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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DE DEA DEB DEC DED DEE DEF DEG DEH DEI DEJ DEK DEL DEM DEN DEO DEP DEQ DER DES DET DEU DEV DEX DEZ

4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine

[A novel fluorinated Vinca alkaloid with antiangiogenic and antitumor activities. Although the exact mechanism of the mitotic block is not clear, vinflunine could induce cell cycle arrest at G2/M phase, and cause a concentration-dependent reduction of the microtubular network of interphase cells, thereby leading to apoptosis. This agent appears to function as an inhibitor of tubulin assembly, while exhibiting quantitatively different behaviors and showing lower binding capacity than the classic Vinca alkaloids. Furthermore, vinflunine exhibits improved pharmacokinetic properties, including increased lipophilicity, and is more resistant to metabolic degradation. ( NCI )]
UMLS (NCI) C0672663
 
Organic Chemical
Pharmacologic Substance

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