- 2801. Divergent of Neuregulin 1
- [Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0540587) =Amino Acid, Peptide, or Protein; Neuroreactive Substance or Biogenic Amine ;
| - 2851. DIZOCILPINE
- [10,11-dihydro-5-methyldibenzocyclohepten -5,10-imine; PCP analog, anticonvulsant, and excitatory aminoacid antagonist that acts on the calcium channel site of NMDA receptors; USP lists as a neuroprotectant. ( CSP )] (UMLS (NCI) C0079245) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
cycloheptane |
- 2802. Divergent Strabismus
- [A form of ocular misalignment where the visual axes diverge inappropriately. For example, medial rectus muscle weakness may produce this condition as the affected eye will deviate laterally upon attempted forward gaze. An exotropia occurs due to the relatively unopposed force exerted on the eye by the lateral rectus muscle, which pulls the eye in an outward direction. ( MSH )] (UMLS (NCI) C0015310) =Disease or Syndrome ;
=Estrabismo;
| - 2852. dizygotic twin
- [two offspring developed from two separate ova fertilized at the same time; they may be of the same or different sex, and they have different genomes. ( CSP )] (UMLS (CSP) C0041429) =Family Group =twin/multiplet;
|
- 2803. Divergent Upstream Protein
- [DNA Mismatch Repair Protein MSH3, encoded by the MSH3 gene (MutS family), is a 127-kD mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI) ( NCI )] (UMLS (NCI) C0210994) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2853. Dizziness
- [Dizziness is a medically indistinct term used to describe a variety of conditions such as lightheadedness, unsteadiness, giddiness, a sense of turning, spinning or rocking. ( NCI )] (UMLS (NCI) C0012833) =Sign or Symptom ;
=Sensation Disorders;
|
- 2804. Diversion Program
- [A type of program designed to assist individuals and families to address diverse issues such as alcohol and drug abuse, child disobedience, behavioral deviations, misdemeanor and felony. Essential components of the program include but are not limited to: information and referral, case management, advocacy, short term support, help in identifying and assessing the services most appropriate to meet the needs of the individual and family. The program helps to guide each individual towards a positive understanding, acceptance and change of the problems at hand whereby the health and safety of the public is maintained. ( NCI )] (UMLS (NCI) C0680744) =Intellectual Product
| - 2854. DIZZINESS AND GIDDINESS
- [ ] (UMLS (ICD9CM) C0476206) =Sign or Symptom
|
- 2805. Diverticula of small intestine
- (UMLS (ICD9CM) C0267498) =Disease or Syndrome ;
| - 2855. DJ
- [A country in Eastern Africa, bordering the Gulf of Aden and the Red Sea, between Eritrea and Somalia. (NCI) ( NCI )] (UMLS (NCI) C0012836) =Geographic Area ;
|
- 2806. Diverticular disease
- [A condition marked by small sacs or pouches (diverticula) in the walls of an organ such as the stomach or colon. These sacs can become inflamed and cause a condition called diverticulitis, which may be a risk factor for certain types of cancer.(NCI)] (UMLS (ICPC) C1510475) (Diverticular disease; HESTEETAKO ERITASUNA DIBERTIKULARRA; Divertikelsygdom/divertikulit; Diverticulose/diverticulitis; DIVERTIKULOOSI; Maladie diverticulaire intest; Divertikulose/Divertikulitis; maxalot divertikulariot shel hamei; diverticulum-betegseg; Malattia diverticolare; DIVERTIKKEL-SYKDOM I TARMEN; Doenca diverticular; Enf diverticulares del intestino; DIVERTIKELSJUKDOM) Diverticula of intestine; Diverticular Disorder; Diverticulose/diverticulitis; diverticulosis; diverticulum-betegseg; DIVERTIKELSJUKDOM; Divertikelsygdom/divertikulit; DIVERTIKKEL-SYKDOM I TARMEN; DIVERTIKULOOSI; Divertikulose/Divertikulitis; Doenca diverticular; Enf diverticulares del intestino; HESTEETAKO ERITASUNA DIBERTIKULARRA; Maladie diverticulaire intest; Malattia diverticolare; maxalot divertikulariot shel hamei =Disease or Syndrome; Anatomical Abnormality =Body System, Gastrointestinal; Diagnosis/Diseases Component
| - 2856. DJ-927
- [A semi-synthetic orally-available taxane derivative with potent antineoplastic properties. DJ-927 binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents a poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. DJ-927I is more potent than paclitaxel and docetaxel and is the first oral taxane derivative. (NCI04) ( NCI )] (UMLS (NCI) C1313820) =Organic Chemical; Pharmacologic Substance ;
|
- 2807. Diverticulitis
- [Inflammation of a DIVERTICULUM or diverticula. ( MSH )] (UMLS (NCI) C0012813) =Disease or Syndrome ;
=Pathologic Process;
| - 2857. DKFZP564P2063
- [Epidermal Growth Factor-Like Protein 6, encoded by the human EGFL6 gene, is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0911758) EGF Repeat-Containing Protein 6;
EGFL6;
EGFL6 Protein;
EGF-Like 6;
Epidermal Growth Factor Repeat Containing Protein;
Epidermal Growth Factor-Like Protein 6;
MAEG;
MAM- and EGF-Containing Protein;
MAM Domain- and EGF Domain-Containing Protein;
W80 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2808. Diverticulitis of colon with hemorrhage
- [ ] (UMLS (ICD9CM) C0156169) =Disease or Syndrome ;
| - 2858. DKFZP586I1419
- [With highest expression in kidney, heart, placenta, and lung by human TAZ Gene, 400-aa 45-kDa Transcriptional Coactivator with PDZ-Binding Motif contains a putative N-terminal 14-3-3 protein-binding motif, a central WW domain, and a C-terminal PDZ-binding motif and 2-stranded coiled-coil. The PDZ-binding domain localizes TAZ to discrete nuclear foci and is required for TAZ-stimulated gene transcription; it also mediates TAZ interaction with SLC9A3R2. Interaction with 14-3-3 appears to require TAZ phosphorylation on a specific serine residue; phosphorylation reduces TAZ transcriptional coactivation by inducing nuclear export through interaction with 14-3-3. TAZ shares 91% identity with mouse Taz and 45% identity with YAP. (NCI) ( NCI )] (UMLS (NCI) C1336798) TAZ;
Transcriptional Coactivator with PDZ-Binding Motif;
WW Domain Containing Transcription Regulator 1;
WWTR1 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2809. Diverticulitis of colon without mention of hemorrhage
- [ ] (UMLS (ICD9CM) C0156167) =Disease or Syndrome ;
| - 2859. DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol Monohydrochloride
- [The hydrochloride salt form of mefloquine, a piperidinyl quinidine with antimalarial activity. Although the exact mechanism of mefloquine hydrochloride is largely unknown, this agent acts as a blood schizonticide and probably exert its actions by interacting with the phospholipid bilayer, thereby interfering with the stability of the cell membrane and causing cell lysis. Mefloquine hydrochloride is active against Plasmodium falciparum and Plasmodium vivax. ( NCI )] (UMLS (NCI) C0282398) =Organic Chemical; Pharmacologic Substance ;
=MEFLOQUINE;
=MEFLOQUINE HYDROCHLORIDE 250 MG;
|
- 2810. Diverticulitis of small intestine (without mention of hemorrhage)
- [ ] (UMLS (ICD9CM) C0156163) =Disease or Syndrome ;
| - 2860. DL-Phenylalanine
- [A racemic mixture of phenylalanine, an aromatic amino acid with antidepressant, analgesic and appetite suppressant properties. The antidepressant effect of DL-phenylalanine may be accounted for by its precursor role in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects. This agent also plays a role in alleviating mood swings of premenstrual syndrome (PMS), increasing energy and mental alertness and heighten the ability to focus in individuals with attention deficit hyperactivity disorder (ADHD). ( NCI )] (UMLS (NCI) C0772277) PHENYLALANINE, DL-;
PHENYLALANINE,DL-;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 2811. Diverticulitis of small intestine with hemorrhage
- [ ] (UMLS (ICD9CM) C0156165) =Disease or Syndrome ;
| - 2861. DL717
- (UMLS (NCI) C0065187) =Organic Chemical; Pharmacologic Substance ;
|
- 2812. Diverticulosis of colon (without mention of hemorrhage)
- [ ] (UMLS (ICD9CM) C0156166) =Disease or Syndrome ;
| - 2862. DLEU1
- [Expressed in testis, thymus, small intestine, prostate, spleen, peripheral blood lymphocytes, and ovary and encoded by human DLEU1 Gene, DLEU1 Protein is a 72-amino acid putative tumor suppressor protein for BCLL. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1333222) DLEU1 Protein;
Leukemia Associated Protein 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2813. Diverticulosis of colon with hemorrhage
- [ ] (UMLS (ICD9CM) C0156168) =Disease or Syndrome ;
| - 2863. DLEU2
- [Expressed in thymus and testis and encoded by human DLEU2 Gene, DLEU2 Protein is an 84-amino acid 10-kD putative tumor suppressor protein. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1333224) DLEU2 Protein;
Leukemia Associated Protein 2 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2814. Diverticulosis of small intestine (without mention of hemorrhage)
- [ ] (UMLS (ICD9CM) C0156162) =Disease or Syndrome ;
| - 2864. dlg protein
- [ ] (UMLS (CSP) C0165897) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 2815. Diverticulosis of small intestine with hemorrhage
- [ ] (UMLS (ICD9CM) C0156164) =Disease or Syndrome ;
| - 2865. DM
- [An island between the Caribbean Sea and the North Atlantic Ocean, about one-half of the way from Puerto Rico to Trinidad and Tobago. (NCI) ( NCI )] (UMLS (NCI) C0013013) =Geographic Area
|
- 2816. Diverticulum
- (UMLS (HL7) C1546602) =Intellectual Product =Specimen Source Codes;
| - 2866. DMDT
- [An insecticide. Methoxychlor has estrogenic effects in mammals, among other effects. ( MSH )] (UMLS (CSP) C0025685) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 2817. Diverticulum
- [A pathological condition manifested as a pouch or sac opening from a tubular or saccular organ. ( MSH )] (UMLS (NCI) C0012817) =Anatomical Abnormality ;
=Digestive Diseases;
Pathological Conditions, Anatomical =Colon Diverticulum;
Diverticulum, Esophageal;
Diverticulum, Stomach | - 2867. DMDT (dimethoxydiphenyltrichloroethane)
- [ ] (UMLS (CSP) C0598156) =Organic Chemical; Hazardous or Poisonous Substance
|
- 2818. DIVERTICULUM OF BLADDER
- [ ] (UMLS (ICD9CM) C0156273) =Disease or Syndrome ;
| - 2868. DMF
- (UMLS (NCI) C0060056) =Therapeutic or Preventive Procedure ;
|
- 2819. DIVERTICULUM OF PHARYNX
- [ ] (UMLS (ICD9CM) C0392485) =Congenital Abnormality
| - 2869. DMI KETO NT ST UNCNTRLD
- [ ] (UMLS (ICD9CM) C0375118) =Disease or Syndrome
|
- 2820. Divination
- (UMLS (HL7) C1552046) =Idea or Concept =Religious Affiliation;
| - 2870. DMI KETOACD UNCONTROLD
- [ ] (UMLS (ICD9CM) C0375120) =Disease or Syndrome
|
- 2821. diving
- [An activity in which the organism plunges into water. It includes scuba and bell diving. Diving as natural behavior of animals goes here, as well as diving in decompression experiments with humans or animals. ( MSH )] (UMLS (CSP) C0012823) =Daily or Recreational Activity ;
| - 2871. DMI WO CMP NT ST UNCNTRL
- [ ] (UMLS (ICD9CM) C0375114) =Disease or Syndrome
|
- 2822. diving reflex
- [ ] (UMLS (CSP) C0599289) =Organism Function
| - 2872. DMI WO CMP UNCNTRLD
- [ ] (UMLS (ICD9CM) C0375116) =Disease or Syndrome
|
- 2823. diving/swimming
- [to plunge into water intentionally or to propel oneself in water by natural means. ( CSP )] (UMLS (CSP) C0178599) =Organism Attribute =body movement;
| - 2873. DMII KETO NT ST UNCNTRLD
- [ ] (UMLS (ICD9CM) C0375117) =Disease or Syndrome
|
- 2824. DIVIS GLOSSOPHARYNG NERV
- [ ] (UMLS (ICD9CM) C0196608) =Therapeutic or Preventive Procedure
| - 2874. DMII KETOACD UNCONTROLD
- [ ] (UMLS (ICD9CM) C0375119) =Disease or Syndrome
|
- 2825. Division
- (UMLS (HL7) C1547541) =Idea or Concept =Organization Unit Type;
| - 2875. DMII WO CMP NT ST UNCNTR
- [ ] (UMLS (ICD9CM) C0375113) =Disease or Syndrome
|
- 2826. Division of anal sphincter
- [ ] (UMLS (ICD9CM) C0176870) =Therapeutic or Preventive Procedure
| - 2876. DMII WO CMP UNCNTRLD
- [ ] (UMLS (ICD9CM) C0375115) =Disease or Syndrome
|
- 2827. Division of endometrial synechiae
- (UMLS (ICD9CM) C0195436) =Therapeutic or Preventive Procedure
| - 2877. DMP 266
- [ ] (UMLS (CSP) C0387216) =Organic Chemical; Pharmacologic Substance ;
|
- 2828. Division of intraspinal nerve root
- [Surgical interruption of a spinal or cranial nerve root. (From Dorland, 28th ed) ( MSH )] (UMLS (ICD9CM) C0282615) =Therapeutic or Preventive Procedure ;
| - 2878. DMP 777
- [ ] (UMLS (CSP) C0539069) =Organic Chemical; Pharmacologic Substance
|
- 2829. Division of joint capsule, ligament, or cartilage
- [ ] (UMLS (ICD9CM) C0177507) =Therapeutic or Preventive Procedure
| - 2879. DN-101
- [An oral high dose formulation of calcitriol, the biologically active form of Vitamin D. Acting as a ligand for the Vitamin D receptor (VDR), DN-101 binds to the VDR inhibiting VDR-regulated gene transcription involved in cell proliferation, differentiation and apoptosis. (NCI) ( NCI )] (UMLS (NCI) C1328169) Ro 21-5535 =Organic Chemical; Pharmacologic Substance; Vitamin
|
- 2830. Division of joint capsule, ligament, or cartilage of elbow
- [ ] (UMLS (ICD9CM) C0177509) =Therapeutic or Preventive Procedure
| - 2880. DNA (Cytosine-5-)-Methyltransferase 3 Beta
- [DNA Methyltransferase 3B, encoded by the human DNMT3B gene, is required for genome wide de novo methylation and is essential for development. This nuclear protein interacts with UBL1 and UBE2I9. Six isoforms (1, 2, 3, 4, 5 and 6) are produced by alternative splicing but isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate. Defects in DNMT3B are a cause of immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. ICF is biochemically characterized by hypomethylation of CpG sites in some regions of heterochromatin. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C1452577) DNA Methyltransferase 3B;
DNA Methyltransferase HsaIIIB;
DNA MTase HsaIIIB;
DNMT3B;
DNMT3B Protein;
EC 2.1.1.37;
ICF;
M.HsaIIIB =Amino Acid, Peptide, or Protein; Enzyme |
- 2831. Division of joint capsule, ligament, or cartilage of foot and toe
- [ ] (UMLS (ICD9CM) C0177515) =Therapeutic or Preventive Procedure
| - 2881. DNA (Cytosine-5-)-Methyltransferase 3 Beta Gene
- [This gene plays a role in embryonic development, imprinting, and X-chromosome inactivation. ( NCI )] (UMLS (NCI) C1333242) DNMT3B;
DNMT3B Gene;
=Gene or Genome ;
|
- 2832. Division of joint capsule, ligament, or cartilage of hand and finger
- [ ] (UMLS (ICD9CM) C0177511) =Therapeutic or Preventive Procedure
| - 2882. DNA Alkylation
- [DNA Alkylation involves the addition of alkyl groups to any of several vulnerable positions on all four of the DNA bases. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. (Gene Ontology and NCI) ( NCI )] (UMLS (NCI) C1158483) =Genetic Function
|
- 2833. Division of joint capsule, ligament, or cartilage of hip
- [ ] (UMLS (ICD9CM) C0177512) =Therapeutic or Preventive Procedure
| - 2883. DNA Alteration
- [any detectable and heritable change in the genetic material that causes a change in the genotype and which is transmitted to daughter cells and to succeeding generations. ( CSP )] (UMLS (NCI) C0596611) =Genetic Function =Genetics;
Molecular Genetics =Aberrant Chromosome;
DNA damage;
gene deletion;
gene duplication;
suppressor mutation;
Frameshift;
point mutation;
LOH;
mutant |
- 2834. Division of joint capsule, ligament, or cartilage of knee
- [ ] (UMLS (ICD9CM) C0177513) =Therapeutic or Preventive Procedure
| - 2884. DNA amplification
- [The process by which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment. [ISBN:0721601464] ( GO )] (UMLS (CSP) C0683230) =Genetic Function ;
|
- 2835. Division of joint capsule, ligament, or cartilage of other specified site
- [ ] (UMLS (ICD9CM) C0177516) =Therapeutic or Preventive Procedure
| - 2885. DNA analysis
- [Any DNA based laboratory tests. ( NCI )] (UMLS (CSP) C0200898) =Laboratory Procedure
|
- 2836. Division of joint capsule, ligament, or cartilage of shoulder
- [ ] (UMLS (ICD9CM) C0177508) =Therapeutic or Preventive Procedure
| - 2886. DNA bank
- [A collection of DNA molecules that have been cloned in vectors. ( NCI )] (UMLS (CSP) C0872147) DNA library;
Library =Gene or Genome; Nucleic Acid, Nucleoside, or Nucleotide |
- 2837. Division of joint capsule, ligament, or cartilage of wrist
- [ ] (UMLS (ICD9CM) C0177510) =Therapeutic or Preventive Procedure
| - 2887. DNA Binding
- [Used in reference to proteins or low molecular weight solutes (ligands) that interact specifically with DNA, in either a DNA-sequence dependent or independent fashion. ( NCI )] (UMLS (NCI) C1148673) DNA Binding Interaction =Genetic Function ;
|
- 2838. Division of joint capsule, ligament, or cartilage, unspecified site
- [ ] (UMLS (ICD9CM) C0376072) =Therapeutic or Preventive Procedure
| - 2888. DNA binding protein
- [diverse group of viral and genetic regulatory proteins which bind in a sequence-specific manner to DNA, and share common structural motifs such as the "zinc-finger," "helix-turn-helix," and "leucine zipper." ( CSP )] (UMLS (CSP) C0012940) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=binding protein;
=transcription factor;
immediate early protein;
HIF 1;
c-fos Protein;
EBP |
- 2839. Division of laryngeal nerve
- [ ] (UMLS (ICD9CM) C0196609) =Therapeutic or Preventive Procedure
| - 2889. DNA biosynthesis
- [process by which a DNA molecule is duplicated in vivo, or studies of the natural process in vitro; for artificial synthesis, see NUCLEIC ACID CHEMICAL SYNTHESIS and its narrower terms. ( CSP )] (UMLS (CSP) C0598312) =Genetic Function =cell cycle;
nucleic acid biosynthesis =replicon;
DNA replication origin;
|
- 2840. Division of muscle, tendon, and fascia
- [ ] (UMLS (ICD9CM) C0177615) =Therapeutic or Preventive Procedure
| - 2890. DNA chemical synthesis
- [ ] (UMLS (CSP) C1328870) DNA synthesis =Laboratory Procedure; ;
|
- 2841. Division of muscle, tendon, and fascia of hand
- [ ] (UMLS (ICD9CM) C0177581) =Therapeutic or Preventive Procedure
| - 2891. DNA damage
- [drug or radiation effects on DNA that interfere with normal function, including conformational distortions and covalent gene mutations. ( CSP )] (UMLS (CSP) C0012860) =Cell or Molecular Dysfunction ;
=DNA Alteration;
=Cyclobutane Pyrimidine Dimer |
- 2842. DIVISION OF PENILE ADHES
- (UMLS (ICD9CM) C0403331) =Therapeutic or Preventive Procedure
| - 2892. DNA Damage Repair
- [reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions; the major repair mechanisms are excision repair, photoreactivation repair, and post-replication repair. ( CSP )] (UMLS (NCI) C0012899) =Genetic Function ;
=nucleic acid metabolism;
|
- 2843. Division of sympathetic nerve or ganglion
- [ ] (UMLS (ICD9CM) C0176085) =Therapeutic or Preventive Procedure
| - 2893. DNA directed DNA polymerase
- [Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA. EC 2.7.7.7 or EC 2.7.7.49 ( NCI )] (UMLS (CSP) C0012892) =Amino Acid, Peptide, or Protein; Enzyme =EC 2.7.7;
|
- 2844. Division of thyroid isthmus
- (UMLS (ICD9CM) C0193777) =Therapeutic or Preventive Procedure
| - 2894. DNA directed RNA polymerase
- [RNA polymerases comprise a group of enzymes that catalyze extension, one nucleotide at a time, of the 3 prime-end of an RNA strand along a complementary DNA template. ( NCI )] (UMLS (CSP) C0035681) =Amino Acid, Peptide, or Protein; Enzyme =EC 2.7.7;
|
- 2845. Division of trigeminal nerve
- [ ] (UMLS (ICD9CM) C1306506) TRIGEMINAL NERV DIVISION =Therapeutic or Preventive Procedure
| - 2895. DNA Directed RNA Polymerase II Polypeptide A
- [Encoded by human POLR2A Gene (RNA Polymerase Beta Prime Chain Family), nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A is the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair. ( NCI )] (UMLS (NCI) C1333229) DNA-Directed RNA Polymerase II Largest Subunit;
hRPB220;
hsRPB1;
POLR2;
POLR2A;
POLRA;
Polymerase (RNA) II (DNA Directed) Polypeptide A (220kD);
Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa;
RNA Polymerase II 220 kD Subunit;
RPB1;
RPBh1;
RpIILS;
RPO2;
RPOL2 =Amino Acid, Peptide, or Protein; Enzyme |
- 2846. Division or crushing of other cranial and peripheral nerves
- (UMLS (ICD9CM) C0012827) =Therapeutic or Preventive Procedure ;
| - 2896. DNA Double-Strand Break Repair and V(D)J Recombination Protein XRCC4
- [X-Ray Repair Cross Complementing Protein 4, encoded by the XRCC4 gene, functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. XRCC4 functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. XRCC4 is a ubiquitously expressed protein. Alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. (NCI) ( NCI )] (UMLS (NCI) C1337026) DNA Repair Protein XRCC4;
X-Ray Repair Cross Complementing Protein 4;
X-Ray Repair, Complementing Defective, Repair In Chinese Hamster;
XRCC4 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 2847. divorce
- [Legal dissolution of an officially recognized marriage relationship. ( MSH )] (UMLS (CSP) C0012828) =Finding ;
| - 2897. DNA Excision Repair Protein ERCC-1
- [DNA excision repair protein ERCC-1, encoded by the ERCC1 gene, is a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Its C-terminal is essential for enzymatic activity and the central region is involved in protein-protein interactions. The ERCC1 gene is involved in UV cross-link repair and nucleotide excision repair (NER). With p53 monitoring DNA damage, either XPA loads and possibly orients an incision complex, containing ERCC1 and other repair factors, to the site of DNA damage or XPA, ERCC1, and ERCC4 proteins form a ternary complex that participates in both damage recognition and incision activities. In the absence of DNA damage, the complex moved freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC1/XPF to engage the complex in a single repair event. Afterwards, the complex regains mobility. (From OMIM 126380 and NCI) ( NCI )] (UMLS (NCI) C1333483) ERCC1;
Excision Repair Cross-Complementing 1;
=Amino Acid, Peptide, or Protein; Enzyme |
- 2848. divorce/separation
- [action or instance of legally dissolving a marriage or cessation of cohabitation between a married couple by mutual agreement or judicial decree. ( CSP )] (UMLS (CSP) C0178600) =Human-caused Phenomenon or Process =marriage/marital status;
| - 2898. DNA Excision Repair Protein ERCC-4
- [DNA Excision Repair Protein ERCC-4, encoded by the ERCC4 gene, is a DNA repair protein. Nucleotide excision repair (NER) involves incision of a DNA strand on each side of a lesion. The two incisions made during NER are catalyzed by separate DNA endonucleases. A tight protein complex formed between ERCC4 and ERCC1 acts as a structure-specific endonuclease for the 5-prime incision during repair. Without DNA damage, this complex moves freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC4/ERCC1 due to engagement of the complex in a single repair event after assembly of individual nucleotide excision repair factors at sites of DNA damage in a distributive fashion. Causative mutations in the ERCC4 gene and strongly reduced levels of encoded protein can be identified in patients with xeroderma pigmentosum type F. (From OMIM and NCI) ( NCI )] (UMLS (NCI) C1333231) ERCC4;
RAD1;
XPF;
=Amino Acid, Peptide, or Protein; Enzyme |
- 2849. Divorced
- [A person whose marriage has been legally dissolved and has not remarried. ( NCI )] (UMLS (HL7) C0086170) =Finding =marital status;
MaritalStatus | - 2899. DNA Excision Repair Protein ERCC-5
- [XPG-Complementing Protein, encoded by the ERCC5 gene is involved in transcription-coupled repair of UV-induced DNA damage. It is a single-strand specific DNA endonuclease that nicks damaged DNA 3-prime to the lesion in nucleotide excision repair as a result of the combined action of the XPB helicase and XPD helicase following sequential assembly of repair proteins at the DNA damage site. In addition, it associates with CSA, CSB, or both proteins at the transcriptional pause sites to facilitate the resumption of transcript elongation without aborting the associated nascent transcript by pushing the stalled RNA polymerase II either forward or backward not only from the damaged site but also from some natural transcription pause sites. Mutational inactivation of XPG causes Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. (from OMIM 133530, LocusLink 2073 and NCI) ( NCI )] (UMLS (NCI) C1333232) DNA-Repair Protein Complementing XP-G Cells;
ERCC5;
ERCM2;
UVDR;
Xeroderma Pigmentosum Group G Complementing Protein;
XPG;
XPGC;
XPG-Complementing Protein =Amino Acid, Peptide, or Protein; Enzyme |
- 2850. Dizatrifone
- (UMLS (NCI) C0634883) =Organic Chemical; Pharmacologic Substance
| - 2900. DNA Exonuclease
- [family of enzymes that catalyze the exonucleolytic cleavage of DNA; includes members of the class EC 3.1.11 that produce 5'-phosphomonoesters as cleavage products. ( CSP )] (UMLS (NCI) C0015284) =Amino Acid, Peptide, or Protein; Enzyme =exonuclease;
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