[A nonsteroidal anti-inflammatory drug (NSAID) derivative of oxazole-propionic acid with analgesic and antipyretic properties. As a first generation NSAID inhibitor, oxaprozin binds to and inactivates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins. When inhibiting COX-2, this agent may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. (NCI04) ( NCI )]
UMLS (NCI) C0069739 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: Propionic Acids
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC
Relation/CHD: OXAPROZIN 600 MG