- 1. DRTF1
- [Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver, human TFDP2 Gene (E2F/DP Family) encodes alternative isoforms alpha (446-aa, 49-kDa), beta (369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear Transcription Factor Dp-2, which in a heterodimeric complex with E2F family members regulates genes required for G1/S cell-cycle progression, S-phase progression, cell cycle regulation, DNA replication, or apoptosis. TFDP2 binds DNA cooperatively with E2F through the E2 recognition site, TTTCC/GCGC. Interact of DP/E2F with hypophosphorylated RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex. (NCI) ( NCI )] (UMLS (NCI) C0528328) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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