- 1. (+-)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate
- [The nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation, resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere with the autolytic degradation of fungal DNA and RNA. ( NCI )] (UMLS (NCI) C0144004) =Organic Chemical; Pharmacologic Substance ;
=SULCONAZOLE; =SULCONAZOLE NITRATE 1 % | - 24. dic
- [An abnormal chromosome with two centromeres as opposed to the normal one centromere. ( NCI )] (UMLS (NCI) C0333710) =Cell or Molecular Dysfunction ;
|
- 2. (Dichloromethylene)bisphosphonic Acid
- [A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activity. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption. ( NCI )] (UMLS (NCI) C0012081) =Organophosphorus Compound; Pharmacologic Substance
| - 25. dicarboxylate
- [acid or salt containing two carboxyl (=COOH) groups. ( CSP )] (UMLS (CSP) C0178595) =Organic Chemical =carboxylate;
=glutarate; oxalate; oxaloacetate; succinate; N phosphonoacetyl L aspartate; malate; malonate |
- 3. 1,1'-Dichlorodimethyl Ether
- [A colorless, flammable, carcinogenic liquid with an extremely suffocating odor. Bis(Chloromethyl) Ether is used in industry as an alkylating agent, a chemical intermediate, a monitoring indicator for the presence of chloromethyl ether, and as a laboratory reagent. This substance is irritating to eyes and mucous membranes and emits toxic vapors of hydrochloric acid and other chlorinated compounds when heated to decomposition. Exposure to Bis(Chloromethyl) ether is associated with higher risk of developing lung cancer, mainly small-cell type, and the risk increases with increasing duration and cumulative exposure. (NCI05) ( NCI )] (UMLS (NCI) C0005627) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 26. DICER1
- [This gene is involved in the RNA interference pathway. ( NCI )] (UMLS (NCI) C1333218) DICER1 Gene;
Dicer1, Dcr-1 Homolog (Drosophila) Gene =Gene or Genome ; |
- 4. 1,1-Dichloro-2-chloroethylene
- [toxic liquid widely used as an industrial solvent, formerly used as an inhalation anesthetic. ( CSP )] (UMLS (NCI) C0040905) =Organic Chemical; Pharmacologic Substance =[CN200] ANESTHETICS;
haloalkene | - 27. dichlorethylnitrosourea
- [ ] (UMLS (CSP) C0920458) =Organic Chemical ;
|
- 5. 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
- [A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. (NCI04) ( NCI )] (UMLS (NCI) C0936065) 5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-;
Becatecarin; DEAE-Rebeccamycin; Rebeccamycin analog; Rebeccamycin Analogue; =Organic Chemical; Antibiotic ; | - 28. Dichloride
- [The chloride salt form of succinylcholine, a quaternary ammonium compound and depolarizing agent with short-term muscle relaxant properties. Succinylcholine chloride binds to nicotinic receptors at the neuromuscular junction and opening the ligand-gated channels in the same way as acetylcholine, resulting in depolarization and inhibition of neuromuscular transmission. Depolarization may be prolonged due to succinylcholine's resistance to acetylcholinesterases thereby leading to disorganized muscle contraction followed by skeletal muscle relaxation and flaccid paralysis. ( NCI )] (UMLS (NCI) C0012792) =Organic Chemical; Pharmacologic Substance =SUCCINYLCHOLINE;
=SUCCINYLCHOLINE CHLORIDE 20 MG/ML; SUCCINYLCHOLINE CHLORIDE 50 MG/ML; SUCCINYLCHOLINE CHLORIDE 100 MG/ML |
- 6. 1,2-Dichloroethane
- [A clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0015081) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 29. dichloroacetate
- [derivative of acetic acid which increases the activity of pyruvate dehydrogenase and rate of lipogenesis; it is used in organic synthesis, pharmaceuticals, and medicine. ( CSP )] (UMLS (CSP) C0012066) =Organic Chemical; Pharmacologic Substance =acetate;
=Bichloroacetic Acid; |
- 7. 1,3-Dichloro-1-propene
- [A synthetic, flammable, colorless liquid that is relatively insoluble in water and soluble in ether, acetone, toluene and benzene. It is used as an intermediate in the manufacture of 3,3-dichloro-1-propene and other pesticides. When heated to decomposition, 1,3-dichloropropene produces toxic fumes of hydrochloric acid and other chlorinated compounds. The primary routes of exposure are inhalation of vapors, dermal contact, and ingestion of contaminated foods and drinking water. Acute exposure can cause irritation of the eyes, skin and mucous membranes. Inhale a low concentration of vapors can result in irritation of the respiratory tract and central nervous system depression. Breathing higher vapor concentrations of this substance may cause coughing, breathing difficulties, substernal pain and extreme respiratory distress. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0043918) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 30. Dichloroallyl Lawsone
- [A triazine derivative with antineoplastic activity. Dichloroallyl lawsone inhibits mitochondrial dihydroorotate dehydrogenase (DHOD), an enzyme that catalyzes the only redox step in de novo pyrimidine biosynthesis, and nucleotide (RNA and DNA) biosynthesis. (NCI04) ( NCI )] (UMLS (NCI) C0057845) =Organic Chemical; Pharmacologic Substance ;
|
- 8. 1,4-Dichlor-B
- [A synthetic, white crystalline solid that is practically insoluble in water and soluble in ether, chloroform, carbon disulfide, benzene, alcohol and acetone. It is used primarily as a space deodorant in products such as room deodorizers, urinal and toilet bowl blocks, and as an insecticide fumigant for moth control. When 1,4-dichlorobenzene is heated to decomposition, toxic gases and vapors (such as hydrochloric acid and carbon monoxide) are released. The primary route of potential human exposure to this compound is inhalation. Acute inhalation exposure to 1,4-dichlorobenzene can result in coughing and breathing difficulties. Breathing high levels of this chemical can cause headaches, dizziness and liver damage. Contact with 1,4-dichlorobenzene can irritate the eyes, leading to burning and tearing. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0048243) =Organic Chemical; Hazardous or Poisonous Substance
| - 31. dichlorodimethylvinylphosphate
- [ ] (UMLS (CSP) C0920459) =Organic Chemical; Hazardous or Poisonous Substance
|
- 9. 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
- [An antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections, Miconazole selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes. (NCI04) ( NCI )] (UMLS (NCI) C0025942) =Organic Chemical; Pharmacologic Substance =[AM700] ANTIFUNGALS;
imidazole =1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole Mononitrate; MICONAZOLE 10 MG/ML; Baza Antifungal 20 MG/ML Topical Cream; | - 32. DICHLORPHENAMIDE
- [A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. ( MSH )] (UMLS (NCI) C0012086) =Organic Chemical; Pharmacologic Substance =sulfonamide;
[CV703] CARBONIC ANHYDRASE INHIBITOR DIURETICS =DICHLORPHENAMIDE 50 MG; |
- 10. 1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole Mononitrate
- [The nitrate salt form of miconazole, an antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections, Miconazole selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes. (NCI04) ( NCI )] (UMLS (NCI) C0086620) =Organic Chemical; Pharmacologic Substance ;
=1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; [DE102] ANTIFUNGAL, TOPICAL; [GU300] ANTI-INFECTIVES, VAGINAL; =Miconazole 200 MG Vaginal Suppository; MICONAZOLE NITRATE MISC. POWDER (GM); MICONAZOLE NITRATE 3 X 200 MG; MICONAZOLE NITRATE 200 MG; MICONAZOLE NITRATE 100 MG; MICONAZOLE NITRATE 2 % | - 33. dichroism
- [quality or condition of presenting one color in reflected and another in transmitted light. ( CSP )] (UMLS (CSP) C0596436) =Natural Phenomenon or Process =Optical;
=circular dichroism |
- 11. 2,2'-Dichloro-4,4'-methylenedianiline
- [A tan-colored, solid, chlorinated aromatic amine with an amine-like odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. 4,4-Methylenebis-2-chloroaniline is primarily used in industry as a curing agent for liquid polyurethane elastomers and is used as an experimental carcinogen in research. Exposure to this substance can cause gastrointestinal distress and severe irritation of the face and eyes. 4,4-Methylenebis-2-chloroaniline is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing bladder cancer. (NCI05) ( NCI )] (UMLS (NCI) C0025750) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 34. Diclondazolic Acid
- [An indazole carboxylic acid derivative that exhibits radiosensitizing and antiparasitic effects and interferes with the multidrug resistance mechanism. ( NCI )] (UMLS (NCI) C0065175) =Organic Chemical; Pharmacologic Substance ;
|
- 12. 2,4-Dichloro-1-(4-nitrophenoxy)benzene
- [A white, crystalline, solid, combustible, chlorinated compound. Nitrofen was used as an herbicide, but is no longer used or manufactured in the United States. Exposure to nitrofen irritates the skin, eyes and respiratory tract and affects the blood and central nervous system. This substance is teratogenic and carcinogenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0068833) =Organic Chemical; Hazardous or Poisonous Substance
| - 35. DICOM Class Label
- [From the Message Standards Classes table of the SNOMED-DICOM-Microglossary. College of American Pathologists, Skokie, IL, 60077-1034 ( HL7V3.0 )] (UMLS (HL7) C1552874) =Intellectual Product =CodeSystem;
|
- 13. 2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt
- [The potassium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac potassium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. ( NCI )] (UMLS (NCI) C0282131) =Organic Chemical; Pharmacologic Substance ;
=2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt =DICLOFENAC POTASSIUM 50 MG | - 36. DICOM Controlled Terminology
- (UMLS (HL7) C1550195) =Intellectual Product =Code;
|
- 14. 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid
- [A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04) ( NCI )] (UMLS (NCI) C0012091) =Organic Chemical; Pharmacologic Substance =phenylacetate;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC; [OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC; =2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt; 2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt; | - 37. DICOM modality codes
- [Dean Bidgood, MD; Duke University Medical Center, Durham NC. Digital Imaging and Communications in Medicine (DICOM). From NEMA Publications PS-3.1 - PS 3.12: The ACR-NEMA DICOM Standard. National Electrical Manufacturers Association (NEMA). Rosslyn, VA, ( HL7V3.0 )] (UMLS (HL7) C1556076) =Intellectual Product =CodeSystem;
|
- 15. 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt
- [The sodium salt form of diclofenac, a benzene acetic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Diclofenac sodium is a non-selective reversible and competitive inhibitor of cyclooxygenase (COX), subsequently blocking the conversion of arachidonic acid into prostaglandin precursors. This leads to an inhibition of the formation of prostaglandins that are involved in pain, inflammation and fever. ( NCI )] (UMLS (NCI) C0700583) =Organic Chemical; Pharmacologic Substance =2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid;
=2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt; DICLOFENAC SODIUM 0.1 %; DICLOFENAC SODIUM 50 MG; DICLOFENAC SODIUM 75 MG; DICLOFENAC SODIUM 100 MG; DICLOFENAC SODIUM 25 MG; DICLOFENAC SODIUM 3 % | - 38. DICOM Query Label
- [HL7 Image Management Special Interest Group, Health Level Seven, Ann Arbor, MI. ( HL7V3.0 )] (UMLS (HL7) C1552875) =Intellectual Product =CodeSystem;
|
- 16. 3', 5'-Dichloroamethopterin
- [A chlorinated methotrexate derivative. Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis. This agent is metabolized and excreted by the liver. (NCI04) ( NCI )] (UMLS (NCI) C0046764) =Organic Chemical; Pharmacologic Substance
| - 39. Dictated
- [A completion status in which information has been orally recorded but not yet transcribed. ( HL7V3.0 )] (UMLS (HL7) C1609990) =Idea or Concept ;
=Document completion status; DocumentCompletion |
- 17. 3,3-Dichloro-(1,1-Biphenyl)-4,4-Diamine
- [A synthetic, light-sensitive, gray to purple crystalline solid that is insoluble in cold water but is soluble in ether, benzene, glacial acetic acid and alcohol. It is used primarily in the manufacture of pigments for printing ink, textiles, paper, paint, rubber, and plastics and as a curing agent for isocyanate-containing polymers and solid urethane plastics. When heated to decomposition, 3,3-dichlorobenzidine emits toxic fumes of chlorinated compounds and nitrogen oxides. The primary routes of potential human exposure to 3,3-dichlorobenzidine are inhalation of airborne dust, ingestion of contaminated well water by those living near hazardous waste sites, and dermal contact, primarily during industrial operations. Contact with this compound may cause dermatitis. It is reasonably anticipated to be a human carcinogen. (NCI05) ( NCI )] (UMLS (NCI) C0000370) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 40. dictated
- [Participation by pre-recorded voice. Communication is limited to one direction (from the recorder to recipient). ( HL7V3.0 )] (UMLS (HL7) C1548384) =Intellectual Product ;
=verbal; |
- 18. 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl) pyridine
- [An anticancer drug that belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0070220) =Organic Chemical; Pharmacologic Substance
| - 41. Dictionary
- [A reference book containing a list of words - usually in alphabetical order - giving information about form, pronunciation, etymology, grammar, and meaning. A foreign-language dictionary is an alphabetical list of words of one language with their meaning and equivalents in another language. ( MSH )] (UMLS (NCI) C1101726) =Intellectual Product
|
- 19. 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl Penicillin Sodium Monohydrate
- [The sodium salt form of dicloxacillin, a broad-spectrum, semi-synthetic beta-lactam with bactericidal and beta-lactamase resistant activity. Dicloxacillin sodium binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall. It also inhibits the cross-linkage of peptidoglycan, a critical component of bacterial cell walls. This leads to the inhibition of bacterial cell wall synthesis and eventually causes cell lysis. ( NCI )] (UMLS (NCI) C0887422) DICLOXACILLIN SODIUM;
DICLOXACILLIN SODIUM PREPARATION =Organic Chemical; Antibiotic ; =3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolylpenicillin; =DICLOXACILLIN SODIUM 250 MG; DICLOXACILLIN SODIUM 500 MG; DICLOXACILLIN SODIUM 62.5 MG/5ML | - 42. Dictyostelium
- [genus of protozoa, formerly also considered a fungus; its natural habitat is decaying forest leaves, where it feeds on bacteria; often called cellular slime mold; D. discoideum is the best known species and is widely used in biomedical research. ( CSP )] (UMLS (CSP) C0012120) =Invertebrate ;
=Myxomycophyta; |
- 20. 3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolylpenicillin
- [A broad-spectrum, semi-synthetic, beta-lactam, penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Dicloxacillin binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall. It also inhibits the cross-linkage of peptidoglycan, a critical component of bacterial cell walls. This leads to the inhibition of bacterial cell wall synthesis and eventually causes cell lysis. ( NCI )] (UMLS (NCI) C0012093) =Organic Chemical; Antibiotic =CLOXACILLIN;
[AM053] PENICILLINASE-RESISTANT PENICILLINS =3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl Penicillin Sodium Monohydrate; | - 43. DICYCLOMINE
- [A carboxylic acid derivative and a selective anticholinergic with antispasmodic activity. Dicyclomine blocks acetylcholine from binding to muscarinic receptors on smooth muscle. This agent has a direct relaxing effect on smooth muscle and therefore prevents spasms in the muscles of the gastrointestinal tract, inhibits gastrointestinal propulsive motility, decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretion. ( NCI )] (UMLS (NCI) C0012125) =Organic Chemical; Pharmacologic Substance =Cyclohexanecarboxylic Acids;
parasympatholytic agent =DICYCLOMINE HYDROCHLORIDE; |
- 21. 4,4'-Dichloro-2,2'-methylenediphenol
- [A nontoxic laxative vermicide of chlorinated phenol compound. Dichlorophen is used as a veterinary fungicide, anthelmintic, and anti-protozoan, as well as an ingredient in antimicrobial soaps and shampoos. This agent probably acts by increasing the clearing of intestinal contents, thereby eradicating tapeworm infections from the intestines. ( NCI )] (UMLS (NCI) C0012082) =Organic Chemical; Pharmacologic Substance
| - 44. microalbuminuria
- [ ] (UMLS (CSP) C0730345) =Disease or Syndrome
|
- 22. 4,4'-Dichloro-3-(trifluoromethyl)-carbanilide
- [A synthetic, carbanilide compound with antiseptic activity. Cloflucarban is used as disinfectant and is found in antimicrobial soaps and deodorants. ( NCI )] (UMLS (NCI) C0055912) =Organic Chemical; Pharmacologic Substance ;
| - 45. [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic Acid
- [An aryloxy-acetic acid derivative belonging to the class of loop diuretics. Ethacrynic acid interferes with the chloride binding site of the Na+, K+, Cl- cotransporter system in the thick ascending loop of Henle, thereby inhibiting the reabsorption of sodium, potassium, and chloride ions. This leads to an increase in the excretion of sodium, potassium, chloride, calcium, and water. ( NCI )] (UMLS (NCI) C0014963) =Organic Chemical; Pharmacologic Substance ;
=phenoxyacetate; [CV702] LOOP DIURETICS =ETHACRYNATE; Ethacrynate 25 MG; Ethacrynate 50 MG; |
- 23. 5,7-Dichloro-8-hydroxyquinoline
- [A synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema. ( NCI )] (UMLS (NCI) C0055461) =Organic Chemical; Pharmacologic Substance =Chloroquinolinols;
[DE400] SOAPS/SHAMPOOS/SOAP-FREE CLEANSERS =CHLOROXINE 2 % | |