Dextropropoxyphene Hydrochloride
[The hydrochloride salt form of dextropropoxyphene, the d-isomer of propoxyphene, a synthetic diphenyl propionate derivative, with narcotic analgesic effect. Mimics the effects of endogenous opiates, dextropropoxyphene, binds to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, through which inactivates effector adenylate cyclase thereby decreases intracellular cAMP. This inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability which further decreases the perception of pain. ( NCI )]
UMLS (NCI) C0242451- Organic Chemical
- Pharmacologic Substance
Relation/PAR: PROPOXYPHENE
Propoxyphene Napsylate
Propoxyphene Napsylate
Relation/CHD: PROPOXYPHENE HYDROCHLORIDE 65 MG
PROPOXYPHENE HYDROCHLORIDE 32 MG
PROPOXYPHENE HYDROCHLORIDE 32 MG
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