- 1. hVDAC1
- [Expressed in heart, liver, and skeletal muscle by human VDAC1 Gene (Mitochondrial Porin Family), ubiquitous 282-aa 31-kDa Voltage-Dependent Anion Channel-1 protein consists mainly of membrane-spanning beta-sheets that form a channel in the mitochondrial outer membrane and plasma membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis; BCLXL binds to and closes VDAC. Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases. (NCI) ( NCI )] (UMLS (NCI) C1259712) Outer Mitochondrial Membrane Protein Porin-1;
Plasmalemmal Porin;
Porin;
Porin 31HL;
Porin 31HM;
VDAC-1;
Voltage-Dependent Anion Channel-1;
Voltage-Dependent Anion-Selective Channel Protein-1;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2. hVDAC3
- [Widely expressed (highest in testis) as 2 alternative isoforms by human VDAC3 Gene (Mitochondrial Porin Family), Voltage-Dependent Anion Channel-3 protein consists mainly of membrane-spanning beta-sheets in the outer mitochondrial membrane forming a channel that allows diffusion of small hydrophilic molecules. (NCI) ( NCI )] (UMLS (NCI) C0902444) Outer Mitochondrial Membrane Protein Porin-3;
Voltage-Dependent Anion Channel-3;
Voltage-Dependent Anion-Selective Channel Protein-3;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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