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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DE DEA DEB DEC DED DEE DEF DEG DEH DEI DEJ DEK DEL DEM DEN DEO DEP DEQ DER DES DET DEU DEV DEX DEZ

DESONIDE

[A synthetic glucocorticosteroid for topical use, with anti-inflammatory activity. Desonide binds to glucocorticoid receptors in the cytoplasm, and the ligand-receptor complex is translocated as a homodimer into the nucleus, where transcription activation via glucocorticoid response elements within glucocorticoid-responsive genes occur. This agent induces transcription of genes coding for anti-inflammatory proteins, including lipocortin-1, interleukin-10, interleukin-1 receptor antagonist and neutral endopeptidase. Increased synthesis of lipocortin-1 has an inhibitory effect on phospholipase A2, which in turn inhibits the release arachidonic acid, thereby controlling the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. ( NCI )]
UMLS (NCI) C0011705
 
Steroid
Pharmacologic Substance
Relation/PAR: Pregnadienetriols
[DE200] ANTI-INFLAMMATORY, TOPICAL
Relation/CHD: DESONIDE 0.05 %

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