DR1-Associated Corepressor
[Encoded by human DRAP1 Gene, DR1-Associated Protein 1 is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 interacts with the TATA-binding protein (TBP) of TFIID and prevents formation of an active transcription complex by precluding TFIIA and/or TFIIB entry into the preinitiation complex. DRAP1 and DR1 interaction is required for corepressor function and stabilizes the TBP-DR1-DNA complex. DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes. (NCI) ( NCI )]
UMLS (NCI) C0388904- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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