- 1. (+)-2-Ethoxy-alpha-(((S)-alpha-isobutyl-o-piperidinobenzyl)carbamoyl)-p-toluic Acid
- [A benzoic acid derivative belonging to the meglitinide class of antidiabetic agents. Repaglinide blocks ATP-dependent potassium channels in pancreatic beta cells, thereby causing depolarization of the cell membrane and subsequent opening of calcium channels. The increased calcium influx into the pancreatic beta cells induces insulin secretion, thereby lowering blood glucose levels. ( NCI )] (UMLS (NCI) C0246689) =Organic Chemical; Pharmacologic Substance ;
=carbamate;
Piperidines;
[HS502] HYPOGLYCEMIC AGENTS, ORAL;
=REPAGLINIDE 1 MG;
REPAGLINIDE 2 MG;
REPAGLINIDE 0.5 MG | - 51. 10-EdAM
- [An anticancer drug that belongs to a family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0044667) =Organic Chemical; Pharmacologic Substance ;
|
- 2. (+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride
- [The hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. ( NCI )] (UMLS (NCI) C0770927) Lomefloxacin Hydrochloride;
LOMEFLOXACIN HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=Lomefloxacin;
=LOMEFLOXACIN HYDROCHLORIDE 400 MG;
| - 52. 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol
- [A synthetic progestogen with progesterone hormone receptor agonistic activity. Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. This leads to an inhibition of LH release and prevents ovulation and alters the cervical mucus. Desogestrel is used in birth control pills alone or in combination with estrogens. ( NCI )] (UMLS (NCI) C0057558) =Steroid; Pharmacologic Substance; Hormone =Norpregnenes;
[HS200] CONTRACEPTIVES, SYSTEMIC =DESOGESTREL 0.15 MG;
DESOGESTREL 0.1-0.15 MG;
DESOGESTREL 0.15-0.2 MG |
- 3. (+-)-4'-(4-(Ethylheptylamino)-1-hydroxybutyl)methanesulfonanilide Fumarate(2:1)(salt)
- [The fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval. (NCI05) ( NCI )] (UMLS (NCI) C0123053) =Organic Chemical; Pharmacologic Substance =ibutilide;
=IBUTILIDE FUMARATE 0.1 MG/ML;
| - 53. 15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,1
- [A 33-epi-chloro-derivative of the ascomycin macrolactam with immunosuppressant property. Pimecrolimus binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin. Via dephosphorylation, calcineurin is the enzyme responsible for activating nuclear factor of activated T-cells (NF-AT), a T cell transcriptional regulatory factor. As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. However, pimecrolimus mode of action is cell-selective and does not affect Langerhans' cells/dendritic cells and primary fibroblasts. ( NCI )] (UMLS (NCI) C1099414) 33-epi-Chloro-33-desoxyascomycin;
PIMECROLIMUS;
PIMECROLIMUS UNIDENTIFIED;
PIMECROLIMUS PREPARATION;
PIMECROLIMUS UNIDENTIFIED =Organic Chemical; Pharmacologic Substance =[DE900] DERMATOLOGICALS, TOPICAL OTHER;
Unclassified Ingredients =PIMECROLIMUS 1 % |
- 4. (+/-)-13-Ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one
- [A synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes. This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (NCI04) ( NCI )] (UMLS (NCI) C0028368) =Steroid; Pharmacologic Substance; Hormone =Norpregnenes;
[HS200] CONTRACEPTIVES, SYSTEMIC =(17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one;
Norgestimate;
NORGESTREL 0.5 MG;
NORGESTREL 0.3 MG;
NORGESTREL 75 MCG;
| - 54. 2,3-Epoxy-1-propanol
- [Slightly viscous, colorless and odorless liquid cyclic ether. Glycidol is used as a stabilizer for natural oils and vinyl polymers, as an alkylating agent, a sterilant, a demulsifier, a dye-leveling agent and it is also used as an intermediate in the synthesis of glycerol, glycidyl ethers and amines. Exposure to Glycidol irritates the skin, eyes, and mucous membranes and depresses the central nervous system in humans. Glycidol induces mutations in human lymphocytes and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0061587) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid ;
|
- 5. (-)-Ephedrine
- [alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine; has been used in the treatment of several disorders including asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. ( CSP )] (UMLS (NCI) C0014479) =Organic Chemical; Pharmacologic Substance ;
=adrenergic agent;
bronchodilator;
Phenethylamines;
Propanolamines;
[AU100] SYMPATHOMIMETICS (ADRENERGICS);
[RE103] BRONCHODILATORS, SYMPATHOMIMETIC,ORAL =PSEUDOEPHEDRINE;
cinnamedrine;
EPHEDRINE HYDROCHLORIDE;
EPHEDRINE SULFATE;
EPHEDRINE TANNATE;
EPHEDRINE HYDROCHLORIDE;
EPHEDRINE SULFATE;
EPHEDRINE TANNATE;
| - 55. 2-(3-ethylureido)-6-methylpyridine
- (UMLS (NCI) C0532706) =Organic Chemical; Pharmacologic Substance
|
- 6. (-)-Epigallocatechin 3-gallate
- [A phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is under study as a potential cancer chemopreventive agent. (NCI) ( NCI )] (UMLS (NCI) C0059438) =Organic Chemical; Pharmacologic Substance ;
| - 56. 2-Ethyl-4-pyridinecarbothioamide
- [A nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unknown, it may inhibit the synthesis of mycolic acid, a saturated fatty acid found in the bacterial cell wall, thereby inhibiting bacterial cell wall synthesis. This eventually leads to bacterial cell wall disruption and cell lysis. Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug at the site of infection and the susceptibility of the organism involved. ( NCI )] (UMLS (NCI) C0015021) =Organic Chemical; Pharmacologic Substance ;
=Isonicotinic Acids;
[AM500] ANTITUBERCULARS =ETHIONAMIDE 250 MG |
- 7. (-)-Epothilone B
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called epothilones. Also called EPO906. ( NCI )] (UMLS (NCI) C0297960) =Organic Chemical; Pharmacologic Substance
| - 57. 3' 5' exonuclease
- [Three Prime-Five Prime Exonucleases prefer mismatched 3-prime termini, catalyze nucleoside monophosphate excision from 3-prime DNA termini and may be a DNA polymerase III subunit, which does not have intrinsic exonuclease activity. 3-prime terminal nucleotide excision from DNA is required to generate termini for subsequent DNA metabolic pathways. ( NCI )] (UMLS (CSP) C0950448) 3'-5' Exonuclease;
=Amino Acid, Peptide, or Protein; Enzyme |
- 8. (2E)-5-[3-[(Phenylsufonyl) Aminol Phenyl]-pent-2-en-4-ynohydroxamic Acid
- [An inhibitor of histone deacetylase. It is an aromatic sulfonamide hydroxamate initially found in a screen for inhibitors of the tumorigenic phenotype of K-ras-transformed NIH3T3 cells. ( NCI )] (UMLS (NCI) C0391491) =Organic Chemical; Pharmacologic Substance ;
| - 58. 3' exonuclease
- [ ] (UMLS (CSP) C0075028) =Amino Acid, Peptide, or Protein; Enzyme ;
=exonuclease;
|
- 9. (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid, Ethyl Ester
- [A synthetic oral retinoid that is a prodrug of acitretin. Etretinate activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. Etretinate is no longer commercially available in the U.S. due to the extended potential for teratogenic effects related to its long half-life. (NCI04) ( NCI )] (UMLS (NCI) C0015137) =Organic Chemical; Pharmacologic Substance ;
=Retinoic Acid Agent;
[DE801] ANTIPSORIATICS, SYSTEMIC =ETRETINATE 10 MG;
ETRETINATE 25 MG;
| - 59. 3-Ethyl-3-methylpyrrolidine-2,5-dione
- [A succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures. ( NCI )] (UMLS (NCI) C0015043) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
succinimide =ETHOSUXIMIDE 250 MG;
ETHOSUXIMIDE 250 MG/5ML;
|
- 10. (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
- [A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals. (NCI04) ( NCI )] (UMLS (NCI) C0077063) =Organic Chemical; Antibiotic ;
| - 60. 3-ethyl-5-phenyl-2,4-imidazolidinedione
- [A hydantoin anticonvulsant with anti-epileptic activity. The mechanism of action is not completely known, but is thought to be fairly similar to phenytoin. Ethotoin influences synaptic transmission by altering sodium and calcium ion influx across neuronal membranes in the repolarization, depolarization, and membrane stability phase and interferes with the calcium uptake in presynaptic terminals. This inhibits neuronal firing and results in the stabilization of neuronal membranes, thereby preventing the spread of seizure activity at the motor cortex. ( NCI )] (UMLS (NCI) C0015046) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
hydantoin =ETHOTOIN 250 MG;
ETHOTOIN 500 MG;
|
- 11. (9E)-Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime]
- [Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections. ( MSH )] (UMLS (NCI) C0035891) =Organic Chemical; Antibiotic ;
| - 61. 4, 8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H, 6H)tetrone, octahydro-
- [A bisdioxopiperazines analog with antineoplastic activity. Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis. This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors. (NCI04) ( NCI )] (UMLS (NCI) C0066593) =Organic Chemical; Pharmacologic Substance ;
|
- 12. (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid
- [specific isomer of hexahydro-5-hydroxy-4- (3-hydroxy-4-methyl-1- octen-6-ynyl) pentalenevaleric acid; prostacyclin analog and agonist; has vasodilator and anticoagulant actions and therefore may be useful for treating a variety of vascular disorders. ( CSP )] (UMLS (NCI) C0079594) =Eicosanoid; Pharmacologic Substance =prostaglandin analog;
| - 62. 4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one
- [A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. ( NCI )] (UMLS (NCI) C0030049) =Organic Chemical; Pharmacologic Substance =[CN101] OPIOID ANALGESICS;
codeine =4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride;
Oxycodone Terephthalate;
4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride;
Oxycodone Terephthalate;
OXYCODONE 5 MG;
|
- 13. (E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene
- [A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM). Droloxifene competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. (NCI) ( NCI )] (UMLS (NCI) C0047498) =Organic Chemical; Pharmacologic Substance ;
| - 63. 5' 3' exonuclease
- [Five Prime-Three Prime Exonucleases specifically catalyze the hydrolysis of terminal phosphodiester bonds of nucleic acids. Human XRN1 and XRN2 are similar to mouse Dhm1 and yeast dhp1, involved in homologous recombination, meiosis, telomere maintenance, RNA synthesis and RNA trafficking. XRN1 localizes to cytoplasmic complexes of mRNA-degrading enzymes and prefers RNA over DNA substrates. XRN2 promotes transcription termination by 5-prime to 3-prime exonuclease activity and autocatalytic cotranscriptional cleavage that may induce dissociation of RNA polymerase II from the DNA template, but function has not yet been fully determined. ( NCI )] (UMLS (CSP) C0094209) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 14. (E)-2-Butenedioic Acid
- (UMLS (NCI) C0060825) =Organic Chemical; Pharmacologic Substance ;
=fumarate;
Inactive Ingredient Preparations =AL OH 400MG/MG OH 400MG/SIMETHICONE 30MG TAB,CHEWABLE;
| - 64. 5' exonuclease
- [A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis. ( MSH )] (UMLS (CSP) C0070828) =Amino Acid, Peptide, or Protein; Enzyme =PDE;
|
- 15. (E)-2-Butenedioic Acid, Dimethyl Ester
- (UMLS (NCI) C0058218) =Organic Chemical; Pharmacologic Substance ;
| - 65. 5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione
- [barbituric acid derivative that acts as a nonselective central nervous system depressant. ( CSP )] (UMLS (NCI) C0031412) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
barbiturate;
[CN300] SEDATIVES/HYPNOTICS;
[CN301] BARBITURIC ACID DERIVATIVE, SEDATIVES/HYPNOTICS =2-Deoxyphenobarbital;
PHENOBARBITAL SODIUM;
PHENOBARBITAL 100 MG;
PHENOBARBITAL 15 MG;
PHENOBARBITAL 15 MG/ML;
PHENOBARBITAL 16 MG;
PHENOBARBITAL 16.2 MG;
PHENOBARBITAL 15 MG/5ML;
PHENOBARBITAL 16.2 MG/5ML;
PHENOBARBITAL 18.5 MG/5ML;
PHENOBARBITAL 30 MG;
PHENOBARBITAL 20 MG/5ML;
PHENOBARBITAL 50 MG;
PHENOBARBITAL 65 MG;
PHENOBARBITAL 8 MG;
PHENOBARBITAL 90 MG;
PHENOBARBITAL 32 MG;
PHENOBARBITAL 45 MG;
PHENOBARBITAL 60 MG;
PHENOBARBITAL 97.2 MG;
PHENOBARBITAL 20 MG;
PHENOBARBITAL 7.5 MG;
PHENOBARBITAL 48.6 MG;
PHENOBARBITAL 40 MG;
PHENOBARBITAL 160 MG;
PHENOBARBITAL 200 MG;
Phenobarbital 0.4 MG/ML;
PHENOBARBITAL 21.6 MG/5ML;
PHENOBARBITAL 8.1 MG |
- 16. (E)-2-Butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic Acid, Monomethanesulfonate
- [The mesylate salt form of eprosartan, a non-biphenyl, non-tetrazole, nonpeptide angiotensin II antagonist with antihypertensive activity. Eprosartan mesylate antagonizes angiotensin II type I receptors in tissues such as vascular smooth muscle and the adrenal gland. This prevents angiotensin II-induced vasoconstriction and prevents angiotensin II-mediated stimulation of aldosterone secretion by the adrenal cortex, which decreases the excretion of sodium and water and increases the excretion of potassium. ( NCI )] (UMLS (NCI) C0772203) 2-Thiophenepropanoic Acid, alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1H-imidazol-5-yl)methylene)-,(E)-, Monomethanesulfonate;
Eprosartan Mesylate;
EPROSARTAN MESYLATE PREPARATION =Organic Chemical; Pharmacologic Substance =Eprosartan;
=EPROSARTAN MESYLATE 400 MG;
EPROSARTAN MESYLATE 600 MG | - 66. 5-Ethynyl-2,4(1H,3H)-pyrimidinedione
- [An anticancer drug that increases the effectiveness of fluorouracil. Also called eniluracil. ( NCI )] (UMLS (NCI) C0098361) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 17. (E)-3,7-Dimethyl-2,6-octadien-1-ol
- (UMLS (NCI) C0061223) =Organic Chemical; Pharmacologic Substance ;
| - 67. 6,7-Epoxytropine Tropate
- [A toluidine derivative and intermediate-acting amino amide with local anesthetic property. Prilocaine stabilizes the neuronal membrane by preferential binding to and inhibiting depolarization of the voltage-gated sodium channel. This results in a decrease in membrane permeability and subsequent inhibition of the ionic sodium influx required for the initiation and conduction of impulses. ( NCI )] (UMLS (NCI) C0033124) =Organic Chemical; Pharmacologic Substance =Anilides;
[CN204] LOCAL ANESTHETICS, INJECTION =2-(Propylamino)-o-propionotoluidide Hydrochloride;
PRILOCAINE 2.5 % |
- 18. (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
- [synthetic nonsteroidal estrogen used in the treatment of menopausal, postmenopausal, and other disorders sensitive to estrogens; an epigenetic carcinogen. ( CSP )] (UMLS (NCI) C0012203) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =female antifertility drug;
[HS300] ESTROGENS;
estrogen analog;
stilbene;
Teratogen;
=(E)-4,4'-(1,2-ethenediyl)-bisphenol bis(dihydrogen phosphate);
DIETHYLSTILBESTROL 1 MG;
DIETHYLSTILBESTROL 5 MG;
| - 68. 6-Ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline
- [Antioxidant; also a post-harvest dip to prevent scald on apples and pears. ( MSH )] (UMLS (NCI) C0015051) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
|
- 19. (E)-4,4'-(1,2-ethenediyl)-bisphenol bis(dihydrogen phosphate)
- [A synthetic nonsteroidal estrogen that competes with androgen receptors and prevents further growth of androgen dependent tumor cells. (NCI) ( NCI )] (UMLS (NCI) C0060692) =Organic Chemical; Pharmacologic Substance; Hormone =(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol;
TO BE DELETED INGREDIENT PREPARATIONS =DIETHYLSTILBESTROL DIPHOSPHATE 50 MG/ML;
DIETHYLSTILBESTROL DIPHOSPHATE 50 MG | - 69. 7-Ethyl-10-Hydroxycamptothecin
- (UMLS (NCI) C0099808) =Organic Chemical; Pharmacologic Substance ;
|
- 20. (E)-4-[2-[4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholine
- (UMLS (NCI) C0247161) =Organic Chemical; Pharmacologic Substance ;
| - 70. 70% Ethanol
- [An aqueous dilution of ethanol containing 70% ethanol by volume. Used as a disinfecting agent and as a fixative. ( NCI )] (UMLS (NCI) C1381542) 70% Ethyl Alcohol;
Alcohol, Ethyl 70%;
ALCOHOL,ETHYL 70 %;
Ethyl Alcohol, 70% =Clinical Drug =Absolute ethanol;
=ALCOHOL, ETHYL 70% Topical liquid |
- 21. (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
- [A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. (NCI05) ( NCI )] (UMLS (NCI) C0073096) =Organic Chemical; Pharmacologic Substance ;
| - 71. 7E11-C5.3-GYK-DTPA
- [An immunoconjugate of the murine monoclonal antibody, 7E11-C5.3 (Capromab), conjugated to the linker-chelator, glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl). Capromab, an IgG1 kappa immunoglobulin, binds specifically to a cytoplasmic epitope of prostate-specific membrane glycoprotein (PSMA) that is only expressed by prostatic epithelial cells (benign and malignant). Capromab pendetide can be used in diagnostic or detection of prostate cancer when labeled with Indium I-111, which emits gamma radiation and X-Ray photons that can be captured by gamma camera allowing imaging of PMSA expressing tissues. ( NCI )] (UMLS (NCI) C0529572) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
|
- 22. (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic Acid
- [A synthetic alkylamine with non-sedative antihistaminergic activity. Acrivastine competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial, and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. (NCI05) ( NCI )] (UMLS (NCI) C0054340) =Organic Chemical; Pharmacologic Substance ;
=TRIPROLIDINE;
[AH400] ANTIHISTAMINES, ALKYLAMINE =ACRIVASTINE 8 MG | - 72. 9-Ethyl 6-Mercaptopurine
- [A synthetic alkyl derivative prodrug of the antineoplastic agent 6-mercaptopurine (6-MP). In vivo, 9-ethyl 6-mercaptopurine appears to be converted to 6-MP, which substitutes for the normal nucleoside and fraudulently incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. (NCI04) ( NCI )] (UMLS (NCI) C0626019) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 23. (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene Methanamine
- [A synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important component of fungal cell membranes. As a result, this agent disrupts fungal cell membrane synthesis and inhibits fungal growth. ( NCI )] (UMLS (NCI) C0076110) =Organic Chemical; Pharmacologic Substance =[AM700] ANTIFUNGALS;
naphthalene;
[DE102] ANTIFUNGAL, TOPICAL;
=(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine Hydrochloride | - 73. E
- [Maxillary right central primary incisor ( HL7V3.0 )] (UMLS (HL7) C0227085) =Body Part, Organ, or Organ Component =Primary dentition;
|
- 24. (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine Hydrochloride
- [A synthetic allylamine derivative structurally related to naftifine, antifungal Terbinafine Hydrochloride blocks ergosterol biosynthesis by inhibition of squalene epoxidase, part of the sterol synthesis pathway for the fungal cell membrane. Highly lipophilic, it tends to accumulate in skin, nails, and fatty tissues. Terbinafine is active against dermatophytes. (NCI04) ( NCI )] (UMLS (NCI) C0771029) Terbinafine Hydrochloride;
TERBINAFINE HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene Methanamine;
=TERBINAFINE HYDROCHLORIDE 1 %;
TERBINAFINE HYDROCHLORIDE 250 MG | - 74. E Coli Infection
- [infections with bacteria of the species Escherichia coli. ( CSP )] (UMLS (NCI) C0014836) =Disease or Syndrome ;
=Enterobacteriaceae disease;
=Meningitis, Escherichia coli;
|
- 25. (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine-hydrochloride
- [The hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved. ( NCI )] (UMLS (NCI) C0304594) =Organic Chemical; Pharmacologic Substance =naftifin;
=NAFTIFINE HYDROCHLORIDE 1 % | - 75. E COLI SEPTICEMIA
- (UMLS (ICD9CM) C0276088) =Disease or Syndrome
|
- 26. (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
- [N-(4-hydroxy-3-methoxyphenylmethyl) -8-methyl-6-nonenamide; chili pepper extract and neuropeptide releasing agent selective for primary sensory peripheral neurons, used to experimentally manipulate substance P and other tachykinins, and as an analgesic for Herpes zoster infection. ( CSP )] (UMLS (NCI) C0006931) =Lipid; Pharmacologic Substance =Fatty Acids, Monounsaturated;
Solanaceous Alkaloids;
neuropharmacologic agent;
phenylamide;
[DE650] ANALGESICS, TOPICAL;
=CAPSAICIN 0.075 %;
CAPSAICIN 0.025 %;
CAPSAICIN 0.75 %;
CAPSAICIN 0.25 %;
| - 76. E O9
- (UMLS (NCI) C0059403) =Organic Chemical; Pharmacologic Substance ;
|
- 27. (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
- [A yellow pigment of the spice turmeric that is being studied in cancer prevention. ( NCI )] (UMLS (NCI) C0010467) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
| - 77. E protein
- [ ] (UMLS (CSP) C0599561) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 28. (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
- [A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) ( MSH )] (UMLS (NCI) C0015637) =Lipid; Pharmacologic Substance
| - 78. E wave
- [ ] (UMLS (CSP) C0598030) =Finding ;
|
- 29. *Entitic
- (UMLS (HL7) C1304535) =Quantitative Concept =Kind of quantity;
| - 79. E-code as reason for visit
- (UMLS (HL7) C1547488) =Intellectual Product =OCE Edit Code;
|
- 30. *Entitic Catalytic Activity
- (UMLS (HL7) C1264686) =Quantitative Concept =Kind of quantity;
| - 80. E-F1
- [Heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits) is responsible for delivery of aminoacyl tRNAs to the ribosome. Containing domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs, the alpha EF-1 subunit interacts with beta/delta subunits and mediates delivery and GTP-dependent binding of aminoacyl-tRNAs to the 80S ribosome A-site. Homologous beta and delta subunits (guanine nucleotide exchange factors) stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. The conserved gamma subunit contains an EEF1G domain and an N-terminal GST domain that may be involved in regulating EF-1 multisubunit assembly and anchorage to other cellular components. (NCI) ( NCI )] (UMLS (NCI) C0059036) =Amino Acid, Peptide, or Protein; Enzyme
|
- 31. *Entitic Number
- (UMLS (HL7) C1264689) =Quantitative Concept =Kind of quantity;
| - 81. E-mail
- (UMLS (HL7) C1547562) =Idea or Concept =Authorization Mode;
|
- 32. *Entitic Substance of Amount
- (UMLS (HL7) C1264685) =Quantitative Concept =Kind of quantity;
| - 82. E-Mail Address (for backward compatibility)
- (UMLS (HL7) C1549618) =Idea or Concept =Preferred method of contact;
|
- 33. *Entitic Volume
- (UMLS (HL7) C1264690) =Quantitative Concept =Kind of quantity;
| - 83. E-stopped
- (UMLS (HL7) C1550005) =Idea or Concept =Equipment state;
|
- 34. 1 EXTRAOC MUSCL ADVANCE
- [ ] (UMLS (ICD9CM) C0176283) =Therapeutic or Preventive Procedure
| - 84. E. coli
- [species of gram negative, facultatively anaerobic, rod shaped bacteria commonly found in the lower part of the intestine of warm blooded animals; usually nonpathogenic, but some strains are known to produce diarrhea and pyogenic infections. ( CSP )] (UMLS (NCI) C0014834) =Bacterium ;
=Escherichia;
[GA900] GASTRIC MEDICATIONS, OTHER;
Unclassified Ingredients;
Inactive Ingredient Preparations;
TO BE DELETED INGREDIENT PREPARATIONS;
=Escherichia coli k12;
Escherichia coli 0157:H7;
E.COLI 10000000 UNT/ML;
ESCHERICHIA COLI 10000000 UNT |
- 35. 1 EXTRAOC MUSCL RESECT
- [ ] (UMLS (ICD9CM) C0197958) =Therapeutic or Preventive Procedure
| - 85. E. COLI INFECT NOS
- (UMLS (ICD9CM) C0014835) =Disease or Syndrome ;
|
- 36. 1 EYE-SEV/OTH-BLIND NOS
- [ ] (UMLS (ICD9CM) C0392562) =Disease or Syndrome ;
| - 86. E0167
- [A menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signalling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. This agent inhibits tumor cell growth by inducing apoptosis and cell cycle arrest. ( NCI )] (UMLS (NCI) C0065936) =Organic Chemical; Pharmacologic Substance; Vitamin
|
- 37. 1,2-Epoxyethane
- [Colorless, odorless, flammable, toxic gaseous cyclic ether with a sweet ether-like smell. Ethylene oxide is used especially in the synthesis of ethylene glycol and as a sterilizing agent for medical supplies and foods, as a fumigant and as an insecticide. Exposure to this substance is highly irritating to the eyes, skin and respiratory tract, induces nausea and vomiting and causes central nervous system depression. Ethylene oxide is mutagenic in humans and chronic exposure is associated with an increased risk of leukemia, stomach cancer, pancreatic cancer and non-Hodgkin's lymphoma. (NCI05) ( NCI )] (UMLS (NCI) C0015087) =Organic Chemical; Hazardous or Poisonous Substance ;
=epoxide;
| - 87. E1A Binding Protein p300 Gene
- [This gene plays a role in DNA repair and regulation of transcription. ( NCI )] (UMLS (NCI) C1333336) EP300;
EP300 Gene;
=Gene or Genome ;
|
- 38. 1,2-Epoxyethylbenzene
- [A synthetic, colorless liquid that is very soluble in water. Styrene oxide is used as a chemical intermediate in the production of styrene glycol and its derivatives, cosmetics, surface coatings and other chemicals (agricultural and biological). It is also used as a reactive diluent for epoxy resins and in cross-linked polyesters and polyurethanes. Humans in the general population may be exposed to styrene oxide by contact with contaminated air or water. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0075351) =Organic Chemical
| - 88. E1A Enhancer-Binding Protein E1AF
- [Member of the ets DNA binding protein family; may bind the adenovirus E1A enhancer. (LocusLink) ( NCI )] (UMLS (NCI) C1333479) Ets Variant Protein 4;
ETV4;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 39. 1,2-Epoxypropane
- [A synthetic, highly-flammable, volatile, colorless liquid that is soluble in water and miscible with many organic solvents. Propylene oxide is used primarily as a chemical intermediate in the production of polyethers and propylene glycol. It is also used as a pesticide and a fumigant for the sterilization of packaged foods and plastic medical instruments. Acute inhalation exposure to vapors of this compound can result in respiratory tract irritation, coughing, difficulty in breathing (dyspnea) and buildup of fluid in the lungs (pulmonary edema) that can possibly lead to pneumonia. Inhale high concentrations of the vapors for short time periods may cause headache, motor weakness, incoordination, ataxia and coma. Contact with propylene oxide can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0072229) =Organic Chemical
| - 89. E1A Lipid Complex
- [E1A gene combined with lipids that serve as a means to deliver the E1A gene into the cancer cells. The combination of lipids and the E1A gene is called the E1A Lipid Complex. ( NCI )] (UMLS (NCI) C0393024) =Lipid; Pharmacologic Substance ;
|
- 40. 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, Monohydrochloride
- [The hydrochloride salt form of tripelennamine, an ethylenediamine derivative with an antihistaminergic property. Tripelennamine hydrochloride competitively blocks central and peripheral histamine H1 receptors, thereby limiting histamine's effects, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic activity. ( NCI )] (UMLS (NCI) C0304297) =Organic Chemical; Pharmacologic Substance ;
=TRIPELENNAMINE;
=TRIPELENNAMINE HYDROCHLORIDE 100 MG;
TRIPELENNAMINE HYDROCHLORIDE 2 %;
TRIPELENNAMINE HYDROCHLORIDE 0.5 % | - 90. E2(17)KB 2
- [Encoded by human UBE2D2 Gene (E2 Ubiquitin-Conjugating Enzyme Family), 147-aa 16.7-kDa Ubiquitin-Conjugating Enzyme E2D 2 targets selective degradation of short-lived and abnormal proteins, such as E6/E6-AP-induced p53 ubiquitination, through covalent attachment of ubiquitin, the second step of ubiquitin conjugation. UBE2D2 interacts with the SCF/E3 ubiquitin ligase complex. Ubiquitination involves E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. (NCI) ( NCI )] (UMLS (NCI) C1307637) UBC4/5;
UBE2D2;
Ubiquitin Carrier Protein;
Ubiquitin-Conjugating Enzyme E2-17 kDa 2;
Ubiquitin-Conjugating Enzyme E2D 2;
Ubiquitin-Protein Ligase =Amino Acid, Peptide, or Protein; Enzyme |
- 41. 1,3,5(10)-Estratrien-2,3-diol-17-one
- (UMLS (NCI) C0046200) =Steroid; Pharmacologic Substance ;
| - 91. E26 Transformation Specific Oncogene
- [Oncogene ETS was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of E26, an avian leukosis virus. ETS1 encodes 42-52 kD nuclear phosphoprotein transcription factors that interact with purine-rich promoter/enhancer sequences in the TCRA gene. ETS1 also regulates p16(INK4A) gene expression. The human gene is located at 11q23.3. ( NCI )] (UMLS (NCI) C0812380) ETS;
Oncogene ETS =Gene or Genome ;
|
- 42. 1,3,5(10)-Estratrien-3-ol-17-one
- [aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen; converted from androstenedione directly, or from testosterone via estradiol; in humans, it is produced primarily by the cyclic ovaries, placenta, and the adipose tissue of men and postmenopausal women. ( CSP )] (UMLS (NCI) C0014942) =Steroid; Pharmacologic Substance; Hormone =17-Ketosteroids;
Estrenes;
[HS300] ESTROGENS;
=Estrone Hydrogen Sulfate compound with Piperazine(1:1);
Estrone Sodium Sulfate;
ESTRONE 1.5 MG;
ESTRONE 1.5 MG/ML;
ESTRONE 2 MG/ML;
ESTRONE 2.5 MG;
ESTRONE 5 MG/ML;
ESTRONE 2 MG | - 92. E2A
- [Encoded by human TCF3 Gene, E12 and E47 alternative isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3 are homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI) ( NCI )] (UMLS (NCI) C1336780) E2A Immunoglobulin Enhancer Binding Factor E12;
E2A Immunoglobulin Enhancer Binding Factor E47;
Immunoglobulin Transcription Factor 1;
ITF1;
Kappa-E2-Binding Factor;
TCF3;
Transcription Factor 3;
Transcription Factor E2-Alpha =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 43. 1,3-Ethylene-2-thiourea
- [A greenish, crystalline compound with a faint amine smell and emits toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition. Ethylene thiourea is mainly used as an accelerator in the production of rubber, and in the manufacture of ethylene bisdithiocarbamate pesticides. This substance is teratogenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0015097) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 93. E2F Transcription Factor 1
- [Transcription factor E2F1 binds to DNA as homo or heterodimers with DP1 or DP2. It activates p53 and p73 gene expression. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner by accumulation of p73 or by a death receptor-dependent mechanism via down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB/E2F repression mediates G1 arrest triggered by TGFB, by p16(INK4A), and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. (from OMIM and NCI) ( NCI )] (UMLS (NCI) C1506928) E2F1;
E2F-1;
PBR3;
PRB-Binding Protein E2F-1;
RBAP-1;
RBBP-3;
Retinoblastoma Associated Protein 1;
Retinoblastoma Binding Protein 3;
Retinoblastoma-Associated Protein 1;
Transcription Factor E2F =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 44. 1,4-Epoxy-1,3-butadiene
- [compounds with a 5-membered ring of four carbons and an oxygen; aromatic heterocycles; the reduced form is tetrahydrofuran. ( CSP )] (UMLS (NCI) C0060850) =Organic Chemical =oxygenous heterocyclic compound;
=benzofuran;
N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine | - 94. E2F Transcription Factor 1 Gene
- [This gene plays a regulatory role in G1/S cell cycle checkpoints and apoptosis. ( NCI )] (UMLS (NCI) C0812258) E2F1;
E2F1 Gene =Gene or Genome |
- 45. 1-Epoxyethyl-3,4-epoxycyclohexane
- [A synthetic, colorless liquid that is soluble in water. It is used as a reactive diluent for other epoxides and as a monomer in the production of epoxy resins for coatings and adhesives. Occupational exposure of humans to 4-vinyl-1-cyclohexene diepoxide results in skin irritation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0048737) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 95. E3 ligase
- [E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and other proteins, often to mark them for nonlysosomal proteasomal degradation or targeted transport. Ubiquitination requires sequential action of an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3). Ubiquitin is coupled to protein by a peptide bond between the ubiquitin C-terminal glycine and protein lysine alpha-amino groups. Ubiquitination regulates protein degradation, chromatin remodeling, cell cycle progression, differentiation, gene expression, stress response, ribosome biogenesis, antigen presentation, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. ( NCI )] (UMLS (CSP) C0077678) =Amino Acid, Peptide, or Protein; Enzyme ;
=acid aminoacid ligase;
|
- 46. 1-Ethyl N4-sulfanilylcytosin
- [A short-acting, broad-spectrum sulfonamide and a synthetic analog of para-aminobenzoic acid (PABA) with bacteriostatic property. Sulfacytine competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death. ( NCI )] (UMLS (NCI) C0262960) =Organic Chemical; Antibiotic =Sulfanilamides;
[AM650] SULFONAMIDE/RELATED ANTIMICROBIALS =SULFACYTINE 250 MG | - 96. E6
- [Binds to and promotes degradation of p53 protein resulting in disruption of cell cycle regulation. ( NCI )] (UMLS (NCI) C1335332) Papillomavirus Transforming Protein E6;
Viral Protein E6;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 47. 1-Ethyl-1-nitrosourea
- [A nitrosourea with potential antineoplastic activity. Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins, thereby damaging DNA and inducing point mutations. (NCI04) ( NCI )] (UMLS (NCI) C0015111) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 97. E7
- [Complexes with and inactivates Rb protein resulting in disruption of cell cycle regulation. ( NCI )] (UMLS (NCI) C1335333) Papillomavirus Transforming Protein E7;
Viral Protein E7;
=Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 48. 1-ethyl-2-[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)-4-oxothiazolidin-2-ylidenemethyl] pyridinium chloride
- [A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor p53 function. ( NCI )] (UMLS (NCI) C0386286) =Organic Chemical; Pharmacologic Substance ;
| - 98. E7(86-93) Lipopeptide
- [A synthetic peptide (sequence: TLGIVCPI) vaccine consisting of amino acids 86 through 93 of the viral oncoprotein human papillomavirus (HPV) 16 E7. Vaccination with HPV-16 E7:86-93 peptide, which binds to HLA-A* 0201 molecule, may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells positive for HPV-16 E7. ( NCI )] (UMLS (NCI) C0879333) HPV 16 E7:86-93 Peptide Vaccine;
HPV 16E7 86-93 Lipopeptide Vaccine;
HPV-16E7 (86-93) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 49. 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone Monohydrochloride, Monohydrate
- [A peripheral and central respiratory stimulant with a brief duration of action. Doxapram hydrochloride stimulates respiration by an action on chemoreceptors in the carotid arteries and, at increased dosage, stimulates central respiratory centers in the medulla as well as other parts of the brain and spinal cord. This results in an increased tidal volume and a slightly increased respiratory rate. Doxapram hydrochloride may also improve cardiac output probably due to an increased release of catecholamines. This respiratory stimulant is used in postanesthesia respiratory depression. ( NCI )] (UMLS (NCI) C0282152) =Organic Chemical; Pharmacologic Substance ;
=DOXAPRAM;
=DOXAPRAM HYDROCHLORIDE 20 MG/ML;
| - 99. E7(86-93) Lipopeptide/HPV-16 E7(12-20) Peptide Vaccine/Montanide ISA-51
- (UMLS (NCI) C0879335) =Therapeutic or Preventive Procedure
|
- 50. 1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]pyrrolidine
- [A drug that blocks the effects of estrogen. ( NCI )] (UMLS (NCI) C0139560) =Organic Chemical; Pharmacologic Substance
| - 100. E7010
- (UMLS (NCI) C0656781) =Organic Chemical; Pharmacologic Substance ;
|
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