[Encoded by human DSS1 Gene (DSS1/SEM1 Family), 70-amino acid 8 kD DSS1 Protein is a highly conserved acidic protein predominantly expressed in limb bud, craniofacial primordia, and skin. A human homolog of the highly conserved cytosolic SEM1 (S. cerevisiae), DSS1 may be involved in completion of the cell cycle or in a differentiation process. Containing three oligonucleotide-binding folds and a helix-turn-helix motif, DSS1 Protein directly interacts with a 90 kD C-terminal domain of BRCA2 that binds single-stranded DNA. (from Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0665881 - Amino Acid, Peptide, or Protein
- Biologically Active Substance
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