[A tricyclic nucleoside with potential antineoplastic activity. As a purine analog, triciribine phosphate inhibits the enzymes amidophosphoribosyltransferase and inosine monophosphate dehydrogenase, resulting in decreased purine nucleotide biosynthesis, decreased DNA and protein synthesis, and cell cycle arrest. This agent may also exhibit antiviral activity. (NCI04) ( NCI )]
UMLS (NCI) C0077070 - Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance