[An antibiotic isolated from Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways including the synthesis of D-glucosamine phosphate, purines and pyrimidines. As an L-glutamine antagonist, diazooxonorleucine inhibits phosphate-activated glutaminase, thereby interfering with glutamine metabolism, ultimately depleting cells of this essential amino acid and reducing the capacity to proliferate. Another mechanism of action including inhibition of glycoprotein, gamma-guanosine triphosphatease, DNA and RNA synthesis has been proposed. ( NCI )]
UMLS (NCI) C0012020 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance
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