7,8-Didehydro-4,5-epoxy- 3-methoxy-17-methyl-(5a ,6a)-Morphinan-6-ol Sulfate (2:1)
[The sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of codeine sulfate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability. ( NCI )]
UMLS (NCI) C0304352- Organic Chemical
- Pharmacologic Substance
Relation/PAR: codeine
Relation/CHD: CODEINE SULFATE 10 MG
CODEINE SULFATE 30 MG
CODEINE SULFATE 10 MG/5ML
CODEINE SULFATE 60 MG
CODEINE SULFATE 15 MG
CODEINE SULFATE 30 MG
CODEINE SULFATE 10 MG/5ML
CODEINE SULFATE 60 MG
CODEINE SULFATE 15 MG
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