[An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release. ( NCI )]
UMLS (NCI) C0700532 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: DIHYDROERGOTAMINE
Relation/CHD: DIHYDROERGOTAMINE MESYLATE 1 MG/ML
DIHYDROERGOTAMINE MESYLATE 4 MG/ML