4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide
[A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. ( NCI )]
UMLS (NCI) C0252643- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CV900] CARDIOVASCULAR AGENTS, OTHER
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: BOSENTAN 125 MG
BOSENTAN 62.5 MG
BOSENTAN 62.5 MG
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