DEK
[Encoded by human DEK Gene, ubiquitous 375-amino acid 43-kD nuclear RNA- and DNA-binding DEK Protein contains a SAP domain and appears to be involved in transcriptional regulation and signal transduction. Most is associated with chromatin, a fraction with RNA. The amount and localization does not change during the cell cycle. DEK binds the HIV-2 'pets' site, interacts with histones, DAXX, and HDAC2, and induces superhelical chromatin alterations with TOP1 or TOP2A. It does not induce histone displacement, but changes nucleosomal DNA topology, and reduces replication efficiency. DEK is a spliced exon-associated spliceosome component mediated by SR protein interactions, such as SRM160. AML-associated t(6;9)(p23;q34) creates fused DEK to CAN with no ORF interruption. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0249747- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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