[An amino acid analog derived from Streptomyces alanosinicus, a purine antagonist, and an adenylosuccinate synthase inhibitor with antineoplastic properties. L-alanosine deprives MTAP-deficient (salvage pathway) tumor cells of de novo synthesized adenosine and is probably responsible for diminished DNA synthesis. The clinical use of L-alanosine may be narrow due to its toxicity profile. (NCI04) ( NCI )]
UMLS (NCI) C0051066 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance