- 101. 2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-
- [A benzothiazolylpiperazine derivative and an atypical antipsychotic agent with an antischizophrenic property. Ziprasidone functions as an antagonist at the dopamine D2 and serotonin 5-HT2A and 5-HT1D receptors, and as an agonist at the 5-HT1A receptor. Ziprasidone also inhibits the synaptic reuptake of serotonin and norepinephrine. The mechanism of action by which ziprasidone exerts its antischizophrenic effect is unknown but is potentially mediated through a combination of dopamine D2 and serotonin 5-HT2 antagonism. This agent also has antagonistic activity against histamine H1 and alpha-1-adrenergic receptors. ( NCI )] (UMLS (NCI) C0380393) =Organic Chemical; Pharmacologic Substance ;
=Piperazines;
thiazole;
[CN709] ANTIPSYCHOTICS, OTHER;
=ZIPRASIDONE 20 MG;
ZIPRASIDONE 40 MG;
ZIPRASIDONE 60 MG;
ZIPRASIDONE 80 MG | - 151. 5-HT-3
- [Serotonin 5-HT-3 Receptor, encoded by the human HTR3 gene, is one of the several different receptors for serotonin (5-hydroxytryptamine, 5-HT), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Whereas all other known serotonin receptor subtypes are G protein-coupled receptors, this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Two isoforms, 1/5-HT3R-AS and 2/5-HT3R-AL, are produced by alternative splicing. (From OMIM, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0295352) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 102. 2H-pyran-2-one,5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11,-tridecatetraenyl)-,trans
- [An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04) ( NCI )] (UMLS (NCI) C0118175) =Organic Chemical; Pharmacologic Substance
| - 152. 5-Hydroxy-6-methyl-3,4-pyridinedimethanol Hydrochloride
- [The hydrochloride salt form of pyridoxine, a water-soluble vitamin B. Pyridoxine hydrochloride is converted into the active form, pyridoxal 5'-phosphate (PLP), an essential cofactor in many enzymatic activities including synthesis of amino acids, neurotransmitters, and sphingolipids. This vitamin is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels. ( NCI )] (UMLS (NCI) C0700496) =Organic Chemical; Pharmacologic Substance; Vitamin =[VT104] PYRIDOXINE;
=PYRIDOXINE HCL 0.3 MG;
MERITENE POWDER (CHOCOLATE);
MERITENE POWDER (MILK CHOCOLATE);
MERITENE POWDER More… |
- 103. 2T- hours
- (UMLS (HL7) C1547059) =Temporal Concept =Duration categories;
| - 153. 5-Hydroxytryptamine (Serotonin) Receptor 2A Gene
- [This gene plays a role in G protein-coupled receptor signal transduction and sterol metabolism. ( NCI )] (UMLS (NCI) C1415809) HTR2A;
HTR2A Gene =Gene or Genome |
- 104. 3 hours post challenge
- (UMLS (HL7) C1547076) =Temporal Concept =Time delay post challenge;
| - 154. 5-Hydroxytryptamine (Serotonin) Receptor 3A Gene
- [This gene plays a role in neurotransmitter modulation and in chaperone activity. ( NCI )] (UMLS (NCI) C1333933) HTR3A;
HTR3A Gene =Gene or Genome ;
|
- 105. 3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-
- [A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery. ( NCI )] (UMLS (NCI) C0056855) =Steroid; Pharmacologic Substance
| - 155. 5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic Acid, 2-Amino-7-(1-methylethyl)-5-oxo-
- [An anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers. ( NCI )] (UMLS (NCI) C0103049) =Organic Chemical; Pharmacologic Substance =aminopyridine;
[OR900] DENTAL AND ORAL AGENTS, TOPICAL OTHER =AMLEXANOX 5 %;
|
- 106. 3-(3-Hydroxyanthraniloyl)alanine
- (UMLS (NCI) C0047472) =Organic Chemical; Pharmacologic Substance ;
| - 156. 5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-
- [A long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratadine is used to provide symptomatic relieve of allergic symptoms. ( NCI )] (UMLS (NCI) C0908935) Desloratadine;
DESLORATADINE PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[AH900] ANTIHISTAMINES, OTHER;
Unclassified Ingredients =DESLORATADINE 5 MG;
|
- 107. 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called signal transduction inhibitors. ( NCI )] (UMLS (NCI) C1134444) NV-06;
Phenoxodiol;
=Organic Chemical; Pharmacologic Substance | - 157. 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-, Maleate(1:1)
- [The maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property. Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. ( NCI )] (UMLS (NCI) C0242523) =Organic Chemical; Pharmacologic Substance =TRIMIPRAMINE;
=TRIMIPRAMINE MALEATE 100 MG;
TRIMIPRAMINE MALEATE 25 MG;
TRIMIPRAMINE MALEATE 50 MG |
- 108. 3-(Hydroxynitrosoamino)-L-alanine
- [An amino acid analog derived from Streptomyces alanosinicus, a purine antagonist, and an adenylosuccinate synthase inhibitor with antineoplastic properties. L-alanosine deprives MTAP-deficient (salvage pathway) tumor cells of de novo synthesized adenosine and is probably responsible for diminished DNA synthesis. The clinical use of L-alanosine may be narrow due to its toxicity profile. (NCI04) ( NCI )] (UMLS (NCI) C0051066) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
| - 158. 5H-Dibenz(b,f)azepine-5-carboxamide
- [anticonvulsant and antineuralgic used in the treatment of pain associated with trigeminal neuralgia and in epilepsy manifested by tonic-clonic and partial seizures. ( CSP )] (UMLS (NCI) C0006949) =Organic Chemical; Pharmacologic Substance =[CN100] ANALGESICS;
[CN400] ANTICONVULSANTS;
azepine;
Dibenzazepines =10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;
CARBAMAZEPINE 100 MG;
CARBAMAZEPINE 100 MG/5ML;
CARBAMAZEPINE 200 MG;
CARBAMAZEPINE 300 MG;
CARBAMAZEPINE 400 MG;
|
- 109. 3-Heptanol, 6-(dimethylamino)-4,4-diphenyl-, Acetate (Ester), (3S,6S)-(-)-
- [The hydrochloride salt form of levomethadyl acetate, a synthetic mu-receptor agonist with analgesic activity. Levomethadyl acetate hydrochloride mimics the actions of endogenous peptides at CNS opioid receptors, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Levomethadyl acetate hydrochloride has less severe withdrawal symptoms compared to the morphine-like agents. In addition, with chronic use, levomethadyl acetate hydrochloride produces cross-tolerance to the effects of other mu-receptor agonists, thereby decreasing the physical dependence. ( NCI )] (UMLS (NCI) C0282232) =Organic Chemical; Pharmacologic Substance ;
=LEVOMETHADYL;
=LEVOMETHADYL ACETATE HYDROCHLORIDE 10 MG/ML | - 159. 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, Hydrochloride
- [The hydrochloride salt form of protriptyline, a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. Protriptyline does not block dopamine transport but may have an indirect dopamine-facilitating effect through interactions of increased peri-synaptic abundance of norepinephrine, particularly in the cerebral cortex, where adrenergic terminals exceed dopaminergic terminals. This results in elevation of mood and behavioral activity. In addition, this agent exhibits anticholinergic activity. ( NCI )] (UMLS (NCI) C0700557) =Organic Chemical; Pharmacologic Substance ;
=PROTRIPTYLINE;
=PROTRIPTYLINE HYDROCHLORIDE 10 MG;
PROTRIPTYLINE HYDROCHLORIDE 5 MG;
|
- 110. 3-Hydroxy-2-phenyl-4H-1-benzopyran-4-one
- (UMLS (NCI) C0284815) =Organic Chemical; Pharmacologic Substance
| - 160. 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione,1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)
- [An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics. ( NCI )] (UMLS (NCI) C0073012) =Organic Chemical; Antibiotic ;
|
- 111. 3-hydroxy-3-methylglutaryl-Coenzyme A Reductase
- [Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis. ( MSH )] (UMLS (NCI) C0063164) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 161. 5HT transporter
- [responsible for accumulation of serotonin in peripheral blood cells, placenta, and lungs. ( CSP )] (UMLS (CSP) C0170657) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=membrane transport protein;
|
- 112. 3-Hydroxy-5-methoxy-6-methyl-2-pentyl-4H-pyran-4-one
- (UMLS (NCI) C0647702) =Organic Chemical; Pharmacologic Substance
| - 162. 6 hours
- (UMLS (HL7) C1292428) =Temporal Concept ;
=Duration categories;
|
- 113. 3-Hydroxy-alpha-methyl-L-tyrosine
- [A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure. ( NCI )] (UMLS (NCI) C0025741) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine =dihydroxyphenylalanine;
[CV490] ANTIHYPERTENSIVES, OTHER =(-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic Acid;
METHYLDOPATE;
METHYLDOPA 250 MG;
METHYLDOPA 125 MG;
METHYLDOPA 500 MG | - 163. 6 hours post challenge
- (UMLS (HL7) C1547083) =Temporal Concept =Time delay post challenge;
|
- 114. 3-Hydroxyestra-1,3,5(10),7-tetraen-17-one
- [A naturally occurring steroid with estrogenic activity obtained from the urine of pregnant mares. ( NCI )] (UMLS (NCI) C0014654) =Steroid; Pharmacologic Substance; Hormone
| - 164. 6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone Hydrochloride
- [The hydrochloride salt form of raloxifene, a selective benzothiophene estrogen receptor modulator (SERM) with lipid lowering effects and activity against osteoporosis. Raloxifene hydrochloride specifically binds to estrogen receptors in responsive tissue, including liver, bone, breast, and endometrium. The resulting ligand-receptor complex is translocated to the nucleus where, depending on the tissue type, it promotes or suppresses the transcription of estrogen-regulated genes, thereby exerting its agonistic or antagonistic effects. This agent functions as an estrogen agonist in lipid metabolism, thereby decreasing total and LDL cholesterol levels. In tissue like bone, it decreases bone resorption and bone turnover and increases bone mineral density. Raloxifene hydrochloride acts as an estrogen antagonist in uterine and breast tissue. This agent also exerts an anti-proliferative effect on estrogen-sensitive breast cancer. ( NCI )] (UMLS (NCI) C0618111) =Organic Chemical; Pharmacologic Substance ;
=[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone;
=RALOXIFENE HYDROCHLORIDE 60 MG |
- 115. 3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione) prop-beta-en-alpha-ol
- [A bioreductive indoloquinone prodrug with potential antineoplastic and radiosensitizing activities. Apaziquone, an analogue of mitomycin C, becomes activated after being reduced by various reductases depending on tissue types. The activated metabolite and the reactive free radicals generated during reduction process cause DNA damages, thereby leading to induction of apoptosis. Furthermore, this agent displays cancer selectivity against both the hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and also against the well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase). ( NCI )] (UMLS (NCI) C0095568) =Organic Chemical; Pharmacologic Substance ;
| - 165. 6H-furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,(2R(2alpha,3beta,3a beta,9a beta))
- [Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action. ( MSH )] (UMLS (NCI) C0010557) =Organic Chemical; Pharmacologic Substance ;
|
- 116. 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-
- [pyrazine with antiviral, schistosomicidal and anticarcinogenic properties. ( CSP )] (UMLS (NCI) C0069456) =Organic Chemical; Pharmacologic Substance ;
=thione;
| - 166. 6H-Purine-6-thione, 2-amino-9-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-1,9-dihydro- (9CI)
- [A purine analog with potential antineoplastic activity. (NCI04) ( NCI )] (UMLS (NCI) C0051299) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 117. 3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl, 4-oxide
- [anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties; also used in the symptomatic treatment of alcohol withdrawal. ( CSP )] (UMLS (NCI) C0008188) =Organic Chemical; Pharmacologic Substance ;
=benzodiazepine;
tranquilizer;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS;
=CHLORDIAZEPOXIDE HYDROCHLORIDE;
CHLORDIAZEPOXIDE 10 MG;
CHLORDIAZEPOXIDE 5 MG;
| - 167. 6H-Pyrido[4, 3-b]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)
- [A derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis (NCI04) ( NCI )] (UMLS (NCI) C0100593) =Organic Chemical; Pharmacologic Substance ;
|
- 118. 4 hours
- (UMLS (HL7) C1292426) =Temporal Concept ;
=Duration categories;
| - 168. 7 hours post challenge
- (UMLS (HL7) C1547086) =Temporal Concept =Time delay post challenge;
|
- 119. 4 hours post challenge
- (UMLS (HL7) C1547079) =Temporal Concept =Time delay post challenge;
| - 169. 7H-benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methyl
- [An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. ( NCI )] (UMLS (NCI) C0217476) =Organic Chemical; Pharmacologic Substance ;
|
- 120. 4 hydroxynonenal
- [ ] (UMLS (CSP) C0048297) =Organic Chemical; Pharmacologic Substance
| - 170. 8 hours
- (UMLS (HL7) C1292429) =Temporal Concept ;
=Duration categories;
|
- 121. 4 hydroxyphenylpyruvate dioxygenase
- [An enzyme that catalyzes the conversion of 4-hydroxyphenylpyruvate plus oxygen to homogentisic acid and carbon dioxide. EC 1.13.11.27. ( MSH )] (UMLS (CSP) C0000507) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 171. 8 hours aligned on nursing shifts
- (UMLS (HL7) C1547089) =Temporal Concept =Time delay post challenge;
|
- 122. 4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-met-hylethyl)phenol) S,S-dioxide
- [A dye used as an indicator in determining pH. Bromthymol blue is a weak acid. It can be in acid or base form, depending on the pH of the solution. This reagent is yellow in acidic solutions, blue in basic solutions and green in neutral solution. ( NCI )] (UMLS (NCI) C0006251) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid
| - 172. 8 hours post challenge
- (UMLS (HL7) C1547088) =Temporal Concept =Time delay post challenge;
|
- 123. 4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-
- [antibiotic substance derived from Penicillium stoloniferum and related species which blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase; mycophenolic acid has selective effects on the immune system, preventing the proliferation of T cells, lymphocytes, and the formation of antibodies from B cells. ( CSP )] (UMLS (NCI) C0026933) =Lipid; Antibiotic =antineoplastic antibiotics;
benzofuran;
Caproates;
=RS 61443 | - 173. 9H-Purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI)
- [A toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest. This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0063555) =Organic Chemical; Pharmacologic Substance ;
|
- 124. 4-Hexylresorcinol
- [A substituted phenol with bactericidal, antihelminthic and potential antineoplastic activities. Hexylresorcinol is used as an antiseptic in mouthwashes and skin wound cleansers. Hexylresorcinol may also inhibit oxidative DNA damage by enhancing the activity of antioxidant enzymes, including glutathione peroxidase and glutathione reductase, which facilitate scavenging reactive oxygen molecules by glutathione (GSH). ( NCI )] (UMLS (NCI) C0019497) =Organic Chemical; Pharmacologic Substance
| - 174. 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-
- [A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors. ( NCI )] (UMLS (NCI) C0039955) =Organic Chemical; Pharmacologic Substance =Thioxanthenes;
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS =9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, Dihydrochloride, Dihydrate |
- 125. 4-HYDROXY BUTYRIC ACID
- [A naturally occurring short-chain fatty acid, and immediate precursor of gamma amino butyric acid (GABA) with neuromodulatory and anesthetic properties. Gamma-Hydroxybutyric Acid (GHB) is found in all human tissues, with the highest concentration in the brain. This agent stimulates the GHB receptor, and to a lesser extent GABA-B receptors. Although, the precise function and metabolic pathways of GHB are not fully understood, this agent easily crosses the blood-brain barrier, and affects the activities and levels of dopamine, acetylcholine, dynorphin and serotonin. The primary effect of GHB is central nervous system depression, thereby, its main usage is to induce anesthesia. ( NCI )] (UMLS (NCI) C0673093) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
| - 175. 9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, Dihydrochloride, Dihydrate
- [The hydrochloride salt form of thiothixene, a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors. ( NCI )] (UMLS (NCI) C0304386) =Organic Chemical; Pharmacologic Substance =9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-;
=THIOTHIXENE HYDROCHLORIDE 1 MG;
THIOTHIXENE HYDROCHLORIDE 5 MG;
THIOTHIXENE HYDROCHLORIDE 10 MG;
THIOTHIXENE HYDROCHLORIDE 20 MG;
THIOTHIXENE HYDROCHLORIDE 5 MG/ML;
THIOTHIXENE HYDROCHLORIDE 2 MG/ML;
THIOTHIXENE HYDROCHLORIDE 2 MG |
- 126. 4-Hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
- [An oxicam derivative and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, antipyretic and analgesic activities. Unlike traditional nonselective NSAIDs, meloxicam preferentially inhibits the activity of cyclo-oxygenase II (COX-II), resulting in a decreased conversion of arachidonic acid into prostaglandin precursors. The resulting decrease in prostaglandin synthesis is responsible for the therapeutic effects of meloxicam. ( NCI )] (UMLS (NCI) C0083381) =Organic Chemical; Pharmacologic Substance =thiazine;
thiazole;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
=MELOXICAM 7.5 MG;
MELOXICAM 15 MG;
| - 176. H
- [Maxillary left primary canine ( HL7V3.0 )] (UMLS (HL7) C0227092) =Body Part, Organ, or Organ Component =Primary dentition;
|
- 127. 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxide
- [4-hydroxy-2-methyl-N-2-pyridyl-2H-1,2- benzothiazine-3-carboxamide- 1,1-dioxide; nonsteroidal antiinflammatory drug (NSAID) which functions by inhibiting prostaglandin synthesis; effective against colon cancer. ( CSP )] (UMLS (NCI) C0031990) =Organic Chemical; Pharmacologic Substance ;
=antiinflammatory agent;
[AN000] ANTINEOPLASTICS;
thiazine;
antiarthritic agent;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC;
=PIROXICAM 10 MG;
PIROXICAM 20 MG;
| - 177. h
- [A unit measure of time equal to 3,600 seconds or 60 minutes. It is approximately 1/24 of a median day. (NCI) ( NCI )] (UMLS (NCI) C0439227) =Temporal Concept =Precision;
UnitOfMeasureAtomInsens;
UnitOfMeasureAtomSens;
|
- 128. 4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one
- [An alkaloid isolated from the root of Sinomenium acutum with immunomodulatory and potential anti-angiogenic and activities. Although the mechanism of action remains to be fully elucidated, sinomenine appears to inhibit endothelial proliferation mediated through basic fibroblast growth factor (bFGF), which may contribute to its anti-angiogenic effect. In Chinese medicine, this agent has a long track-record in treating arthritis, which is accounted by its ability to inhibit proliferation of synovial fibroblasts and lymphocytes. In addition, sinomenine has been shown to suppress expressions of genes involved in inflammation and apoptosis, such as interleukin-6, a pleiotropic inflammatory cytokine and JAK3 (Janus kinase 3), Daxx (death-associated protein 6), plus HSP27 (heat shock 27kDa protein 1), respectively. ( NCI )] (UMLS (NCI) C0074568) =Organic Chemical; Pharmacologic Substance ;
| - 178. H
- [The SI derived unit of electric inductance. A coil with an inductance of one henry requires a flux of one weber for each ampere of induced current. If it is the current which changes, then the induced field will generate a potential difference within the coil: if the inductance is one henry a current change of one ampere per second generates a potential difference of one volt. The henry is a large unit; inductances in practical circuits are measured in millihenrys or microhenrys. ( NCI )] (UMLS (NCI) C0582517) =Quantitative Concept ;
=UnitOfMeasureAtomInsens;
|
- 129. 4-Hydroxyacetanilide
- [analgesic antipyretic derivative of acetanilide; weak antiinflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage. ( CSP )] (UMLS (NCI) C0000970) =Organic Chemical; Pharmacologic Substance ;
| - 179. H and N
- [For oncology, an area of the body generally construed to comprise the base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas. ( NCI )] (UMLS (NCI) C0460004) =Body Location or Region
|
- 130. 4-Hydroxyandrost-4-ene-3,17-dione
- [A synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04) ( NCI )] (UMLS (NCI) C0048306) =Organic Chemical; Pharmacologic Substance
| - 180. H antigen
- [ ] (UMLS (CSP) C0062044) =Amino Acid, Peptide, or Protein; Immunologic Factor
|
- 131. 4-hydroxyanisole
- [A synthetic derivate of hydroquinone and depigmenting agent. Although the exact mechanism of the depigmenting effects of mequinol remains unclear, it may exert its effect by oxidation of tyrosinase to cytotoxic products in melanocytes. Mequinol may also act by competitively inhibiting the formation of melanin precursors. ( NCI )] (UMLS (NCI) C0048318) =Organic Chemical; Pharmacologic Substance
| - 181. H element
- [first chemical element in the periodic table; atomic symbol H, atomic number 1; it exists, under normal conditions, as a colorless, odorless, tasteless, diatomic gas; hydrogen ions are protons. ( CSP )] (UMLS (CSP) C0020275) =Element, Ion, or Isotope =Element;
=deuterium;
H3 radionuclide;
|
- 132. 4-Hydroxytamoxifen
- [A tamoxifen metabolite with both estrogenic and anti-estrogenic effects. 4-hydroxytamoxifen has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells. (NCI04) ( NCI )] (UMLS (NCI) C0048403) =Organic Chemical; Pharmacologic Substance
| - 182. H SIMPLEX COMPLICAT NEC
- [ ] (UMLS (ICD9CM) C0153043) =Disease or Syndrome
|
- 133. 4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol Hydrochloride
- [The hydrochloride salt form of isoproterenol, a synthetic catechol compound and potent beta adrenergic agonist with peripheral vasodilator, bronchodilator, and cardiac stimulating properties. Isoproterenol exerts its effect on the beta1-receptors in the myocardium, thereby increasing heart rate and cardiac output. In addition, isoproterenol acts on beta2-receptors in bronchiolar and vascular smooth muscle, thereby causing smooth muscle relaxation. ( NCI )] (UMLS (NCI) C0282210) =Organic Chemical; Pharmacologic Substance =isoprenaline;
=ISOPROTERENOL HYDROCHLORIDE 0.2 MG/ML;
| - 183. H SIMPLEX COMPLICAT NOS
- (UMLS (ICD9CM) C0153047) =Disease or Syndrome
|
- 134. 4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt
- [An anticancer drug that belongs to the family of drugs called alkyl phospholipids. ( NCI )] (UMLS (NCI) C0754570) Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphate;
Octadecylphosphopiperidine;
PERIFOSINE;
=Organophosphorus Compound; Pharmacologic Substance | - 184. H SIMPLEX IRIDOCYCLITIS
- [ ] (UMLS (ICD9CM) C0153039) =Disease or Syndrome
|
- 135. 4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-methoxy-
- (UMLS (NCI) C0072562) =Organic Chemical
| - 185. H SIMPLEX KERATITIS
- [ ] (UMLS (ICD9CM) C0153038) =Disease or Syndrome
|
- 136. 4H-1-benzopyran-8-acetic Acid, 4-Oxo-2-phenyl
- [A synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits an antiproliferative effect on endothelial cells as a result of a superoxide-dependent mechanism, which induces changes in permeability of the vasculature of the tumor. This agent may stimulate tumor necrosis and promote shunting of blood flow to viable regions of the tumor, increasing their oxygenation and rendering them more susceptible to the antitumor effects of hyperthermia and ionizing radiation. (NCI04) ( NCI )] (UMLS (NCI) C0060441) =Organic Chemical; Pharmacologic Substance
| - 186. H SIMPLEX MENINGITIS
- (UMLS (ICD9CM) C0153045) =Disease or Syndrome
|
- 137. 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-Tetrahydro-6-methyl-, Hydrochloride,(6aR)-
- [The hydrochloride salt form of apomorphine, a derivative of morphine and non-ergoline dopamine agonist with high selectivity for dopamine D2, D3, D4 and D5 receptors. Apomorphine hydrochloride acts by stimulating dopamine receptors in the nigrostriatal system, hypothalamus, limbic system, pituitary gland, and blood vessels. This enhances motor function, suppresses prolactin release, and causes vasodilation and behavioral effects. Apomorphine hydrochloride is used in the treatment of Parkinson's disease and erectile dysfunction. In addition, apomorphine hydrochloride acts on the chemoreceptor trigger zone and is used as a central emetic in the treatment of drug overdose. ( NCI )] (UMLS (NCI) C0237406) =Organic Chemical; Pharmacologic Substance =apomorphine;
TO BE DELETED INGREDIENT PREPARATIONS =APOMORPHINE HYDROCHLORIDE 6 MG;
| - 187. H SIMPLEX OTITIS EXTERNA
- (UMLS (ICD9CM) C0153046) =Disease or Syndrome
|
- 138. 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic Acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, Ethyl Ester
- [An imidazo-benzodiazepine derivative, effective in reversing benzodiazepine-induced activities. Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. ( NCI )] (UMLS (NCI) C0016293) =Organic Chemical; Pharmacologic Substance ;
=Benzodiazepinones;
[AD900] ANTIDOTES/DETERRENTS, OTHER =FLUMAZENIL 0.1 MG/ML | - 188. H ZOSTER COMPLICATED NEC
- [ ] (UMLS (ICD9CM) C0153030) =Disease or Syndrome
|
- 139. 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-, Monohydrochloride
- [The hydrochloride salt form of molindone, a dihydroindolone compound with antipsychotic and anti-schizophrenic properties not structurally related to other major tranquilizers. Molindone hydrochloride exerts its effect by blocking dopamine receptors, probably D2 and D3, in the reticular activating and limbic systems, thereby decreasing dopamine excess in the brain. This leads to a reduction of spontaneous locomotion and aggressiveness, suppression of conditioned response, antagonism of stereotyped behaviour and hyperactivity induced by amphetamines. ( NCI )] (UMLS (NCI) C0282249) =Organic Chemical; Pharmacologic Substance ;
=MOLINDONE;
=MOLINDONE HYDROCHLORIDE 100 MG;
MOLINDONE HYDROCHLORIDE 20 MG/ML;
MOLINDONE HYDROCHLORIDE 50 MG;
MOLINDONE HYDROCHLORIDE 10 MG;
MOLINDONE HYDROCHLORIDE 25 MG;
MOLINDONE HYDROCHLORIDE 5 MG;
| - 189. H ZOSTER COMPLICATED NOS
- [ ] (UMLS (ICD9CM) C0276249) =Disease or Syndrome
|
- 140. 4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, Dihydrochloride,(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-
- [The hydrochloride salt form of spectinomycin, an aminocyclitol antibiotic derived from Streptomyces spectabilis with antibacterial property. Spectinomycin hydrochloride binds to the bacterial 30S ribosomal subunit, thereby inhibiting peptide elongation and protein synthesis, consequently leading to bacterial cell death. ( NCI )] (UMLS (NCI) C0887525) Spectinomycin Dihydrochloride;
SPECTINOMYCIN HYDROCHLORIDE;
Spectinomycin Hydrochloride Anhydrous;
SPECTINOMYCIN HYDROCHLORIDE PREPARATION;
Spectogard;
=Organic Chemical; Antibiotic ;
=SPECTINOMYCIN;
=SPECTINOMYCIN HYDROCHLORIDE 2 GM/VIL | - 190. H ZOSTER IRIDOCYCLITIS
- [ ] (UMLS (ICD9CM) C0153028) =Disease or Syndrome
|
- 141. 4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Disodium Salt
- [The sodium salt form of nedocromil, a pyranoquinolone derivative with anti-inflammatory properties. Nedocromil sodium inhibits the activation and release of inflammatory mediators (leukotrienes, histamine and prostaglandins) from a variety of cells involved in hypersensitivity reactions, including mast cells, eosinophils, neutrophils, macrophages, monocytes and platelets. As a result, nedocromil sodium inhibits both immediate and late bronchoconstriction, decreases bronchial hyperresponsiveness and inhibits recruitment of other inflammatory cells into the airway epithelium. ( NCI )] (UMLS (NCI) C0886658) FPL 59002KP;
NEDOCROMIL SODIUM;
NEDOCROMIL SODIUM PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=NEDOCROMIL;
=NEDOCROMIL SODIUM 1.75 MG/ACTUAT;
NEDOCROMIL SODIUM 2 %;
| - 191. H ZOSTER KERATOCONJUNCT
- [ ] (UMLS (ICD9CM) C0153027) =Disease or Syndrome
|
- 142. 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-
- [A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis. ( NCI )] (UMLS (NCI) C0032911) =Organic Chemical; Pharmacologic Substance ;
=Anthelminthics;
2 benzazine =PRAZIQUANTEL 600 MG | - 192. H ZOSTER NERV SYST NEC
- [ ] (UMLS (ICD9CM) C0153022) =Disease or Syndrome
|
- 143. 4H-Pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, Potassium Salt
- [The potassium salt form of pemirolast, a pyrimidinone derivative with antiallergic property. Pemirolast potassium exerts its action by blocking the antigen-mediated calcium ion influx into mast cells. This prevents mast cell degranulation, resulting in mast cell stabilization and inhibition of the release of inflammatory mediators, histamine and leukotrienes, which are involved in the allergic process. Pemirolast potassium also prevents inflammatory mediator release from eosinophils. ( NCI )] (UMLS (NCI) C0872971) Pemirolast Potassium;
PEMIROLAST POTASSIUM PREPARATION;
PEMIROLAST POTASSIUM UNIDENTIFIED =Organic Chemical; Pharmacologic Substance ;
=Pemirolast;
Unclassified Ingredients | - 193. H ZOSTER NERV SYST NOS
- [ ] (UMLS (ICD9CM) C1264623) Herpes zoster with unspecified nervous system complication =Disease or Syndrome
|
- 144. 4H-Pyrrolo(3,2-d)pyrimidin-4-one,1,5-dihydro-2-amino-7-(3-pyridinylmethyl)
- [A substance that is being studied for the treatment of cancer. ( NCI )] (UMLS (NCI) C0338278) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 194. H ZOSTER OTITIS EXTERNA
- [ ] (UMLS (ICD9CM) C0153031) =Disease or Syndrome
|
- 145. 5 hours post challenge
- (UMLS (HL7) C1547081) =Temporal Concept =Time delay post challenge;
| - 195. H+ element
- [A small, positively charged particle of matter found in the atoms of all elements. Streams of protons generated by special equipment can be used for radiation treatment. ( NCI )] (UMLS (CSP) C0033727) =Element, Ion, or Isotope ;
=ion;
|
- 146. 5 hydroxytryptamine
- [biochemical messenger and regulator, synthesized from tryptophan; in humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. ( CSP )] (UMLS (CSP) C0036751) =Organic Chemical; Neuroreactive Substance or Biogenic Amine ;
=Neurotransmitter;
tryptamine | - 196. H+ K+ ATPase
- [hydrolysis of ATP is coupled with the exchange of hydrogen and potassium ions. ( CSP )] (UMLS (CSP) C0071766) =Amino Acid, Peptide, or Protein; Enzyme ;
=Adenosine Triphosphatase;
|
- 147. 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic Acid], Disodium Salt
- [The sodium salt form of cromolyn, a mast cell stabilizer with anti-inflammatory activity. Cromolyn sodium probably interferes with the antigen-stimulated calcium transport across the mast cell membrane, thereby inhibiting mast cell release of histamine, leukotrienes, and other substances that cause hypersensitivity reactions. Cromolyn sodium also inhibits eosinophil chemotaxis. ( NCI )] (UMLS (NCI) C0012694) =Organic Chemical; Pharmacologic Substance ;
=Chromones;
cromoglycic acid =CROMOLYN SODIUM 800 MCG/ACTUAT;
CROMOLYN SODIUM 100 MG;
CROMOLYN SODIUM 4 %;
CROMOLYN SODIUM 100 MG/5ML;
CROMOLYN SODIUM 10 MG/ML;
| - 197. H+- transporting ATP synthase
- [two domain protein (F1 and F0) of inner mitochondrial membrane which couples electron transport to ATP synthesis via the proton gradient across the membrane when uncoupled, the reverse (ATPase) reaction drives a proton pump. ( CSP )] (UMLS (CSP) C0018437) =Amino Acid, Peptide, or Protein; Enzyme =Adenosine Triphosphatase;
membrane transport protein;
respiratory enzyme;
|
- 148. 5-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-,(5Z)-
- [A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intracocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors. ( NCI )] (UMLS (NCI) C0937917) Bimatoprost;
BIMATOPROST PREPARATION;
BIMATOPROST UNIDENTIFIED;
=Lipid; Pharmacologic Substance ;
=[OP109] ANTIGLAUCOMA, OTHER;
Unclassified Ingredients =BIMATOPROST 0.03 %;
| - 198. H-2Q1
- [A sub-type of MHC Class I ( NCI )] (UMLS (NCI) C1368327) Qa1;
Qa-1;
Qa-1 Antigen;
Qed-1 =Amino Acid, Peptide, or Protein; Immunologic Factor |
- 149. 5-Heptenoic Acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester,(5Z)-
- [A synthetic lipophilic isopropyl ester prodrug of the active compound travoprost free acid, a prostaglandin F2alpha analog with anti-glaucoma property. Upon administration, travoprost is hydrolysed to a free acid by corneal esterases, and then selectively stimulating the prostaglandin F (FP prostanoid) receptor, thereby increasing the uveoscleral outflow which leads to a reduction in intra-ocular pressure. ( NCI )] (UMLS (NCI) C0937916) Travoprost;
TRAVOPROST PREPARATION;
TRAVOPROST UNIDENTIFIED;
=Organic Chemical; Pharmacologic Substance ;
=[OP109] ANTIGLAUCOMA, OTHER;
Unclassified Ingredients =TRAVOPROST 0.004 %;
| - 199. H-2RIIBP
- [Expressed as 2 alternative isoforms by human RXRB Gene (NR2/RXR Family), nuclear Retinoid X Receptor Beta is a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRB forms homodimers and heterodimers with RA-, TH-, and vitamin D receptors and mediates RA biological effects by binding specific target gene promoter sequences and inducing activation of target gene transcription. RARB/RXRB and RARB/RXRG may regulate locomotion and be functionally redundant. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI) ( NCI )] (UMLS (NCI) C0527031) =Amino Acid, Peptide, or Protein; Receptor
|
- 150. 5-HIAA
- [5HIAA. A breakdown product of serotonin that is excreted in the urine. Serotonin is a hormone found at high levels in many body tissues. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors. ( NCI )] (UMLS (NCI) C0020361) =Organic Chemical; Biologically Active Substance ;
| - 200. h-NEU
- [Expressed in brain by human NEURL Gene, 574-aa 62-kDa Neuralized-like Protein is a homolog of neuralized (neu: Drosophila, C. elegans) that appears to be involved in embryonic neurogenic cell fate determination in the central nervous system. Like neu, NEURL contains 2 NHRs (neuralized homology repeats) and a C-terminal RING finger. (NCI) ( NCI )] (UMLS (NCI) C1334951) Neuralized Homolog;
Neuralized-Like Protein;
NEURL =Amino Acid, Peptide, or Protein; Neuroreactive Substance or Biogenic Amine |
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