- 1. DAB(389)IL-2
- (UMLS (NCI) C0211023) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
| - 3. DAB389 EGF
- [A recombinant fusion protein composed of the diphtheria toxin with the receptor-binding domain replaced by human epidermal growth factor (EGF). When administered, EGF binds to the endothelial cell growth factor receptor, EGFR, which is upregulated in many solid tumors. After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (NCI04) ( NCI )] (UMLS (NCI) C0281573) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
|
- 2. DAB2
- [This gene is involved in the regulation of cell proliferation. ( NCI )] (UMLS (NCI) C1333202) DAB2 Gene;
Disabled Homolog 2, Mitogen-Responsive Phosphoprotein (Drosophila) Gene =Gene or Genome ;
◊ [Encoded by human tumor suppressor DAB2 Gene, Disabled Homolog 2 Protein is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1333302) DAB2 Protein; Differentially Expressed in Ovarian Cancer 2; Differentially Expressed Protein 2; Disabled Homolog 2; Disabled Homolog 2 Protein; Disabled Homolog 2, Mitogen-Responsive Phosphoprotein; DOC2; DOC-2; Mitogen-Responsive Phosphoprotein Amino Acid, Peptide, or Protein; Biologically Active Substance | - 4. Dabska Tumor
- [An intermediate, rarely metastasizing blood vessel neoplasm. It is characterized by the presence of lymphatic like vascular channels and papillary endothelial proliferation. ( NCI )] (UMLS (NCI) C0346087) =Neoplastic Process
|
home
