DNA-Activated Protein Kinase Catalytic Subunit
[Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), encoded by the PRKDC gene, is a nuclear protein serine/threonine kinase of a multiprotein complex DNA-dependent protein kinase (DNA-PK). Two protein isoforms are produced by alternative splicing and binds DNA for catalysis. PRKDC relies on the heterodimer Ku70/Ku80 autoantigen, the DNA-binding DNA-PK component, to direct it to DNA double-stranded breaks for other discontinuities in the DNA double helix and trigger its kinase activity. PRKDC is critical for repair of DNA double strand breaks via the nonhomologous DNA end joining, telomere maintenance via telomere capping, innate immune response via V(D)J recombination (where V is variable, D is diversity, and J is joining) as well as transcriptional regulation via p53, the site-specific recombination process in developing B and T lymphocytes to generate the variable regions of immunoglobulin and T cell receptor genes. ( NCI )]
UMLS (NCI) C0212694- Amino Acid, Peptide, or Protein
- Enzyme
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