UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DA DAA DAB DAC DAD DAF DAG DAI DAK DAL DAM DAN DAP DAR DAS DAT DAU DAV DAW DAX DAY

DAXX

[Encoded by human DAXX Gene (DAXX Family), ubiquitous nuclear/cytoplasmic Death Domain-Associated Protein 6 is a 740-amino acid 81.4-kD sumoylated putative phosphohomomultimer with NLS, Glu-rich, and JNK activation domains. Bound to TGFBR2 and TNFRSF6 FAS death domain via C-terminus, DAXX bridges apoptotic FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may block TNFRSF6/ASK1. DAXX co-represses transcription by recruitment to nucleoli or PML/POD/ND10 nuclear bodies through interaction with MCSR1 or PML and directly inhibits PAX3 and ETS1. As part of PAX5/CREBBP complex, DAXX may modulate PAX5 activity. DAXX binds to SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, and histones H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0541030
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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