[A cell surface antigen expressed on all tumors of neuroectodermal origin, including melanoma, neuroblastomas, sarcoma, astrocytomas, and small cell lung cancer. GD3 is an O-acetylated disialoganglioside, belongs to the group of glycosphingolipids that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators. GD3 and GD2 gangliosides represent distinct and relevant immunotherapeutic target structures on melanoma, thereby both have potential to be used as components of anti-melanoma vaccines. ( NCI )]
UMLS (NCI) C0061105 - Lipid
- Biologically Active Substance