- 1. (+-)-m-((Ethylamino)-1-hydroxyethyl)phenyl Pivalate
- [A prodrug of etilefrine, an adrenergic agonist with vasoconstrictive activity. Etilefrine pivalate is hydrolyzed to etilefrine, which binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to a decrease in venous pooling and increase in blood pressure. This agent may also stimulate beta-1 adrenergic receptors leading to positive chronotropic and inotropic effects. ( NCI )] (UMLS (NCI) C0059855) =Organic Chemical
| - 51. 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone
- [A sedative, hypnotic agent that was used for insomnia, but was taken off of the market, in the U.S., in 1983 due to its high risk of abuse.(NCI) ( NCI )] (UMLS (NCI) C0025627) =Organic Chemical; Pharmacologic Substance ;
|
- 2. (+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Hydrochloride
- [The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta1-adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. ( NCI )] (UMLS (NCI) C0700606) =Organic Chemical; Pharmacologic Substance ;
=esmolol;
=ESMOLOL HYDROCHLORIDE 10 MG/ML;
ESMOLOL HYDROCHLORIDE 250 MG/ML;
| - 52. 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone
- [A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension. ( NCI )] (UMLS (NCI) C0025854) =Organic Chemical; Pharmacologic Substance ;
=[CV701] THIAZIDES/RELATED DIURETICS;
quinazoline;
sulfonamide;
=METOLAZONE 0.5 MG;
METOLAZONE 10 MG;
METOLAZONE 2.5 MG;
METOLAZONE 5 MG;
|
- 3. (+/-)-2-(1-Methylethyl)-4-(1-methylethylidene)-2-cyclohexen-1-ol
- (UMLS (NCI) C0218671) =Organic Chemical; Pharmacologic Substance ;
| - 53. 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine
- [A synthetic derivative of thienobenzodiazepine with antipsychotic properties. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through a combination of dopamine and serotonin type 2 antagonism. ( NCI )] (UMLS (NCI) C0171023) =Organic Chemical; Pharmacologic Substance ;
=Pirenzepine;
[CN709] ANTIPSYCHOTICS, OTHER =olanzapine 10 MG Disintegrating Tablet;
OLANZAPINE 10 MG;
OLANZAPINE 2.5 MG;
OLANZAPINE 7.5 MG;
OLANZAPINE 5 MG;
OLANZAPINE 15 MG;
OLANZAPINE 20 MG |
- 4. (+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1)
- [The maleate salt form of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI04) ( NCI )] (UMLS (NCI) C0795660) Rosiglitazone Maleate;
ROSIGLITAZONE MALEATE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=Rosiglitazone;
=ROSIGLITAZONE MALEATE 4 MG;
ROSIGLITAZONE MALEATE 8 MG;
ROSIGLITAZONE MALEATE 2 MG;
ROSIGLITAZONE MALEATE 1 MG;
| - 54. 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
- [An anticancer drug that belongs to the family of drugs called antiandrogens. ( NCI )] (UMLS (NCI) C0016384) =Organic Chemical; Pharmacologic Substance ;
=Anilides;
[AN000] ANTINEOPLASTICS =FLUTAMIDE 125 MG;
|
- 5. (1-Methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride
- [The hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. At the injection site, mepivacaine hydrochloride acts by binding to specific membrane sodium ion channels in the neuronal cell membranes, thereby inhibiting sodium influx. This leads to a blockage of nerve impulse conduction and results in a loss of sensation. ( NCI )] (UMLS (NCI) C0700542) =Organic Chemical; Pharmacologic Substance =MEPIVACAINE;
=MEPIVACAINE HYDROCHLORIDE 3 %;
MEPIVACAINE HYDROCHLORIDE 1 %;
MEPIVACAINE HYDROCHLORIDE 1.5 %;
MEPIVACAINE HYDROCHLORIDE 2 %;
| - 55. 2-methylacyl-CoA Racemase
- [Human alpha-methylacyl-CoA racemase protein (382 aa, ~42.4 kDa) is encoded by the AMCAR gene (AMACR). This protein is an enzyme that is involved in the beta-oxidation of branched-chain fatty acids. Overexpression of this protein has been found in several carcinomas, thus it is considered an important biomarker in the pathogenesis of breast, prostate, and colon cancers. ( NCI )] (UMLS (NCI) C0666209) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 6. (10^3m)3
- [LITERAL ( NCI )] (UMLS (NCI) C0439243) =Quantitative Concept
| - 56. 2-Methylallyl Chloride
- [A synthetic, flammable, volatile, colorless to straw-colored liquid that is insoluble in water and soluble in chloroform, acetone, alcohol, ether and benzene. It is used primarily as a chemical intermediate in the production of carbofuran, a carbamate insecticide; used in the production of herbicides, plastics, pharmaceuticals, and other organic as well as an additive in textiles and perfumes. When heated to decomposition, it emits toxic fumes of hydrochloric acid and other chlorinated compounds. Contact exposure of this substance causes irritation of the eyes and skin. Inhalation can lead to irritation of the respiratory tract and depression of the central nervous system. Breathing at high levels of 3-chloro-2-methylpropene vapors may induce coughing, gasping, breathing difficulties and extreme respiratory distress, even coma. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047290) =Organic Chemical; Hazardous or Poisonous Substance
|
- 7. (2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester)
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0053902) =Organic Chemical; Pharmacologic Substance ;
| - 57. 20 minutes post challenge
- (UMLS (HL7) C1547069) =Temporal Concept =Time delay post challenge;
|
- 8. (2-Mercaptoethyl)trimethylammonium Iodide S-ester with O,O-diethyl Phosphorothioate, Diethoxyphosphoryl-thiocholine Iodide
- [The iodide salt form of echothiophate, a long-acting cholinesterase inhibitor with parasympathomimetic activity. Echothiophate iodide potentiates the action of endogenous acetylcholine by inhibiting acetylcholinesterase that hydrolyzes acetylcholine. When applied topically to the eye, this agent prolongs stimulation of the parasympathetic receptors at the neuromuscular junctions of the longitudinal muscle of the ciliary body. Contraction of longitudinal muscle pulls on the scleral spur, and opens the trabecular meshwork, thereby increases aqueous humor outflow from the eye and reduces intraocular pressure. ( NCI )] (UMLS (NCI) C0013530) =Organophosphorus Compound; Pharmacologic Substance =Organothiophosphorus Compounds;
ECHOTHIOPHATE =ECHOTHIOPHATE IODIDE 0.03 %;
ECHOTHIOPHATE IODIDE 0.125 %;
ECHOTHIOPHATE IODIDE 0.25 %;
ECHOTHIOPHATE IODIDE 0.06 %;
| - 58. 25 minutes post challenge
- (UMLS (HL7) C1547071) =Temporal Concept =Time delay post challenge;
|
- 9. (2-Mercaptopropionyl)glycine
- [An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. ( NCI )] (UMLS (NCI) C0025405) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=Amino Acids, Sulfur;
GLYCINE;
Unclassified Ingredient Preparations;
=Thiopronine 100 MG;
| - 59. 3 methoxy 4 hydroxyphenylethyleneglycol
- [metabolite of epinephrine and norepinephrine found in blood, brain, CSF, and urine, where it is used as a measure of catecholamine turnover. ( CSP )] (UMLS (CSP) C0025691) =Organic Chemical; Biologically Active Substance ;
=alcohol;
|
- 10. (99m)Tc-Medronate
- [A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with potential bone imaging activity. Upon intravenous administration, skeletal uptake of Tc 99m MDP occurs as a function of skeletal blood flow and is related to osteogenic activity. The medronate moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization. Labeling with Tc 99m allows localization and visualization of areas in which skeletal uptake of Tc 99m is impaired, such as in areas of abnormal osteogenesis. ( NCI )] (UMLS (NCI) C0039416) =Organophosphorus Compound; Indicator, Reagent, or Diagnostic Aid
| - 60. 3 minutes post challenge
- (UMLS (HL7) C1547078) =Temporal Concept =Time delay post challenge;
|
- 11. (99m)Tc-P280
- [A radioconjugate comprised of the small peptide apcitide labeled with the gamma-emitting technetium TC99m (metastable Tc-99). Apcitide binds to platelet glycoprotein (GP) GPIIb/IIIa receptors on the surface of activated platelets. Labeling apcitide with TC99m allows localization of thrombus formation by gamma-ray imaging equipment and the ability to distinguish between old, inactive thrombi and new, active thrombi. ( NCI )] (UMLS (NCI) C0766234) A9504;
Technetium Tc-99m Apcitide;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid | - 61. 3 months (90 days) post challenge
- (UMLS (HL7) C1547077) =Temporal Concept =Time delay post challenge;
|
- 12. (Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase
- [A modified form of asparaginase, an anticancer drug that belongs to the family of drugs derived from enzymes. ( NCI )] (UMLS (NCI) C0071568) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme =[AN000] ANTINEOPLASTICS;
ASPARAGINASE;
Glycol, polyethylene;
(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase =(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase;
PEGASPARGASE 750 UNT/ML;
| - 62. 3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one)
- [An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. ( MSH )] (UMLS (NCI) C0005640) =Organic Chemical; Pharmacologic Substance
|
- 13. *Mass
- [The amount of matter in an object. ( NCI )] (UMLS (HL7) C1306372) Mass =Quantitative Concept =Kind of quantity;
| - 63. 3,4 methylenedioxyamphetamine
- [abused, controlled, serotonergic hallucinogen of the "designer drug" class; probably the active metabolite of MDMA ("ecstasy"). ( CSP )] (UMLS (CSP) C0000379) =Organic Chemical; Pharmacologic Substance ;
|
- 14. *Mass Concentration
- [A concentration unit measured as the mass of solute per volume of mixture. ( NCI )] (UMLS (HL7) C0560150) =Quantitative Concept =Kind of quantity;
| - 64. 3,4 methylenedioxymethamphetamine
- [synthetic adrenergic agonist resembling both amphetamine (a stimulant) and mescaline (a hallucinogen); "designer drug" once touted as potentially psychotherapeutic, but now a controlled substance considered a drug of abuse. ( CSP )] (UMLS (CSP) C0115471) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =Amfetamine;
hallucinogen |
- 15. *Mass Concentration Ratio
- (UMLS (HL7) C1264678) =Quantitative Concept =Kind of quantity;
| - 65. 3-(Methylseleno)-l-alanine
- (UMLS (NCI) C0074299) =Organic Chemical; Pharmacologic Substance ;
|
- 16. *Mass Fraction
- [Quotient of the mass of a component and the total mass of the system containing the component. For clinical chemistry the term component is recommended, IS0 uses substance. For clinical chemistry the term system is recommended, IS0 uses mixture. ( NCI )] (UMLS (HL7) C1264663) Mass Fraction;
=Quantitative Concept =Kind of quantity;
| - 66. 3-methyl TTNEB
- [An anticancer drug used to decrease the growth of some types of cancer cells. Also called bexarotene. ( NCI )] (UMLS (NCI) C0765273) 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid;
Bexarotene;
BEXAROTENE PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Retinoic Acid Agent =BEXAROTENE 75 MG;
BEXAROTENE 1 % |
- 17. *Mass Increment
- (UMLS (HL7) C1264694) =Quantitative Concept =Kind of quantity;
| - 67. 3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide
- [peripheral vasodilator that reduces blood pressure; diazoxide also has antidiuretic and hypoglycemic effects. ( CSP )] (UMLS (NCI) C0012022) =Organic Chemical; Pharmacologic Substance =antihypertensive agent;
benzothiadiazine;
[CV490] ANTIHYPERTENSIVES, OTHER;
thiazide;
[HS503] ANTIHYPOGLYCEMICS;
=DIAZOXIDE 15 MG/ML;
DIAZOXIDE 50 MG/ML;
DIAZOXIDE 50 MG;
|
- 18. *Mass Rate
- (UMLS (HL7) C1264669) =Quantitative Concept =Kind of quantity;
| - 68. 3-Methylglutaconyl-CoA Hydratase
- [AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. (LocusLink) ( NCI )] (UMLS (NCI) C0066377) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 19. *Mass Ratio
- (UMLS (HL7) C1264679) =Quantitative Concept =Kind of quantity;
| - 69. 30 minutes post challenge
- (UMLS (HL7) C1547075) =Temporal Concept =Time delay post challenge;
|
- 20. 1 minute post challenge
- (UMLS (HL7) C1547067) =Temporal Concept =Time delay post challenge;
| - 70. 30m
- [Mandibular right first molar mesial hemisection ( HL7V3.0 )] (UMLS (HL7) C1552109) =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 21. 1 month (30 days) post challenge
- (UMLS (HL7) C1547066) =Temporal Concept =Time delay post challenge;
| - 71. 31m
- [Mandibular right second molar mesial hemisection ( HL7V3.0 )] (UMLS (HL7) C1552111) =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 22. 1,1'-[(methylethanediylidene)dinitrilo)diguanidine
- [A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0026251) =Organic Chemical; Pharmacologic Substance ;
=hydrazone;
| - 72. 32m
- [Mandibular right third molar mesial hemisection ( HL7V3.0 )] (UMLS (HL7) C1552113) =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 23. 1,2-(methylenedioxy)benzene
- [formula is C7H6O2; synonyms include: (methylenedioxy)benzene; o-methylenedioxybenzene; benzodioxole; 1,2-(methylenedioxy)benzene; 1,3-dioxaindan; 1,3-dioxindan; 3,4-methylenedioxybenzene. ( CSP )] (UMLS (CSP) C0043896) =Organic Chemical =oxygenous heterocyclic compound;
| - 73. 4 minutes post challenge
- (UMLS (HL7) C1547080) =Temporal Concept =Time delay post challenge;
|
- 24. 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
- [noncardioselective beta adrenergic antagonist; used in treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hyperthyroidism, migraine; pheochromocytoma, etc. ( CSP )] (UMLS (NCI) C0033497) =Organic Chemical; Pharmacologic Substance ;
=[CV300] ANTIARRHYTHMICS;
Propanolamines;
beta antiadrenergic agent;
naphthylamine;
coronary vasodilator;
[CV100] BETA-BLOCKERS/RELATED =2-Propanol-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy) Hydrochloride;
PROPRANOLOL 10 MG;
PROPRANOLOL 40 MG;
| - 74. 4'-Methylgenistein
- [An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer. ( NCI )] (UMLS (NCI) C0053622) =Organic Chemical; Pharmacologic Substance ;
|
- 25. 1-(3-Mercaptopropionic acid)-8-D-arginine Vasopression Monoacetate
- [An analogue of the hormone vasopressin with antidiuretic and antihemorrhagic properties. Desmopressin acetate has selective affinity for the V2 receptor and acts on the distal kidney tubule by increasing the cellular permeability thereby stimulating water reabsorption. This antidiuretic agent is used in the treatment of central diabetes insipidus. An unrelated action of desmopressin acetate is to increases circulating factor VIII and is used in patients with haemophilia and von Willebrand's disease. ( NCI )] (UMLS (NCI) C0086135) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Hormone =1-Deamino-8-D-arginine Vasopressin;
=DESMOPRESSIN ACETATE 150 MCG/ACTUAT;
DESMOPRESSIN ACETATE 0.1 MG/ML;
DESMOPRESSIN ACETATE 4 MCG/ML | - 75. 4,4'-Methylenebisbenzenamine
- [A yellowish to brownish colored crystalline solid aromatic amine with a faint amine-like odor that is unstable in the presence of light or air and emits toxic fumes of aniline and nitrogen oxides when heated to decomposition. 4,4'-Methylenedianiline is primarily used in industry as a chemical intermediate in the production of 4,4-methylenedianiline diisocyanates and polyisocyanates, but is also used as a cross-linking agent for the determination of tungsten and sulfates, and as a corrosion inhibitor. Exposure to this substance irritates the skin and eyes and causes liver damage. 4,4'-Methylenedianiline is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047805) =Organic Chemical; Hazardous or Poisonous Substance ;
|
- 26. 1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride
- [The hydrochloride salt form of maprotiline, a tetracyclic antidepressant closely related to the tricyclic antidepressants with adrenergic activity and sedative properties. Maprotiline hydrochloride exerts its effect by blocking the re-uptake of norepinephrine, thereby increasing the synaptic concentration of norepinephrine in the central nervous system and subsequently prolonging the action of norepinephrine on central receptors. ( NCI )] (UMLS (NCI) C0700455) =Organic Chemical; Pharmacologic Substance =MAPROTILINE;
=MAPROTILINE HYDROCHLORIDE 25 MG;
MAPROTILINE HYDROCHLORIDE 50 MG;
MAPROTILINE HYDROCHLORIDE 75 MG | - 76. 4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic Acid
- (UMLS (NCI) C0211503) =Organic Chemical
|
- 27. 1-Methoxy-2-nitrobenzene
- [A synthetic, colorless or slightly yellow liquid that is insoluble in water and soluble in most organic solvents. It is used primarily as a precursor to o-anisidine, which is used extensively in the synthesis of azo dyes. 2-Nitroanisole is also used as an intermediate for the preparation of pharmaceuticals products. The primary routes of potential human exposure to 2-nitroanisole are dermal contact, ingestion and inhalation. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0046435) =Organic Chemical; Hazardous or Poisonous Substance
| - 77. 4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
- [A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied for cancer prevention. ( NCI )] (UMLS (NCI) C0538927) =Organic Chemical; Pharmacologic Substance =sulfonamide;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =CELECOXIB 100 MG;
CELECOXIB 200 MG;
CELECOXIB 400 MG |
- 28. 1-Methyl-1-nitrosourea
- [methylated nitrosourea compound with alkylating, carcinogenic, and mutagenic properties. ( CSP )] (UMLS (NCI) C0025803) =Organic Chemical; Hazardous or Poisonous Substance ;
=Cancer Causing Agents;
nitrosourea | - 78. 4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide
- [A substance that is being studied as a treatment for pain and other side effects of cancer therapy. It belongs to the family of drugs called COX-2 inhibitors. ( NCI )] (UMLS (NCI) C0913246) Valdecoxib;
VALDECOXIB PREPARATION;
VALDECOXIB UNIDENTIFIED;
=Organic Chemical; Pharmacologic Substance ;
=[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
Unclassified Ingredients =VALDECOXIB 10 MG;
VALDECOXIB 20 MG |
- 29. 1-Methyl-3-nitro-1-nitrosoguanidine
- [radiomimetic, DNA strand breaking agent used as a "direct acting" experimental carcinogen. ( CSP )] (UMLS (NCI) C0025800) =Organic Chemical; Hazardous or Poisonous Substance ;
=antimetabolite;
Cancer Causing Agents;
nitrosoguanidine;
| - 79. 4-(6-Methoxy-2-naphthalenyl)-2-butanone
- [A naphthylalkanone and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activity. Nabumetone is a prodrug that upon hepatic catalysis converts into the active moiety 6-methoxy-2-naphthylacetic acid (6MNA). 6MNA inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of nabumetone. The formation of thromboxane A2, by thromboxane synthase, is also decreased and results in an inhibition of platelet aggregation. ( NCI )] (UMLS (NCI) C0068334) =Organic Chemical; Pharmacologic Substance ;
=Butanones;
[CN104] NONSTEROIDAL ANTI-INFLAMMATORY ANALGESICS =NABUMETONE 750 MG;
NABUMETONE 500 MG;
|
- 30. 1-methylethyl-2-chloro-5-[[5,6-dihydro-2-methyl- 1, 4-oxathiin-3-yl-carbonyl]-amino]benzoate
- (UMLS (NCI) C0220323) =Organic Chemical; Pharmacologic Substance
| - 80. 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone
- [A yellowish crystalline solid nitrosamine that naturally occurs in tobacco products by oxidation and nitrosation of nicotine during the making and smoking of tobacco. 4-Methylnitrosamino-1,3-pyridyl-1-butanone is only used as a research chemical to induce tumorigenesis. This substance is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0047964) =Organic Chemical; Pharmacologic Substance ;
|
- 31. 10 minutes post challenge
- (UMLS (HL7) C1547062) =Temporal Concept =Time delay post challenge;
| - 81. 4-Methylphenol
- (UMLS (NCI) C0048212) =Organic Chemical ;
|
- 32. 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine
- [A phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium. ( NCI )] (UMLS (NCI) C0040979) =Organic Chemical; Pharmacologic Substance ;
=Phenothiazine;
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS =10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride | - 82. 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide
- [An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome. Imatinib also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF)/c-kit; the SCF/c-kit receptor tyrosine kinase is activated in gastrointestinal stromal tumor (GIST). This agent inhibits proliferation and induces apoptosis in cells that overexpress these oncoproteins. ( NCI )] (UMLS (NCI) C0935989) Imatinib;
IMATINIB PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
Unclassified Ingredients =4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monomethanesulfonate;
IMATINIB 100 MG |
- 33. 10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride
- [A hydrochloride salt form of trifluoperazine, a phenothiazine derivative and a dopamine antagonist with antipsychotic and antiemetic activities. Trifluoperazine exerts its antipsychotic effect by blocking central dopamine receptors, thereby preventing effects such as delusions and hallucinations caused by an excess of dopamine. This agent also functions as a calmodulin inhibitor, thereby leading to elevation of cytosolic calcium. ( NCI )] (UMLS (NCI) C0304381) =Organic Chemical; Pharmacologic Substance =10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine;
=TRIFLUOPERAZINE HYDROCHLORIDE 2 MG/ML;
TRIFLUOPERAZINE HYDROCHLORIDE 1 MG;
TRIFLUOPERAZINE HYDROCHLORIDE 2 MG;
TRIFLUOPERAZINE HYDROCHLORIDE 5 MG;
TRIFLUOPERAZINE HYDROCHLORIDE 10 MG/ML;
TRIFLUOPERAZINE HYDROCHLORIDE 10 MG;
| - 83. 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide Monomethanesulfonate
- [A drug that is being studied for its ability to inhibit the growth of certain cancers. It interferes with a portion of the protein produced by the bcr/abl oncogene. Also called Gleevec and STI571. ( NCI )] (UMLS (NCI) C0939537) Imatinib Mesylate;
IMATINIB MESYLATE PREPARATION =Organic Chemical; Pharmacologic Substance =4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;
Unclassified Ingredients =IMATINIB MESYLATE 100 MG;
IMATINIB MESYLATE 400 MG |
- 34. 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine Hydrochloride
- (UMLS (NCI) C0304371) =Organic Chemical; Pharmacologic Substance =METHDILAZINE;
| - 84. 4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone
- [A substance used for pain relief that is also being studied for its ability to prevent cancer and to block the growth of new blood vessels to solid tumors. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs. ( NCI )] (UMLS (NCI) C0762662) Rofecoxib;
ROFECOXIB PREPARATION;
=Organic Chemical; Pharmacologic Substance =LACTONE;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =ROFECOXIB 50 MG;
ROFECOXIB 12.5 MG/5ML;
ROFECOXIB 25 MG/5ML;
ROFECOXIB 25 MG;
ROFECOXIB 12.5 MG;
|
- 35. 10^3/mcl
- [A derived unit expressed as a number or quantity of objects in billions per unit of volume equal to one liter, or the equivalent in milliliters or microliters. ( NCI )] (UMLS (NCI) C0456615) =Quantitative Concept
| - 85. 5 methoxy N,N dimethyltryptamine
- [major of two hallucinogenic components of Teonanacatl, the sacred mushroom of Mexico, the other component being psilocin. ( CSP )] (UMLS (CSP) C0000588) =Organic Chemical; Biologically Active Substance ;
|
- 36. 15 minutes post challenge
- (UMLS (HL7) C1547064) =Temporal Concept =Time delay post challenge;
| - 86. 5 methoxytryptamine
- [compounds that contain the biogenic monoamine tryptamine and are substituted with one methoxy group and two methyl groups; members of this group include several potent serotonergic hallucinogens found in several unrelated plants, skins of certain toads, and in mammalian brains; they are possibly involved in the etiology of schizophrenia. ( CSP )] (UMLS (CSP) C0000589) =Organic Chemical; Pharmacologic Substance
|
- 37. 17m
- [Mandibular left third molar mesial hemisection ( HL7V3.0 )] (UMLS (HL7) C1552103) =Body Part, Organ, or Organ Component =Permanent dentition;
| - 87. 5 methylcytosine
- [a methylated nucleotide base found in eukaryotic DNA. ( CSP )] (UMLS (CSP) C0049308) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =cytosine analog;
|
- 38. 18m
- [Mandibular left second molar mesial hemisection ( HL7V3.0 )] (UMLS (HL7) C1552105) =Body Part, Organ, or Organ Component =Permanent dentition;
| - 88. 5 minutes post challenge
- (UMLS (HL7) C1547082) =Temporal Concept =Time delay post challenge;
|
- 39. 19m
- [Mandibular left first molar mesial hemisection ( HL7V3.0 )] (UMLS (HL7) C1552107) =Body Part, Organ, or Organ Component =Permanent dentition;
| - 89. 5,10 methylenetetrahydrofolate
- [A folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity. ( NCI )] (UMLS (CSP) C0048858) =Organic Chemical; Pharmacologic Substance; Vitamin =folacin;
|
- 40. 2 minutes post challenge
- (UMLS (HL7) C1547074) =Temporal Concept =Time delay post challenge;
| - 90. 5,10-Methylenetetrahydrofolate Reductase (NADPH) Gene
- [This gene is involved in folate metabolism and methionine biosynthesis. ( NCI )] (UMLS (NCI) C0919427) MTHFR;
MTHFR Gene =Gene or Genome ;
|
- 41. 2 months (60 days) post challenge
- (UMLS (HL7) C1547073) =Temporal Concept =Time delay post challenge;
| - 91. 5-MeC
- [A crystalline, carcinogenic aromatic hydrocarbon consisting of four fused rings and produced by the incomplete combustion of organic matter. 5-Methylchrysene is primarily found in gasoline exhaust and tobacco smoke. 5-Methylchrysene is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0049304) =Organic Chemical; Hazardous or Poisonous Substance
|
- 42. 2,2'-Methylenebis(3,4,6-trichlorophenol)
- [A chlorinated bisphenol antiseptic agent with bacteriostatic activity. Hexachlorophene is used topically in soaps, creams and dermatological preparations and is active against gram-positive organisms, but much less effective against gram-negative organisms. (NCI05) ( NCI )] (UMLS (NCI) C0019435) =Organic Chemical; Pharmacologic Substance ;
=Chlorophenols;
[DE400] SOAPS/SHAMPOOS/SOAP-FREE CLEANSERS =HEXACHLOROPHENE 450 MG;
HEXACHLOROPHENE 480 MG;
HEXACHLOROPHENE 3 %;
HEXACHLOROPHENE 0.25 %;
HEXACHLOROPHENE 1 %;
HEXACHLOROPHENE 5 MG;
| - 92. 5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
- [substituted benzimidazole used as a gastric acid secretion inhibitor. ( CSP )] (UMLS (NCI) C0028978) =Organic Chemical; Pharmacologic Substance ;
=[GA300] ANTIULCER AGENTS;
benzimidazole;
gastric juice inhibitor;
[GA303] H.PYLORI AGENTS;
[GA900] GASTRIC MEDICATIONS, OTHER;
=LANSOPRAZOLE;
OMEPRAZOLE 10 MG;
OMEPRAZOLE 20 MG;
OMEPRAZOLE 40 MG;
|
- 43. 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, Hydrochloride, (2R,6R,11R)-rel-
- [The hydrochloride salt form of pentazocine, a benzomorphan narcotic agonist-antagonist. Pentazocine hydrochloride binds to and activates kappa- and sigma-opioid receptors, resulting in sedation and analgesia. In addition, this agent antagonizes the mu-receptor. Pentazocine hydrochloride partially reverses opiate-induced cardiovascular, respiratory, and behavioral depression. ( NCI )] (UMLS (NCI) C0355587) =Organic Chemical; Pharmacologic Substance =PENTAZOCINE;
=PENTAZOCINE HYDROCHLORIDE 50 MG;
PENTAZOCINE HYDROCHLORIDE 12.5 MG;
PENTAZOCINE HYDROCHLORIDE 25 MG | - 93. 5-Methoxy-N-acetyltryptamine
- [5-methoxy-N-acetyltryptamine, a pineal hormone involved in modulation of skin pigmentation, gonad development, and circadian rhythms. ( CSP )] (UMLS (NCI) C0025219) =Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine; Hormone =neurohormone;
Unclassified Ingredients;
Unclassified Ingredient Preparations;
=MELATONIN CAP/TAB |
- 44. 2-(1-Methylethyl)-4-pentenamide
- [An allylic compound that acts as a suicide inactivator of CYTOCHROME P450 by covalently binding to its heme moiety or surrounding protein. ( MSH )] (UMLS (NCI) C0002160) =Organic Chemical
| - 94. 5-methyltetrahydrofolate:NADP oxidoreductase
- [A flavoprotein (FAD). [EC 1.5.1.20 created 1978 as EC 1.1.1.171, transferred 1984 to EC 1.5.1.20] (from IUBMB). ( NCI )] (UMLS (NCI) C0066357) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 45. 2-(Methacryloyloxy)ethanol
- [A hydroxyester compound and a resin monomer used in desensitizing dentin. By applying 2-hydroxyethyl methacrylate locally to sensitive teeth, sensitive areas in the teeth get sealed and block the dentinal tubules at the dentin surface from stimuli that cause pain. This prevents excitation of the tooth nerve and relieves pain caused by tooth hypersensitivity. ( NCI )] (UMLS (NCI) C0063127) =Organic Chemical; Biomedical or Dental Material ;
| - 95. 6 minutes post challenge
- (UMLS (HL7) C1547084) =Temporal Concept =Time delay post challenge;
|
- 46. 2-(Methoxycarbonyl)propene
- [A methyl ester of methacrylic acid. Methyl methacrylate is a reactive resin, and the polymerized form is used as cement in dentistry, orthopaedic surgery and ophthalmology. The monomer form of this agent has relaxation effect on smooth muscle systemically, which might be a result of nitric oxide-mediated response. ( NCI )] (UMLS (NCI) C0066409) =Organic Chemical; Biomedical or Dental Material ;
=Methylmethacrylates;
[XX000] MISCELLANEOUS AGENTS;
Inactive Ingredient Preparations;
=METHYL METHACRYLATE 100 % | - 96. 6-(methylmercapto)purine ribonucleoside
- [A purine derivative with antineoplastic and anti-angiogenic properties. 6-methylmercaptopurine riboside (6-MMPR) inhibits amidophosphoribosyltransferase, the first committed step in de novo purine synthesis, and inhibits fibroblast growth factor-2 (FGF2)-induced cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0025828) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 47. 2-Mercaptoethanesulfonate, Sodium Salt
- [A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide. ( NCI )] (UMLS (NCI) C0000294) =Organic Chemical; Pharmacologic Substance ;
| - 97. 6-Mercaptopurine Monohydrate
- (UMLS (NCI) C0886849) Purine-6-thiol Monohydrate;
Purine-6-thiol, monohydrate =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 48. 2-Mercaptopyridine 1-oxide Zinc Salt
- [An organometallic compound and a derivative of the naturally occurring antibiotic aspergillic acid with antimicrobial, antifungal and anti-seborrheic effects. Although the mechanism of action has not been fully elucidated, pyrithione zinc maybe entering the cell in its chelate from, dissociating in the cytoplasm and exerting its anti-proliferative effect possibly through interaction with DNA. Alternatively, pyrithione might act by chelating metal cofactors of enzymes through its sulfhydryl group. Pyrithione has also been shown to interfere with thymidine uptake and may act as an antimetabolite for nicotinic acid or vitamin B6. Finally, pyrithione may act as a general transport inhibitor through weak-acid-induced cytosolic acidification and hence partial dissipation of the transmembrane proton motive force (PMF) on which the transport of many organic and inorganic solutes is reliant. ( NCI )] (UMLS (NCI) C0078792) =Organic Chemical; Pharmacologic Substance ;
=Organometallic Compound;
pyridine;
Pyrithione;
Unclassified Ingredient Preparations =PYRITHIONE ZINC 2 %;
PYRITHIONE ZINC 1 %;
PYRITHIONE ZINC 2 %;
PYRITHIONE ZINC 1 %;
| - 98. 6-Mercaptopurine ribonucleoside
- [A sulfhydryl analog of inosine and an antimetabolite with potential antineoplastic and immunosuppressive properties. Thioinosine interferes with de novo purine synthesis and perturbs the pool of nucleotides necessary for DNA replication. As a result, this agent inhibits DNA synthesis, blocks cellular proliferation and induces apoptosis. ( NCI )] (UMLS (NCI) C0039904) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 49. 2-Methoxy-5-Methylaniline
- [A white, crystalline aromatic amine that is soluble in organic solvents and emits toxic fumes of nitrogen oxides when heated to decomposition. p-Cresidine is exclusively used as a chemical intermediate in the manufacture of dyes. p-Cresidine is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05) ( NCI )] (UMLS (NCI) C0056481) =Organic Chemical; Pharmacologic Substance ;
| - 99. 6-Methoxy-7,4'-dihydroxyisoflavone
- (UMLS (NCI) C0253391) =Organic Chemical ;
|
- 50. 2-Methyl-1,3-butadiene
- [An unsaturated pentahydrocarbon, Isoprene is found in certain plants or obtained by distillation of caoutchouc or gutta-percha. In plants, it is elementary in the formation of isoprenoids, fat-soluble vitamins, carotenoids and related pigments. Isoprenes contribute to flavors and fragrances of essential oils and other plant-derived substances. (NCI04) ( NCI )] (UMLS (NCI) C0064044) =Organic Chemical
| - 100. 6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid
- [6-methoxy-alpha-methyl-2-naphthaleneacetic acid; nonsteroidal antiinflammatory drug (NSAID); acts by inhibiting cyclooxygenase and thus prostaglandin synthesis; tocolytic oxytocin antagonist. ( CSP )] (UMLS (NCI) C0027396) =Organic Chemical; Pharmacologic Substance =NSAIDs;
[CN850] ANTIPYRETICS;
Naphthaleneacetic Acids;
naphthalene;
antiarthritic agent;
oxidoreductase inhibitor;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
[CN104] NONSTEROIDAL ANTI-INFLAMMATORY ANALGESICS =NAPROXEN SODIUM;
NAPROXEN 250 MG;
NAPROXEN 375 MG;
NAPROXEN 500 MG;
NAPROXEN 125 MG/5ML;
|
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