannabinol
- [A synthetic pill form of delta-9-tetrahydrocannabinol (THC), an active ingredient in marijuana that is used to treat nausea and vomiting associated with cancer chemotherapy. ( NCI )] (UMLS (NCI) C0039663) =Organic Chemical; Pharmacologic Substance ;
=[GA700] ANTIEMETICS;
cannabinoid =NABILONE;
DRONABINOL 10 MG;
DRONABINOL 2.5 MG;
DRONABINOL 5 MG;
| - 54. 1,3-Diamino-4-methoxybenzene Sulphate
- [A synthetic, off-white to violet solid that is soluble in water and ethanol. It is used primarily as a component of oxidizing 'permanent' hair- and fur-dye formulations. 2,4-Diaminoanisole sulfate is also used as an intermediate in the production of C.I. Basic Brown 2, a dye commonly used in numerous consumer products. The primary routes of potential human exposure to 2,4-diaminoanisole sulfate are dermal contact and inhalation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0126603) =Organic Chemical; Pharmacologic Substance
|
- 5. (-)-2'-Deoxy-5-fluoro-3'-thiacytidine
- (UMLS (NCI) C0877876) =Nucleic Acid, Nucleoside, or Nucleotide
| - 55. 1,3-Diamino-4-methylbenzene
- [A synthetic, colorless to brown crystalline solid that is soluble in water, ethanol, ether and benzene. It is used primarily as an intermediate in the production of toluene diisocyanate, which is used to produce polyurethane. Small amounts of 2,4-diaminotoluene are also used to produce dyes for textiles, leathers, furs, and wood and biological stains. When heated to decomposition, it emits toxic fumes of nitrogen oxides. The primary routes of potential human exposure to 2,4-diaminotoluene are dermal contact and inhalation. Contact with this chemical can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0045479) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 6. (1,1-Dimethylethyl)-4-methoxyphenol
- [A white, waxy solid mixture of 2- and 3-Tert-butyl-4-hydroxyanisole with a faint aromatic odor. Butylated Hydroxyanisole is a widely used synthetic antioxidant in foods, cosmetics and pharmaceuticals mainly to preserve fats and oils. Butylated Hydroxyanisole is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0006506) =Organic Chemical; Pharmacologic Substance
| - 56. 1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl
- [A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04) ( NCI )] (UMLS (NCI) C0075019) =Organic Chemical; Pharmacologic Substance ;
|
- 7. (3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) Methanone
- [A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen. ( NCI )] (UMLS (NCI) C0077238) =Organic Chemical; Pharmacologic Substance ;
| - 57. 1,3-Diaziridino-2,4,6-Triaza-1,3,5,5-Tetraaminomethyl-1,3,5-Triphosphorin
- [An aziridinyl-substituted cyclophosphazene and a putrescence derivative that may cause DNA cross-linkage. (NCI04) ( NCI )] (UMLS (NCI) C0043914) =Organic Chemical; Pharmacologic Substance ;
|
- 8. (6-D-(2-Naphthyl)alanine)LHRH Acetate
- (UMLS (NCI) C0700477) =Amino Acid, Peptide, or Protein; Pharmacologic Substance =6-D-(2-naphthyl)alanyl-GnRH;
=NAFARELIN ACETATE 2 MG/ML;
| - 58. 1,3-Dichloro-1-propene
- [A synthetic, flammable, colorless liquid that is relatively insoluble in water and soluble in ether, acetone, toluene and benzene. It is used as an intermediate in the manufacture of 3,3-dichloro-1-propene and other pesticides. When heated to decomposition, 1,3-dichloropropene produces toxic fumes of hydrochloric acid and other chlorinated compounds. The primary routes of exposure are inhalation of vapors, dermal contact, and ingestion of contaminated foods and drinking water. Acute exposure can cause irritation of the eyes, skin and mucous membranes. Inhale a low concentration of vapors can result in irritation of the respiratory tract and central nervous system depression. Breathing higher vapor concentrations of this substance may cause coughing, breathing difficulties, substernal pain and extreme respiratory distress. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043918) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 9. (Dichloromethylene)bisphosphonic Acid
- [A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activity. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption. ( NCI )] (UMLS (NCI) C0012081) =Organophosphorus Compound; Pharmacologic Substance
| - 59. 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
- [1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl) -amino) ethyl)amino) anthraquinone; cytotoxic compound with potentially therapeutic antitumor activity in breast cancer, lymphoma, and leukemia. ( CSP )] (UMLS (NCI) C0026259) =Organic Chemical; Pharmacologic Substance ;
=anthracene;
Anthracenedione;
[AN000] ANTINEOPLASTICS;
=1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride |
- 10. (Diethylenetriamine)pentaacetic acid
- [An edetate and a chelating agent used in preparing radiopharmaceuticals. Pentetic acid (DTPA) has strong affinity for iron but also shows affinities for other heavy metals, thereby is used in the treatment of iron-storage disease and poisoning from heavy and radioactive metals. DTPA may chelate metallic moieties of unbound, extracellular radioimmunotherapeutics, thereby aggregating radioimmunotherapeutics locally to higher concentrations, and improving tumor cell radiocytotoxicity, while sparing normal tissues from the radiocytotoxic effects. In addition, DTPA is used in radioimaing procedures when complexes with radioisotopes, ex., Tc 99m or In 111. ( NCI )] (UMLS (NCI) C0013254) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =Acetic Acids;
Polyamines;
[DX201] IMAGING AGENTS (IN VIVO) RADIOPHARMACEUTICALS;
Inactive Ingredient Preparations =Gadolinium DTPA;
DIETHYLENETRIAMINE PENTAACETIC ACID 0.15 MG/ML;
PENTETIC ACID 10 MG;
| - 60. 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride
- [The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. ( NCI )] (UMLS (NCI) C0700458) =Organic Chemical; Pharmacologic Substance =Mitoxantrone;
=MITOXANTRONE HYDROCHLORIDE 2 MG/ML |
- 11. (DMSO)
- [highly polar organic liquid, that is used widely as a chemical solvent; because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals; it is also used to protect tissue during cryopreservation; dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. ( CSP )] (UMLS (NCI) C0012403) =Organic Chemical; Pharmacologic Substance ;
=Sulfoxides;
sulfoxide;
Inactive Ingredient Preparations;
=DIMETHYL SULFOXIDE 50 %;
DIMETHYL SULFOXIDE 100 %;
| - 61. 1,3-Diisocyanatomethylbenzene
- [A synthetic mixture of the 2,4- and 2,6-isomers is a volatile, colorless to pale yellow liquid that is soluble in many organic solvents. These isomers are used primarily in the synthesis of polyurethane foams. When heated to decomposition, toluene diisocyanate emits toxic fumes of cyanides and nitrogen oxides. Exposure of humans to toluene diisocyanate causes tissue irritation, especially to the mucous membranes, and can produce severe respiratory problems. These isomers are reasonably anticipated to be human carcinogens. (NCI05) ( NCI )] (UMLS (NCI) C0205976) =Organic Chemical; Hazardous or Poisonous Substance
|
- 12. *Difference
- [A change in or difference between; usually represented by the 4th letter of the greek alphabet. ( NCI )] (UMLS (HL7) C1705241) Change;
Delta;
Difference =Quantitative Concept =Kind of quantity;
| - 62. 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine
- [A succinimide with anticonvulsant properties. Although the exact mechanism of action of methsuximide is unclear, it is thought to increase the seizure threshold and suppress the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex and elevation of the threshold of the CNS to convulsive stimuli, probably due to direct modification of membrane function in excitable cells and/or alteration of chemically mediated neurotransmission. ( NCI )] (UMLS (NCI) C0109002) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
succinimide =METHSUXIMIDE 150 MG;
METHSUXIMIDE 300 MG;
|
- 13. *Dilution Factor (Titer)
- [Concentration of a solution as determined by titration. ( NCI )] (UMLS (HL7) C0475208) =Quantitative Concept =Kind of quantity;
| - 63. 1,3-Dimethylxanthine Monohydrate
- (UMLS (NCI) C0304443) =Organic Chemical; Pharmacologic Substance
|
- 14. .delta.-Aminolevulinic acid hydrochloride
- [The hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects. ( NCI )] (UMLS (NCI) C0876231) 5-Amino-4-oxopentanoic Acid HCl;
5-Amino-4-oxopentanoic Acid Hydrochloride;
Aminolevulinic Acid HCl;
AMINOLEVULINIC ACID HYDROCHLORIDE;
Delta-Aminolevulinic Acid HCl;
Delta-Aminolevulinic Acid Hydrochloride =Organic Chemical; Pharmacologic Substance ;
| - 64. 1,3-Dinitrato-2,2-bis(nitratomethyl)propane
- [The lipid soluble polyol ester of nitric acid belonging to the family of nitrovasodilators that exhibit vasodilatory property. Pentaerythritol tetranitrate releases free nitric oxide (NO) after denitration reaction, which triggers NO-dependent signaling transduction involving soluble guanylate cyclase (sGC). NO binds reversibly to the ferrous-heme center of sGC, thereby causes conformational change and activates the enzyme. Activation results in increasing cellular levels of cyclic guanosine monophosphate (cGMP) within vascular smooth muscle, which results in vasodilation mediated by cGMP-dependent protein kinases. Furthermore, this agent causes arterial and venous bed dilation in a dose-dependent manner. ( NCI )] (UMLS (NCI) C0030858) =Organic Chemical; Pharmacologic Substance ;
=propanediol;
[CV250] ANTIANGINALS =PENTAERYTHRITOL TETRANITRATE 100 MG;
|
- 15. .delta.1-Cortisone
- [synthetic anti-inflammatory glucocorticoid derived from cortisone; biologically inert and converted to prednisolone in the liver. ( CSP )] (UMLS (NCI) C0032952) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;
Pregnadienediols;
corticosteroid analog;
=PREDNISONE MISC. POWDER (GM);
PREDNISONE 1 MG/ML;
PREDNISONE 2.5 MG;
PREDNISONE 20 MG;
PREDNISONE 25 MG;
PREDNISONE 5 MG/ML;
PREDNISONE 50 MG;
PREDNISONE 1 MG;
PREDNISONE 10 MG;
prednisolone 1 MG/ML;
PREDNISONE 5 MG | - 65. 1,3-Dinitro-4-chlorobenzene
- [A skin irritant that may cause dermatitis of both primary and allergic types. Contact sensitization with DNCB has been used as a measure of cellular immunity. DNCB is also used as a reagent for the detection and determination of pyridine compounds. ( MSH )] (UMLS (NCI) C0012460) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
|
- 16. 1 DEG BURN BACK OF HAND
- [ ] (UMLS (ICD9CM) C0161218) =Injury or Poisoning
| - 66. 1,3-Diphenyl-1-triazene
- [An orange crystalline solid compound that is metabolized to benzene in vivo. Diazoaminobenzene is used as a chemical intermediate, complexing agent and polymer additive and is a contaminant in several dyes used in drugs, cosmetics and foods. Diazoaminobenzene is genotoxic in bacteria and rodents. It is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0057742) =Organic Chemical
|
- 17. 1 DEG BURN FINGR W THUMB
- [ ] (UMLS (ICD9CM) C1112529) Erythema due to burn [first degree] of two or more digits of hand including thumb =Injury or Poisoning
| - 67. 1,4 diazine
- [ ] (UMLS (CSP) C0677630) =Organic Chemical
|
- 18. 1'-Demethyl-1'-nitroso-nicotine
- [A yellow, oily liquid nitrosamine that solidifies at cold temperatures and emits toxic fumes of nitrogen oxides when heated to decomposition. Nitrosonornicotine is found in tobacco products and is likely produced by the nitrosation of nicotine during the making and smoking of tobacco products. This substance is only used in research to induce tumors in experimental animals. Exposure to nitrosonornicotine affects the liver and nitrosonornicotine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0067113) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 68. 1,4 Diethylene Ether
- [A synthetic, volatile, colorless liquid that is miscible with water, most organic solvents, aromatic hydrocarbons and oils. It is used primarily as a stabilizer in chlorinated solvents. 1,4-Dioxane is also used as a solvent for numerous commercial products and as a wetting/dispersing agent in textile processing. In research, it is used in certain biological procedures such as liquid scintillation counting and the preparation of histological sections for microscopic examination. The primary routes of potential human exposure to 1,4-dioxane are inhalation, ingestion and dermal contact. Acute exposure to low levels of 1,4-dioxane vapors causes eye and nose irritation. Exposure to very high levels of these vapors can result in liver and kidney damage and death. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044018) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
|
- 19. 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amine
- [A tricyclic nucleoside with potential antineoplastic activity. As a purine analog, triciribine phosphate inhibits the enzymes amidophosphoribosyltransferase and inosine monophosphate dehydrogenase, resulting in decreased purine nucleotide biosynthesis, decreased DNA and protein synthesis, and cell cycle arrest. This agent may also exhibit antiviral activity. (NCI04) ( NCI )] (UMLS (NCI) C0077070) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 69. 1,4-Diamino-2,3-dicyano-1,4- bis(2-aminophynyltio)butadiene
- (UMLS (NCI) C0755559) Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile =Organic Chemical; Pharmacologic Substance ;
|
- 20. 1,1'-(2,3-Dimethyl-1,4-butanediyl)bis(3,4-dimethoxybenzene)
- [A semi-synthetic nordihydroguaiaretic acid (NDGA) derivative and transcriptional inhibitor with potential antiviral and antitumor activity. Tetra-O-methyl nordihydroguaiaretic acid competes with the transcription factor Sp1 for specific Sp1 DNA binding domains within gene promoter regions during DNA synthesis. In viral-infected cells, blocking of the Sp1 binding site suppresses Sp1-regulated viral promoter activity and gene expression, thereby inhibiting viral transcription and replication. In tumor cells, blockage of Sp1 binding sites by this agent interferes with the transcription of the Sp1-dependant genes cyclin-dependant kinase (Cdc2) and survivin, both overexpressed in many cancers. By suppressing Sp1-regulated transcription, tetra-O-methyl nordihydroguaiaretic acid inhibits the production of cdc2 and survivin leading to a reduction of tumor cell proliferation and an induction of apoptosis. ( NCI )] (UMLS (NCI) C0654036) =Organic Chemical; Pharmacologic Substance ;
| - 70. 1,4-Dichlor-B
- [A synthetic, white crystalline solid that is practically insoluble in water and soluble in ether, chloroform, carbon disulfide, benzene, alcohol and acetone. It is used primarily as a space deodorant in products such as room deodorizers, urinal and toilet bowl blocks, and as an insecticide fumigant for moth control. When 1,4-dichlorobenzene is heated to decomposition, toxic gases and vapors (such as hydrochloric acid and carbon monoxide) are released. The primary route of potential human exposure to this compound is inhalation. Acute inhalation exposure to 1,4-dichlorobenzene can result in coughing and breathing difficulties. Breathing high levels of this chemical can cause headaches, dizziness and liver damage. Contact with 1,4-dichlorobenzene can irritate the eyes, leading to burning and tearing. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0048243) =Organic Chemical; Hazardous or Poisonous Substance
|
- 21. 1,1'-Dichlorodimethyl Ether
- [A colorless, flammable, carcinogenic liquid with an extremely suffocating odor. Bis(Chloromethyl) Ether is used in industry as an alkylating agent, a chemical intermediate, a monitoring indicator for the presence of chloromethyl ether, and as a laboratory reagent. This substance is irritating to eyes and mucous membranes and emits toxic vapors of hydrochloric acid and other chlorinated compounds when heated to decomposition. Exposure to Bis(Chloromethyl) ether is associated with higher risk of developing lung cancer, mainly small-cell type, and the risk increases with increasing duration and cumulative exposure. (NCI05) ( NCI )] (UMLS (NCI) C0005627) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 71. 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
- [A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms. ( NCI )] (UMLS (NCI) C0028365) =Organic Chemical; Pharmacologic Substance ;
=Quinolones;
[AM900] ANTI-INFECTIVES, OTHER =NORFLOXACIN 400 MG;
NORFLOXACIN 0.3 % |
- 22. 1,1-Dichloro-2-chloroethylene
- [toxic liquid widely used as an industrial solvent, formerly used as an inhalation anesthetic. ( CSP )] (UMLS (NCI) C0040905) =Organic Chemical; Pharmacologic Substance =[CN200] ANESTHETICS;
haloalkene | - 72. 1,4-Dimethyl-2,3-benzphenanthrene
- [polycyclic aromatic hydrocarbon that is a potent carcinogen. ( CSP )] (UMLS (NCI) C0000677) =Organic Chemical; Hazardous or Poisonous Substance
|
- 23. 1,1-Dimethylbiguanide
- [A biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin, thereby suppressing hepatic glucose production and increasing hepatic glycogen stores. In addition, metformin hydrochloride increases the number and/or affinity of insulin receptors on cell surface membranes in muscle and adipose tissue, thereby increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. ( NCI )] (UMLS (NCI) C0025598) =Organic Chemical; Pharmacologic Substance =Biguanides;
antihyperglycemic;
[HS502] HYPOGLYCEMIC AGENTS, ORAL;
=1,1-Dimethylbiguanide Hydrochloride | - 73. 1,4:3,6-Dianhydro-D-glucitol 5-nitrate
- [The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05) ( NCI )] (UMLS (NCI) C0064079) =Organic Chemical; Pharmacologic Substance ;
=ISOSORBIDE;
ISOSORBIDE DINITRATE =ISOSORBIDE MONONITRATE 120 MG;
ISOSORBIDE MONONITRATE 10 MG;
ISOSORBIDE MONONITRATE 20 MG;
ISOSORBIDE MONONITRATE 60 MG;
ISOSORBIDE MONONITRATE 30 MG |
- 24. 1,1-Dimethylbiguanide Hydrochloride
- [The hydrochloride salt form of metformin, a biguanide with antihyperglycemic activity. Metformin hydrochloride exerts its action by improving hepatic sensitivity to insulin, thereby suppressing hepatic glucose production and increasing hepatic glycogen stores. In addition, metformin hydrochloride increases the number and/or affinity of insulin receptors on cell surface membranes in muscle and adipose tissue, thereby increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. ( NCI )] (UMLS (NCI) C0770893) Metformin HCl;
Metformin Hydrochloride;
METFORMIN HYDROCHLORIDE PREPARATION;
N,N-Dimethylimidodicarbonimidic Diamide Monohydrochloride =Organic Chemical; Pharmacologic Substance =1,1-Dimethylbiguanide;
=METFORMIN HYDROCHLORIDE 1000 MG;
METFORMIN HYDROCHLORIDE 500 MG;
METFORMIN HYDROCHLORIDE 850 MG;
METFORMIN HYDROCHLORIDE 250 MG | - 74. 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one
- [drug used to treat gout and other conditions in which there is an excessive buildup of uric acid. ( CSP )] (UMLS (NCI) C0002144) =Organic Chemical; Pharmacologic Substance ;
|
- 25. 1,1-Dimethylhydrazine
- [A clear, colorless, flammable, hygroscopic liquid with a fishy smell that emits toxic fumes of nitrogen oxides when heated to decomposition, and turns yellow upon contact with air. 1,1-Dimethylhydrazine is mainly used as a high-energy fuel in jets and rockets, but is also used in chemical synthesis, in photography and to control the growth of vegetation. This substance is also found in tobacco products. Exposure to 1,1-dimethylhydrazine results in irritation of skin, eyes and mucous membranes, and can affect liver and central nervous system. 1,1-Dimethylhydrazine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0058187) =Organic Chemical
| - 75. 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one Monosodium Salt
- [The sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04) ( NCI )] (UMLS (NCI) C0278766) =Organic Chemical; Pharmacologic Substance
|
- 26. 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
- [A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C0936065) 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-;
Becatecarin;
DEAE-Rebeccamycin;
Rebeccamycin analog;
Rebeccamycin Analogue;
=Organic Chemical; Antibiotic ;
| - 76. 1,6-Dinitropyrene
- [A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 1,6-dinitropyrene emits toxic fumes of nitrogen oxides. 1,6-dinitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to this chemical is inhalation. 1,6-dinitropyrene has been detected at low concentrations in ambient air. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044050) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 27. 1,2 diazole
- [5-membered aromatic ring structure with 2 adjacent nitrogen heteroatoms. ( CSP )] (UMLS (CSP) C0072662) =Organic Chemical ;
=azole;
=antipyrine | - 77. 1,7-Dihydro-6H-purine-6-thione
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0000618) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 28. 1,2 dihydroxybenzene
- [A chemical originally isolated from a type of mimosa tree. Catechol is used as an astringent, an antiseptic, and in photography, electroplating, and making other chemicals. It can also be man-made. ( NCI )] (UMLS (NCI) C0054858) =Organic Chemical; Pharmacologic Substance
| - 78. 1,8-Dihydroxy-9(10H)-anthracenone
- [A natural anthraquinone derivative, anti-psoriatic and anti-inflammatory Anthralin (dithranol) controls skin growth by reducing DNA synthesis and mitotic activity in the hyperplastic epidermis, restoring a normal rate of cell proliferation and keratinization. Used topically in the treatment of psoriasis, dermatoses, and alopecia areata, it is also used in biomedical research due to its effect on EGFR autophosphorylation. (NCI04) ( NCI )] (UMLS (NCI) C0003166) =Organic Chemical; Pharmacologic Substance
|
- 29. 1,2,3,4-Dibenzopyrene
- [A yellowish-reddish, carcinogenic aromatic hydrocarbon consisting of six fused rings and produced by the incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in coal gasification products, cigarette smoke and fossil fuels. This substance is used only for research purposes to induce tumorigenesis. Dibenzo[a,e]pyrene is a mutagen and is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0057769) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 79. 1,8-Dinitropyrene
- [A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 1,8-dinitropyrene emits toxic fumes of nitrogen oxides. 1,8-dinitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to this chemical is inhalation. Detectable levels of 1,8-dinitropyrene have been found in respirable particulates from ambient atmospheric samples. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0044067) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 30. 1,2,4,5-Dibenzopyrene
- [A yellowish-reddish, aromatic hydrocarbon consisting of six fused rings and produced by incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in gasoline exhaust, tobacco smoke and fossil fuels. This substance is used only for research purposes. Dibenzo[a,e]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057766) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 80. 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one Monosodium Salt
- [The sodium salt form of penciclovir, a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. ( NCI )] (UMLS (NCI) C0892839) 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Monosodium Salt;
PENCICLOVIR SODIUM;
=Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance |
- 31. 1,2,5,6 dianhydrogalactitol
- [A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04) ( NCI )] (UMLS (NCI) C0011967) =Carbohydrate; Pharmacologic Substance ;
| - 81. 1-(11-Dodecylamino-10-Hydroxyundecyl)-3,7-Dimethylxanthine
- (UMLS (NCI) C0539090) =Organic Chemical; Pharmacologic Substance ;
|
- 32. 1,2,5,6-Dibenzacridine
- [A aromatic hydrocarbon consisting of five fused rings formed during the incomplete burning of organic matter. Benz[a,h]acridine is primarily found in petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. This substance is used only for research purposes. Benzo[a,h]acridine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0113624) =Organic Chemical; Hazardous or Poisonous Substance
| - 82. 1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine
- [nucleoside analog; used as an antiviral agent. ( CSP )] (UMLS (NCI) C0164662) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
Dideoxynucleosides;
dT;
1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine;
2'3' dideoxynucleoside;
=1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine;
STAVUDINE (d4T) 15 MG;
STAVUDINE (d4T) 20 MG;
STAVUDINE (d4T) 30 MG;
STAVUDINE (d4T) 5 MG/5ML;
STAVUDINE (d4T) 40 MG;
1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine |
- 33. 1,2,5,6-Dibenzanthracene
- [A crystalline, carcinogenic aromatic hydrocarbon consisting of five fused benzene rings, produced by the incomplete combustion of organic matter. Dibenzo(a,h)anthracene is primarily found in gasoline exhaust, tobacco smoke, coal tar, soot and certain food products, especially smoked and barbecued foods. This substance is used only for research purposes to induce tumorigenesis. Dibenzo(a,h)anthracene is a mutagen and is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0043769) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 83. 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane
- [psychedelic phenylisopropylamine derivative, commonly called DOM, whose mood altering effects and mechanism of action may be similar to those of LSD. ( CSP )] (UMLS (CSP) C0013007) =Organic Chemical; Pharmacologic Substance ;
=Amfetamine;
|
- 34. 1,2,6,7-Dibenzopyrene
- [A crystalline, aromatic hydrocarbon consisting of six fused rings and formed during the incomplete combustion of organic matter. Dibenzo[a,h]pyrene is primarily found in engine exhaust, cigarette tar and coal tar pitch. Dibenzo[a,h]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057767) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 84. 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)cyclohexanol
- [for the treatment of depression; a norepinephrine reuptake inhibitor ( CSP )] (UMLS (CSP) C0078569) =Organic Chemical; Pharmacologic Substance ;
=[CN600] ANTIDEPRESSANTS;
cyclohexane;
Cyclohexanols;
serotonin inhibitor;
[CN609] ANTIDEPRESSANTS, OTHER;
=Venlafaxine Hydrochloride |
- 35. 1,2,7,8-Dibenzacridine
- [A yellowish aromatic hydrocarbon consisting of five fused rings formed by the incomplete burning of organic matter. Dibenz[a,j]acridine is primarily found in gasoline exhaust, petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. This substance is used only for research purposes. Dibenz[a,j]acridine is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057761) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 85. 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
- [antineoplastic antimetabolite; has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. ( CSP )] (UMLS (NCI) C0016343) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
[AN000] ANTINEOPLASTICS;
[AM800] ANTIVIRALS;
deoxyuridine;
fluoropyrimidine;
halocarbon compound;
nucleoside analog;
=FLOXURIDINE 100 MG/ML;
|
- 36. 1,2,7,8-Dibenzopyrene
- [An aromatic hydrocarbon that consists of six fused rings and is produced by the incomplete combustion of organic matter. Dibenzo[a,i]pyrene is primarily found in gasoline exhaust, tobacco smoke and coal tar. Dibenzo[a,i]pyrene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0057768) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 86. 1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil
- [pyrimidine analog which inhibits viral DNA synthesis. ( CSP )] (UMLS (NCI) C0020811) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
=[AM800] ANTIVIRALS;
deoxyuridine;
halocarbon compound;
[OP203] ANTIVIRALS, TOPICAL OPHTHALMIC;
nucleoside analog;
|
- 37. 1,2-diammino-methy lcyclobutane-platinum (II) lactate
- [An anticancer drug that belongs to the family of drugs called platinum compounds. ( NCI )] (UMLS (NCI) C0165747) =Organic Chemical; Pharmacologic Substance
| - 87. 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine
- [A cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin dependent kinase activity in p53-mediated cell cycle arrest. (NCI) ( NCI )] (UMLS (NCI) C0148345) =Organic Chemical; Pharmacologic Substance ;
|
- 38. 1,2-Dibromo-3-chloropropane
- [A dark amber to dark brown colored, halogenated liquid with a pungent odor. Dibromochloropropane is a formerly known pesticide that was used as a soil fumigant and nematocide on crops, and is currently only used as an intermediate in organic synthesis and as a research chemical. Inhalation exposure to this substance results in central nervous system depression and pulmonary edema, while oral exposure causes gastrointestinal distress. Dibromochloropropane is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0043801) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 88. 1-(3,4-Dimethoxyphenyl)-2-propene
- [A yellowish, oily, naturally occurring liquid with a clove-like aroma and is present in many essential oils. Methyleugenol is used as a flavoring agent, as a fragrance and as an anesthetic in rodents. Methyleugenol is mutagenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in animals. (NCI05) ( NCI )] (UMLS (NCI) C0066372) =Organic Chemical; Pharmacologic Substance ;
|
- 39. 1,2-Dibromoethane
- [A clear, colorless, volatile liquid brominated hydrocarbon with a mild, sweet, chloroform-like odor that emits corrosive and toxic fumes when heated to decomposition. Ethylene dibromide is used as a chemical intermediate in the synthesis of resins, waxes, gums, dyes and pharmaceuticals and is used to produce vinyl bromide. Exposure to ethylene dibromide severely irritates the skin and causes depression and collapse. Ethylene dibromide affects DNA integrity by alkylation and is reasonably anticipated to be a human carcinogen. ( NCI )] (UMLS (NCI) C0015079) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 89. 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione
- [A sunscreen blocker. Avobenzone is a topical, broad range UV protector and blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. (NCI05) ( NCI )] (UMLS (NCI) C0097513) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =parsol 1789;
[DE300] SUN PROTECTANTS/SCREENS, TOPICAL =SUNSCREEN-15 PABA-FREE COMBINATION GEL;
SUNSCREEN 30/AVOBENZONE/PABA-FREE LOTION;
SUNSCREEN-15/AVOBENZONE/PABA-FREE LOTION;
AVOBENZONE 3 % |
- 40. 1,2-Dibromopropan-3-ol
- [A synthetic, colorless liquid that is soluble in water, alcohol, ether, benzene and acetone. It is used as an intermediate in the production of flame retardants, insecticides and pharmaceuticals. The primary routes of potential human exposure to 2,3-dibromo-1-propanol are inhalation and dermal contact. Currently, exposure of humans to this chemical is limited to workers who are exposed in an occupational setting. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0045359) =Organic Chemical
| - 90. 1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein
- [A synthetic C-terminal octapeptide identical to the sequences of the endogenous cholecystokinin hormone. Mimic action of cholecystokinin, sincalide induces gallbladder smooth muscle contraction directly, thereby reducing gallbladder size, inducing bile evacuation, and secretion of pancreatic enzymes. In addition, this agent decreases esophageal sphincter tone and delays gastric emptying via cholinergic signaling. ( NCI )] (UMLS (NCI) C0037167) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =CCK;
[DX101] NON-IONIC CONTRAST MEDIA =SINCALIDE 5 MCG;
|
- 41. 1,2-Dichloroethane
- [A clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0015081) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 91. 1-Deamino-8-D-arginine Vasopressin
- [A synthetic octapeptide, and an analogue of human hormone arginine vasopressin with antidiuretic and coagulant activities. Desmopressin binds to V2 receptors in renal collecting ducts which leads to exocytosis of von Willebrand factor (VWF) and tissue plasminogen activator (t-PA) from Weibel-Palade bodies, thereby increasing water resorption. This agent also increases nitric oxide (NO) production via activation of endothelial NO synthase, thereby induces afferent arteriolar vasodilation. Furthermore, desmopressin stimulates the release of factor VIII from endothelial cells mediated through V1a receptor, thereby promotes blood coagulation. ( NCI )] (UMLS (NCI) C0011701) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =[HS702] POSTERIOR PITUITARY;
ADH =1-(3-Mercaptopropionic acid)-8-D-arginine Vasopression Monoacetate;
DESMOPRESSIN 0.1 MG;
DESMOPRESSIN 0.2 MG |
- 42. 1,2-Dihydro-3-methyl-benz(j)aceanthrylene
- [A polycyclic aromatic hydrocarbon that consists of five fused rings with carcinogenic activity. 20-Methylcholanthrene is often used in experimental cancer studies. ( NCI )] (UMLS (NCI) C0000325) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 92. 1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt)
- [The meglumine salt form of diatrizoate, an organic, iodinated, radiopaque X-ray contrast medium used in diagnostic radiography. The iodine moiety of diatrizoate meglumine is not penetrable by X-rays, therefore blocks the X-ray film exposure by radiation. This makes it possible to distinguish on X-ray film, body parts that contain diatrizoate meglumine from body parts that do not contain this agent and allows for visualization of different body structures. ( NCI )] (UMLS (NCI) C0012005) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid;
MEGLUMINE;
Triiodobenzoic Acids;
=3,5-Diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt;
DIATRIZOATE MEGLUMINE 520 MG/ML;
DIATRIZOATE MEGLUMINE 52 %;
DIATRIZOATE MEGLUMINE 660 MG;
DIATRIZOATE MEGLUMINE 76 %;
DIATRIZOATE MEGLUMINE 34.3 %;
DIATRIZOATE MEGLUMINE 30 %;
DIATRIZOATE MEGLUMINE 85 %;
DIATRIZOATE MEGLUMINE 52.7 %;
DIATRIZOATE MEGLUMINE 18 %;
DIATRIZOATE MEGLUMINE 60 %;
DIATRIZOATE MEGLUMINE 28.5 %;
DIATRIZOATE MEGLUMINE 66 %;
DIATRIZOATE MEGLUMINE 50 % |
- 43. 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide
- [A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04) ( NCI )] (UMLS (NCI) C0244748) =Organic Chemical; Pharmacologic Substance ;
| - 93. 1-Deoxy-1-(methylamino)-D-glucitol 3-((((3-(acetylmethylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoyl)amino)acetyl)amino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodobenzoate
- [The meglumine salt form of ioxaglate, an organic iodine compound and a radiographic contrast medium. Ioxaglate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by ioxaglate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of ioxaglate meglumine. (NCI05) ( NCI )] (UMLS (NCI) C0205807) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =IOXAGLATE;
=IOXAGLATE MEGLUMINE 393 MG/ML;
|
- 44. 1,2-Dihydroxypropane
- [A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. ( MSH )] (UMLS (NCI) C0072225) =Organic Chemical; Biomedical or Dental Material =propanediol;
PROPYLENE =PROPYLENE GLYCOL STEARATE;
PROPYLENE GLYCOL DIACETATE;
CONTACT LENS CLEANING SOLN;
COAL TAR DISTILLATE;
MASSENGILL DISPOSABLE DOUCHE;
TING PWDR,TOP;
fluticasone 0.5 MG/ML Topical Cream;
KERI LOTION;
fluticasone 0.00005 MG/MG Topical Ointment;
CAFFEINE 200 MG Oral (systemic) tablet;
Urea 0.1 MG/MG Topical Ointment;
UREA 25% LOTION;
CETAPHIL CREAM;
CETAPHIL LOTION; More… | - 94. 1-Deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate
- [The meglumine salt form of iothalamate, an organic iodine compound and a radiographic contrast medium. Iothalamate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iothalamate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iothalamate meglumine. (NCI05) ( NCI )] (UMLS (NCI) C0022033) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =IOTHALAMATE;
MEGLUMINE;
Triiodobenzoic Acids;
=Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, Monosodium Salt;
IOTHALAMATE MEGLUMINE 60 %;
IOTHALAMATE MEGLUMINE 43 %;
IOTHALAMATE MEGLUMINE 17.2 %;
IOTHALAMATE MEGLUMINE 30 %;
IOTHALAMATE MEGLUMINE 52 %;
|
- 45. 1,2-Dimethylhydrazine
- [A compound used experimentally to induce tumors in animal models of carcinogenesis. In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis through deregulation of the cell cycle. This agent primarily induces gastrointestinal and vascular tumors. 1,2-Dimethylhydrazine may be found in small amounts in the environment due to its use in industry and agriculture. (NCI04) ( NCI )] (UMLS (NCI) C0043833) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 95. 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
- [An antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections, Miconazole selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes. (NCI04) ( NCI )] (UMLS (NCI) C0025942) =Organic Chemical; Pharmacologic Substance =[AM700] ANTIFUNGALS;
imidazole =1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole Mononitrate;
MICONAZOLE 10 MG/ML;
Baza Antifungal 20 MG/ML Topical Cream;
|
- 46. 1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative
- [A recombinant version of the cardiac neurohormone, human B-type natriuretic peptide (hBNP) produced by the ventricular myocardium. Nesiritide binds to natriuretic peptide receptors on vascular smooth muscle and endothelial cells, through which it triggers guanylate cyclase dependent signal transduction resulting in increase of intracellular concentrations of cGMP. This leads to smooth muscle cell relaxation causing arterial and venous dilatation. ( NCI )] (UMLS (NCI) C0054015) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =[CV900] CARDIOVASCULAR AGENTS, OTHER;
Unclassified Ingredients =NESIRITIDE RECOMBINANT | - 96. 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole Mononitrate
- [The nitrate salt form of miconazole, an antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections, Miconazole selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes. (NCI04) ( NCI )] (UMLS (NCI) C0086620) =Organic Chemical; Pharmacologic Substance ;
=1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole;
[DE102] ANTIFUNGAL, TOPICAL;
[GU300] ANTI-INFECTIVES, VAGINAL;
=Miconazole 200 MG Vaginal Suppository;
MICONAZOLE NITRATE MISC. POWDER (GM);
MICONAZOLE NITRATE 3 X 200 MG;
MICONAZOLE NITRATE 200 MG;
MICONAZOLE NITRATE 100 MG;
MICONAZOLE NITRATE 2 % |
- 47. 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane Cyclic Peptide Deriv
- [potent, long-acting synthetic somatostatin octapeptide analog. ( CSP )] (UMLS (NCI) C0028833) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =[GA400] ANTIDIARRHEAL AGENTS;
cyclic peptide;
AY 24910;
peptide hormone analog =D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide Acetate | - 97. 1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride
- [The hydrochloride salt of the partial estrogen antagonist nafoxidine. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04) ( NCI )] (UMLS (NCI) C0205850) =Organic Chemical; Pharmacologic Substance
|
- 48. 1,2-Dithioglycerol
- [A metal chelating agent that is used as an antidote in arsenic, gold, lead, mercury and other heavy metal poisoning. Metals form ligands in the body with the sulfhydryl groups of the pyruvate-oxidase enzyme system. This leads to an inhibition of the normal functioning of these enzymes that are dependent on free sulfhydryl groups for their activity. Dimercaprol reverses the enzyme inhibition by chelating the metal and regenerates free sulfhydryl groups, thereby preventing and reversing the metals toxic effects. ( NCI )] (UMLS (NCI) C0012383) =Organic Chemical; Pharmacologic Substance ;
=mercaptan;
[AD300] HEAVY METAL ANTAGONISTS =DIMERCAPROL 100 MG/ML | - 98. 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile Monohydrobromide
- [The orally bioavailable hydrobromide salt of the racemic bicyclic phthalene derivative citalopram with antidepressant activity. As a selective serotonin reuptake inhibitor (SSRI), citalopram selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system (CNS). This agent has minimal effects on the CNS neuronal reuptake of norepinephrine (NE) and dopamine (DA). ( NCI )] (UMLS (NCI) C0724555) Citalopram Hydrobromide;
CITALOPRAM HYDROBROMIDE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=citalopram;
=CITALOPRAM HYDROBROMIDE 20 MG;
CITALOPRAM HYDROBROMIDE 40 MG;
CITALOPRAM HYDROBROMIDE 10 MG/5ML |
- 49. 1,2-Dithiole-3-thione
- (UMLS (NCI) C0043854) =Organic Chemical; Pharmacologic Substance ;
| - 99. 10 day report
- (UMLS (HL7) C1546917) =Temporal Concept =Report timing;
|
- 50. 1,25-Dihydroxy-16-ene-23-yne-Vitamin D3
- (UMLS (NCI) C0526577) =Steroid; Pharmacologic Substance
| - 100. 10 days
- (UMLS (HL7) C1547061) =Temporal Concept =Time delay post challenge;
|
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