DNA Directed RNA Polymerase II Polypeptide A

[Encoded by human POLR2A Gene (RNA Polymerase Beta Prime Chain Family), nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A is the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair. ( NCI )]

UMLS (NCI) C1333229

DNA-Directed RNA Polymerase II Largest Subunit
hRPB220
hsRPB1
POLR2
POLR2A
POLRA
Polymerase (RNA) II (DNA Directed) Polypeptide A (220kD)
Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa
RNA Polymerase II 220 kD Subunit
RPB1
RPBh1
RpIILS
RPO2
RPOL2

Amino Acid, Peptide, or Protein
Enzyme

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