DNA Replication Licensing Factor MCM6
[Widely expressed by E2F-regulated human MCM6 Gene (MCM Family), 821-aa 93-kDa DNA Replication Licensing Factor MCM6 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complex during G1, detaches from it during S phase, and prevents over-replication. Repressed in quiescent cells, MCM6 is rapidly induced at G1/S by growth factor stimulation; protein level peaks at G1/S. A stable MCM2/4/6/7 complex exhibits DNA unwinding ATPase/DNA helicase activity involved in replication initiation. MCM2/4/6/7 phosphorylation by CDC2 kinase reduces helicase activity. Hexameric MCM2-7 complex is a key element of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. (NCI) ( NCI )]
UMLS (NCI) C1333240MCM6
Minichromosome Maintenance Protein 6
MIS5
P105MCM
Minichromosome Maintenance Protein 6
MIS5
P105MCM
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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