- 401. Allopathic & Osteopathic Physicians
- [A broad category grouping state licensed providers in allopathic or osteopathic medicine whose scope of practice is determined by education. ( HL7V3.0 )] (UMLS (HL7) C1555723) =Intellectual Product =NUCC Health Care Provider Taxonomy;
=pathologist;
surgeon;
Anesthesiology;
Clinical Pharmacology;
Colon & Rectal Surgery;
Dermatology;
Emergency Medicine;
Family Practice;
General Practice;
Internal Medicine;
Allergy & Immunology;
Legal Medicine;
Medical Genetics;
Neurological Surgery;
Neuromusculoskeletal Medicine & OMM;
Neuromusculoskeletal Medicine, Sports Medicine;
Nuclear Medicine;
Obstetrics & Gynecology;
Ophthalmology;
Oral & Maxillofacial Surgery;
Orthopaedic Surgery;
Otolaryngology;
Pain Medicine;
Pediatrics;
Physical Medicine & Rehabilitation;
Plastic Surgery;
Preventive Medicine;
Psychiatry & Neurology;
Urology;
Radiology;
Hospitalist | - 451. Alpha Cell
- [A cell in the periphery of the pancreatic islets that secretes glucagon. ( NCI )] (UMLS (NCI) C0030280) =Cell ;
|
- 402. allosteric site
- [enzyme site which binds molecule other than substrate, thereby regulating enzyme activity. ( CSP )] (UMLS (CSP) C0002146) =Functional Concept
| - 452. Alpha Cell Neoplasm
- [(GLOO-kuh-guh-NO-ma) A rare pancreatic tumor that produces a hormone called glucagon. Glucagonomas can produce symptoms similar to diabetes. ( NCI )] (UMLS (NCI) C0017689) =Neoplastic Process =Islet Cell Adenoma;
|
- 403. Allotransplantation of cells of Islets of Langerhans
- [ ] (UMLS (ICD9CM) C0375988) =Therapeutic or Preventive Procedure
| - 453. Alpha DNA polymerase
- [An enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis. ( NCI )] (UMLS (NCI) C0012888) =Amino Acid, Peptide, or Protein; Enzyme
|
- 404. Allovectin-7
- [A substance that is being studied as a gene therapy agent for the treatment of cancer. It increases the ability of the immune system to recognize cancer cells and kill them. ( NCI )] (UMLS (NCI) C0338269) =Nucleic Acid, Nucleoside, or Nucleotide; Lipid; Pharmacologic Substance
| - 454. Alpha Fetoprotein Increased
- (UMLS (NCI) C0235971) =Finding
|
- 405. Allovectin-7/Dacarbazine
- (UMLS (NCI) C0796407) =Therapeutic or Preventive Procedure
| - 455. alpha fucosidase deficiency
- [lysosomal storage disease caused by defective alpha-L-fucosidase and accumulation of fucose containing glycoconjugates; clinical symptoms include psychomotor deterioration, growth retardation, hepatosplenomegaly, cardiomegaly, and seizures. ( CSP )] (UMLS (CSP) C0016788) =Disease or Syndrome ;
=Carbohydrate Metabolism, Inborn Errors;
inborn lysosomal enzyme disorder;
enzyme deficiency;
Lysosomal Storage Diseases, Nervous System |
- 406. allovectin-7/IL-2
- (UMLS (NCI) C0338270) =Therapeutic or Preventive Procedure
| - 456. alpha galactosidase
- [hydrolyses terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. ( CSP )] (UMLS (CSP) C0002268) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 407. Allow generic substitutions.
- (UMLS (HL7) C1549520) =Idea or Concept =Allow Substitution;
| - 457. alpha galactosidase deficiency
- [x-linked lysosomal storage disease of glycosphingolipid catabolism, resulting from a deficiency of alpha-galactosidase A and leading to accumulation of ceramide trihexoside in the cardiovascular and renal systems. ( CSP )] (UMLS (CSP) C0002986) =Disease or Syndrome
|
- 408. Allow Substitution
- (UMLS (HL7) C1550434) =Functional Concept =HL7 Vocabulary Version 2.5;
=Allow generic substitutions.;
Substitutions are NOT authorized. (This is the default - null.);
Allow therapeutic substitutions;
| - 458. alpha globulin
- [blood plasma or serum protein that is alkaline and has great electrophoretic mobility. ( CSP )] (UMLS (CSP) C0002211) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 409. Allow Substitution Codes
- (UMLS (HL7) C1547681) =Intellectual Product =HL7 Vocabulary Version 2.5;
=Contact the Placer Contact Person prior to making any substitutions of this resource;
Substitution of this resource is not allowed;
Notify the Placer Contact Person, through normal institutional procedures, that a substitution of this resource has been made;
Substitution of this resource is allowed | - 459. alpha glucosidase
- [hydrolyses terminal, non-reducing 1,4-linked alpha-D- glucose residues with release of alpha-D-glucose. ( CSP )] (UMLS (CSP) C0002272) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 410. Allow therapeutic substitutions
- (UMLS (HL7) C1549522) =Idea or Concept =Allow Substitution;
| - 460. Alpha Heavy Chain Disease
- [A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain. It predominantly affects young people in the Mediterranean region. It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever. There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells. The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). Alpha heavy chain disease frequently progresses to large B-cell lymphoma, and normally has a poor prognosis. ( NCI )] (UMLS (NCI) C0021071) =Neoplastic Process ;
=HCD;
Intestinal Diseases;
lymphoma;
|
- 411. alloxan
- [pyrimidine ring with carbonyl oxygens at all 4 carbon atoms; an oxidation product of uric acid which, by destroying beta cells in the pancreas, can cause diabetes mellitus; an experimental antineoplastic. ( CSP )] (UMLS (CSP) C0002151) =Biologically Active Substance; Antibiotic ;
| - 461. alpha helix
- [A right-handed spiral conformation; the a-helix has a pitch of 5.4 A and has 3.6 amino acid residues per turn; every main chain C=O and N-H group is hydrogen-bonded to a peptide bond 4 residues away; the peptide planes are roughly parallel with the helix axis and the dipoles within the helix are aligned, i.e. all C=O groups point in the same direction and all N-H groups point the other way; side chains point outward from helix axis and are generally oriented towards its amino-terminal end. (from expasy.org) ( NCI )] (UMLS (CSP) C0599214) =Spatial Concept
|
- 412. alloy
- [mixture of two or more metals or of one or more metals with certain metalloids that are mutually soluble in the molten condition; distinguished as binary, ternary, quaternary, etc., depending on the number of metals in the mixture. ( CSP )] (UMLS (CSP) C0002154) =Biomedical or Dental Material; Inorganic Chemical ;
| - 462. alpha hydroxyketone
- [ ] (UMLS (CSP) C0598751) =Organic Chemical ;
|
- 413. Allural
- (UMLS (NCI) C1449513) =Organic Chemical; Pharmacologic Substance
| - 463. Alpha Inhibin
- [The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. (LocusLink) ( NCI )] (UMLS (NCI) C0299209) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 414. allyl compound
- [substance that consists of two or more chemical elements in union and containing the univalent organic group, -CH2 or allyl. ( CSP )] (UMLS (CSP) C0002156) =Organic Chemical
| - 464. Alpha Interferon
- [A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04) ( NCI )] (UMLS (NCI) C0751598) alpha-Interferon;
Interferon Alfa;
Leukocyte Interferon;
Lymphoblast Interferon;
Lymphoblastoid Interferon;
Recombinant Interferon Alfa;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance |
- 415. allylamine
- [Possesses an unusual and selective cytotoxicity for vascular smooth muscle cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation. ( MSH )] (UMLS (CSP) C0002157) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 465. alpha ketoglutarate
- [intermediate in the Krebs' cycle; also produced from glutamate in amino group transfer reactions and by oxidative deamination. ( CSP )] (UMLS (CSP) C1291208) =Organic Chemical; Pharmacologic Substance =glutarate;
|
- 416. Almotriptan
- (UMLS (NCI) C0914729) ALMOTRIPTAN PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=[CN105] ANTIMIGRAINE AGENTS;
Unclassified Ingredients =Almotriptan Malate;
| - 466. alpha ketoglutarate dehydrogenase
- [component of a multi-enzyme complex which decarboxylates alpha ketoglutarate to form succinyl coA in the Krebs' cycle. ( CSP )] (UMLS (CSP) C0022626) =Amino Acid, Peptide, or Protein; Enzyme =aldehyde/ketone oxidoreductase;
respiratory enzyme |
- 417. Almotriptan Malate
- [The malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to a relief in pain from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve. ( NCI )] (UMLS (NCI) C0937898) ALMOTRIPTAN MALATE PREPARATION;
=Organic Chemical; Pharmacologic Substance ;
=Almotriptan;
Unclassified Ingredients =ALMOTRIPTAN MALATE 6.25 MG;
ALMOTRIPTAN MALATE 12.5 MG | - 467. alpha L fucosidase
- [An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51. ( MSH )] (UMLS (CSP) C0016787) =Amino Acid, Peptide, or Protein; Enzyme
|
- 418. ALN
- [Lymph nodes found in the armpit that drain the lymph channels from the breast. ( NCI )] (UMLS (NCI) C0729594) Axillary Lymph Node;
Axillary Lymph Nodes;
Axillary Node =Body Part, Organ, or Organ Component ;
| - 468. Alpha L Integrin Chain
- [Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink) ( NCI )] (UMLS (NCI) C0079091) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 419. Alocril
- (UMLS (NCI) C0876882) =Organic Chemical; Pharmacologic Substance
| - 469. alpha mannosidase
- [An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS. ( MSH )] (UMLS (CSP) C0051350) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 420. ALOE
- [A plant genus of the family Aloeaceae, order Liliales (or Asphodelaceae, Asparagales in APG system) which is used medicinally. It contains anthraquinone glycosides such as aloin-emodin or aloe-emodin (EMODIN). ( MSH )] (UMLS (NCI) C0002168) =Plant
| - 470. alpha methyl p tyrosine
- [An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed) ( MSH )] (UMLS (CSP) C0051427) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=Methyltyrosines;
|
- 421. Aloe Vera Gel
- [Obtained as a preparation of leaf pulp from the parenchymal tissue of Aloe vera (Liliaceae) and containing carbohydrate polymers, such as glucomannans or pectic acid; various vitamins and essential amino acids; as well as other organic and inorganic compounds, Aloe Vera Gel is used internally or externally for sunburn, skin problems, insect bites, ulcers, arthritis, constipation, and as an immune system enhancer. (NCI04) ( NCI )] (UMLS (NCI) C0974143) ALOE VERA GEL (GM);
ALOE VERA GEL PREPARATION;
ALOE VERA GEL,TOP;
ALOE VERA TOPICAL GEL (GM);
Aloe Vera, topical gel =Clinical Drug =Aloe Vera Gel;
ALOE VERA =Aloe Vera Gel;
CARA-KLENZ,SKIN & WOUND CLEANSER;
I.S.P. LOTION;
Menthol 0.07 MG/MG Topical Gel;
MICRO-KLENZ,ANTIMICROBIAL WOUND CLEANSER;
CARRINGTON WHIRLPOOL SOLN;
CARRINGTON DRESSING GEL SPRAY,TOP;
CARRINGTON GEL,TOP | - 471. alpha methyldopamine
- [decarboxylation product of the antihypertensive METHYLDOPA. ( CSP )] (UMLS (CSP) C0051413) =Organic Chemical =catecholamine;
|
- 422. ALOMAD
- (UMLS (NCI) C0279217) =Therapeutic or Preventive Procedure
| - 472. alpha N acetylglucosaminidase
- [ ] (UMLS (CSP) C0051437) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 423. Alone
- (UMLS (HL7) C0439044) =Finding =Living Arrangement;
| - 473. Alpha Naphthyl Acetate Esterase Stain
- [A cytochemical staining technique to detect alpha-naphthyl acetate esterase (ANAE) activity. Nonspecific esterase stains with acetate substrate and is mainly used in the determination of lineage in acute myelogenous leukemia. Acute megakaryoblastic leukemia (M7) blasts stain strongly when the acetate substrate is used. ( NCI )] (UMLS (NCI) C1294078) Alpha Naphthyl Acetate Esterase Staining Method;
=Laboratory Procedure |
- 424. alopecia
- [baldness; absence of hair from skin areas where it is normally present. ( CSP )] (UMLS (CSP) C0002170) =Finding
| - 474. Alpha Naphthyl Butyrate Esterase Stain
- [A cytochemical staining technique to detect esterase enzyme contained within monocytes and macrophages, which reacts strongly with the substrate alpha-naphthyl butyrate. Monoblastic [FAB M5a (without differentiation) or M5b (with differentiation)] and acute myelomonocytic (M4) leukemias have staining in blasts when the butyrate substrate is employed. Myeloid cells (either malignant or non-malignant) do not stain with nonspecific esterase techniques. ( NCI )] (UMLS (NCI) C1293962) Alpha Naphthyl Butyrate Esterase Staining Method;
Alpha Naphthyl Esterase Stain;
Alpha Naphthyl Esterase Staining Method;
Butyrate-esterase stain =Laboratory Procedure =ObservationMethod;
|
- 425. Alopecia areata
- [A microscopically inflammatory, usually reversible, patchy hair loss occurring in sharply defined areas and usually involving the beard or scalp. (Dorland, 27th ed) ( MSH )] (UMLS (ICD9CM) C0002171) =Disease or Syndrome
| - 475. Alpha Particle Radiation
- [radioactive decay particles consisting of a helium nucleus (2p2n++) ejected at high speed. ( CSP )] (UMLS (NCI) C0002217) =Natural Phenomenon or Process; Physical Object ;
|
- 426. ALOPECIA NEC
- [ ] (UMLS (ICD9CM) C0029489) =Disease or Syndrome
| - 476. Alpha Platelet-Derived Growth Factor Receptor
- [Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, encoded by the PDGFRA gene, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink) ( NCI )] (UMLS (NCI) C0290067) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
|
- 427. Alouatta
- [A genus of the subfamily ALOUATTINAE, family ATELIDAE, inhabiting the forests of Central and South America. Howlers travel in groups and define their territories by howling accompanied by vigorously shaking and breaking branches. ( MSH )] (UMLS (CSP) C0002184) =Mammal
| - 477. alpha secretase
- [ ] (UMLS (CSP) C0379526) =Amino Acid, Peptide, or Protein; Enzyme
|
- 428. Alouattinae
- [A subfamily of ATELIDAE inhabiting the forests of Central and South America. The genus ALOUATTA, or howler monkeys, belongs to this subfamily. ( MSH )] (UMLS (CSP) C0085223) =Mammal
| - 478. alpha synuclein
- [brain protein of unknown function; mutation is associated with Parkinson's disease. ( CSP )] (UMLS (CSP) C0285890) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=nerve/myelin protein;
|
- 429. ALOVUDINE
- (UMLS (NCI) C0206795) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 479. alpha synuclein gene
- [ ] (UMLS (CSP) C0599963) =Gene or Genome ;
|
- 430. ALOX15
- [This gene is involved in hormonal signaling and inflammation. ( NCI )] (UMLS (NCI) C1332082) ALOX15 Gene;
Arachidonate 15-Lipoxygenase Gene;
=Gene or Genome | - 480. Alpha Thalassemia
- [A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted. ( MSH )] (UMLS (NCI) C0002312) =Disease or Syndrome
|
- 431. ALP
- [Encoded by human SLPI Gene, 132-aa 14-kDa (precursor) Secretory Leukocyte Protease Inhibitor is an acid-stable proteinase inhibitor with 2 WAP-type domains found in seminal plasma, cervical mucus, and bronchial secretions. With affinity for trypsin, chymotrypsin, leukocyte elastase, and cathepsin G, SLPI contributes to the immune response by protecting epithelial surfaces from attack by endogenous serine proteases. (NCI) ( NCI )] (UMLS (NCI) C0663932) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
| - 481. Alpha Therapeutic Corporation
- [Alpha Therapeutic Corporation ( HL7V3.0 )] (UMLS (HL7) C1546860) =Health Care Related Organization =Manufacturers of Vaccines (code=MVX);
VaccineManufacturer |
- 432. Alper's Syndrome
- (UMLS (NCI) C0205710) =Disease or Syndrome
| - 482. alpha(sup 6)-((tert-Butylamino)methyl)-3-hydroxy-2,6-pyridinedimethanol Monoacetate(salt)
- [The acetate salt form of pirbuterol, a synthetic catecholamine and a pyridine derivative with sympathomimetic and bronchodilatory effects. Pirbuterol acetate selectively stimulates beta-2 adrenergic receptors, resulting in initiation of intracellular adenylate cyclase activity leading to increased levels of cAMP. As a result muscle relaxation (broncho- and vasodilation) occurs via cAMP-dependent signal transduction. In addition, elevated levels of cAMP inhibit release of inflammatory mediators from mast cells. ( NCI )] (UMLS (NCI) C0724666) Pirbuterol Acetate;
PIRBUTEROL ACETATE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=PIRBUTEROL;
=PIRBUTEROL ACETATE 0.2 MG/ACTUAT |
- 433. alpha 1 acid glycoprotein
- [family of plasma proteins with oligosaccharide side chains or glycoproteins believed to be associated with inflammation. ( CSP )] (UMLS (CSP) C0029297) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=blood protein;
glycoprotein;
genetic marker;
| - 483. alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide
- [A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver. ( NCI )] (UMLS (NCI) C0754659) Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide;
DUTASTERIDE;
DUTASTERIDE UNIDENTIFIED;
DUTASTERIDE PREPARATION;
DUTASTERIDE UNIDENTIFIED =Organic Chemical; Pharmacologic Substance ;
=[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
Unclassified Ingredients =DUTASTERIDE 0.5 MG;
|
- 434. alpha 1 antitrypsin
- [inflammation-inducible serine protease inhibitor synthesized primarily in liver, then secreted into blood where it accounts for the bulk of blood protease inhibitor activity; is an important regulator of neutrophil elastase. ( CSP )] (UMLS (CSP) C0002191) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance
| - 484. alpha-(1-[tert-Butylamino]ethyl)-2,5-dimethoxybenzyl Alcohol Hydrochloride
- [The hydrochloride salt form of butoxamine, a selective beta-2 adrenergic antagonist. Butoxamine is used primarily in animal and tissue experiments to identify beta-2 receptors and their function. ( NCI )] (UMLS (NCI) C0282081) =Organic Chemical; Pharmacologic Substance ;
|
- 435. alpha 1 antitrypsin deficiency
- [autosomal recessive trait leading to destruction of lung tissue by neutrophil elastase and eventual emphysema; second only to cystic fibrosis as most common lethal genetic disorder among Caucasians of northern European ancestry. ( CSP )] (UMLS (CSP) C0221757) =Disease or Syndrome ;
=Connective Tissue Disease;
Congenital Metabolic Disorder | - 485. alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol
- [alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; an antifungal with potential efficacy for patients unable to take amphotericin B or who are immunologically compromised, as in AIDS. ( CSP )] (UMLS (NCI) C0016277) =Organic Chemical; Pharmacologic Substance ;
=[AM700] ANTIFUNGALS;
Triazoles =FLUCONAZOLE 100 MG;
FLUCONAZOLE 150 MG;
FLUCONAZOLE 2 MG/ML;
FLUCONAZOLE 200 MG;
FLUCONAZOLE 50 MG;
FLUCONAZOLE 10 MG/ML;
FLUCONAZOLE 40 MG/ML |
- 436. Alpha 1 Type I Collagen
- [Collagen I (Alpha 1), encoded by the COL1A1 gene, is the major component of type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (from LocusLink) ( NCI )] (UMLS (NCI) C0972255) COL1A1;
Collagen Alpha 1(I) Chain;
Collagen I (Alpha 1);
Collagen I, Alpha-1 Polypeptide;
Collagen of Skin, Tendon and Bone, Alpha-1 Chain;
Collagen of Skin, Tendon, and Bone, Alpha-1 Chain;
Collagen, Type I, Alpha 1;
Osteogenesis Imperfecta Type IV;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 486. alpha-(2-chloro-4-(4,6-diamino-2,2-dimethyl-s-trizin-1(2H)-yl)phenoxy)-N,N-dimethyl-m-toluamide ethanesulfonic acid
- [A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI04) ( NCI )] (UMLS (NCI) C0077008) =Organic Chemical; Pharmacologic Substance ;
|
- 437. alpha 2 agonist
- [ ] (UMLS (CSP) C0599679) =Pharmacologic Substance
| - 487. alpha-1,3,5-triglycidyl-s-triazinetrione
- [A triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replication. (NCI04) ( NCI )] (UMLS (NCI) C0043891) =Organic Chemical; Pharmacologic Substance ;
|
- 438. Alpha 2 Interferon
- [A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04) ( NCI )] (UMLS (NCI) C0021734) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor =[IM700] IMMUNE STIMULANTS;
IFNa;
Interferon Type I, Recombinant;
Alpha 2 Interferon =Alpha 2 Interferon;
Interferon Alfa-2a 3000000 UNT/ML;
Interferon Alfa-2a 6000000 UNT/ML;
Interferon Alfa-2a 36000000 UNT/ML;
Interferon Alfa-2a 18000000 UNT;
INTERFERON ALFA-2A,RECOMBINANT 3 MILLION UNT/SYR;
INTERFERON ALFA-2A,RECOMBINANT 9 MILLION UNT/SYR;
INTERFERON ALFA-2A,RECOMBINANT 9MILLION UNT;
| - 488. Alpha-1,4-N-acetylhexosaminyltransferase EXTL2
- [Ubiquitously expressed by human EXTL2 Gene (EXT Family), 330-aa 37.5-kDa Exostosin-Like 2 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI) ( NCI )] (UMLS (NCI) C1308415) Alpha-GalNAcT EXTL2;
Exostosin-Like 2 Protein;
EXTL2;
EXT-Related Protein 2;
=Amino Acid, Peptide, or Protein; Enzyme |
- 439. Alpha 2 Type I Collagen
- [Collagen I (Alpha 2), encoded by the COL1A2 gene, is one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes. (from LocusLink) ( NCI )] (UMLS (NCI) C0766823) COL1A2;
Collagen Alpha 2(I) Chain;
Collagen I (Alpha 2);
Collagen I, Alpha-2;
Collagen of Skin, Tendon and Bone, Alpha-2 Chain;
Collagen of Skin, Tendon, and Bone, Alpha-2 Chain;
Collagen, Type I, Alpha-2 =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
| - 489. Alpha-Beta-Omega Interferon Receptor-1
- [Encoded by human IFNAR1 Gene (Type II Cytokine Receptor Family), 557-aa 64-kDa (precursor) ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Alpha Chain contains 3 fibronectin type III domains and is the alpha subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI) ( NCI )] (UMLS (NCI) C0380190) =Amino Acid, Peptide, or Protein; Receptor
|
- 440. Alpha 3 Type IV Collagen Precursor
- [Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C1314894) COL4A3;
COL4A3 Protein;
COL4A3BP Protein;
Collagen IV (Alpha 3);
Collagen IV, Alpha-3 Polypeptide;
Collagen of Basement Membrane, Alpha-3 Chain;
Collagen Type IV Alpha 3 Binding Protein;
Collagen, Type IV, Alpha 3 (Goodpasture Antigen);
EC 2.7.1.37;
Goodpasture Antigen;
GPBP Protein;
STARD11 Protein;
STAR-Related Lipid Transfer Protein 11;
START Domain-Containing Protein 11;
TUMSTATIN;
Tumstatin (Human Placenta Collagen Type IV alpha3 Chain NC1 Domain) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 490. Alpha-Beta-Omega Interferon Receptor-2
- [Encoded as 515-aa 58-kDa (precursor), 331-aa, and 515-aa isoforms by human IFNAR2 Gene (Type II Cytokine Receptor Family), ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Beta Chain is the beta subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. IFNAR2 interacts with RACK1. (NCI) ( NCI )] (UMLS (NCI) C0254653) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 441. Alpha 4 Protein
- [Ubiquitously expressed (highest in heart, skeletal muscle, and pancreas) by human IGBP1 Gene, 339-aa 39-kDa Immunoglobulin Binding Protein 1 is likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI) ( NCI )] (UMLS (NCI) C1334162) B Cell Signal Transduction Molecule Alpha 4;
CD79A-Binding Protein 1;
IGBP1;
Immunoglobulin (CD79A) Binding Protein 1;
Immunoglobulin Binding Protein 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 491. alpha-D-glucopyranoside, methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-6-deoxy-
- [A chloroethylnitrosourea derivative that inhibits proliferation and growth of tumor cells by alkylation and cross-linkage of DNA strands of tumor cells. (NCI) ( NCI )] (UMLS (NCI) C0243666) =Organic Chemical; Pharmacologic Substance ;
|
- 442. alpha actinin
- [cytoskeletal protein present in Z lines of muscle fibrils and at sites of non-muscle cell contact with a substrate. ( CSP )] (UMLS (CSP) C0917705) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=ABP;
| - 492. Alpha-Difluoromethylornithine
- [An antiprotozoal drug that is being studied for cancer prevention. ( NCI )] (UMLS (NCI) C0002260) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 443. alpha adrenergic agent
- [drugs that selectively bind to and activate alpha adrenergic receptors. ( CSP )] (UMLS (CSP) C0178469) =Pharmacologic Substance =adrenergic agent;
| - 493. Alpha-Fucosyltransferases
- [Belongs to the family of EC 2.4.1 glycosyltransferases. The enzyme catalyzes the transfer o f fucose molecule from dinucleotide compound to another carbohydrate compound. ( NCI )] (UMLS (NCI) C0016790) =Amino Acid, Peptide, or Protein; Enzyme
|
- 444. alpha adrenergic receptor
- [alpha-1 is coupled to phospholipase C, such that stimulation results in production of second messengers DAG and in inositol phosphates; alpha-2 is coupled to adenylate cyclase such that stimulation lowers cyclic AMP. ( CSP )] (UMLS (CSP) C0034784) =Amino Acid, Peptide, or Protein; Receptor ;
=adrenergic receptor;
| - 494. Alpha-methylacyl-CoA Racemase Gene
- [This gene plays a role in the formation of cholic acid in peroxisomes. ( NCI )] (UMLS (NCI) C1412374) AMACR;
AMACR Gene;
RACE;
=Gene or Genome ;
|
- 445. Alpha Adrenergic Receptor Gene
- [Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptor Genes encode Alpha Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. ( NCI )] (UMLS (NCI) C1332237) =Gene or Genome ;
| - 495. alpha-Phenyl-2-piperidineacetic Acid Methyl Ester
- [central stimulant used in treatment of hyperkinetic children, various types of depression, and narcolepsy. ( CSP )] (UMLS (NCI) C0025810) =Organic Chemical; Pharmacologic Substance ;
=[CN800] CNS STIMULANTS;
phenylacetate;
piperidine;
Piperidines;
[CN802] AMPHETAMINE-LIKE STIMULANTS;
=alpha-Phenyl-2-piperidineacetic Acid Methyl Ester Hydrochloride;
METHYLPHENIDATE 27 MG;
|
- 446. alpha aminoisobutyrate
- [ ] (UMLS (CSP) C0102457) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 496. alpha-Phenyl-2-piperidineacetic Acid Methyl Ester Hydrochloride
- [The hydrochloride salt of methylphenidate, a synthetic central nervous system stimulant. Methylphenidate appears to activate the brain stem arousal system and cortex to produce its stimulant effect and, in some clinical settings, may improve cognitive function. ( NCI )] (UMLS (NCI) C0700545) =Organic Chemical; Pharmacologic Substance ;
=alpha-Phenyl-2-piperidineacetic Acid Methyl Ester;
=METHYLPHENIDATE HYDROCHLORIDE 5 MG;
METHYLPHENIDATE HYDROCHLORIDE 10 MG;
METHYLPHENIDATE HYDROCHLORIDE 20 MG;
METHYLPHENIDATE HYDROCHLORIDE 36 MG;
METHYLPHENIDATE HYDROCHLORIDE 18 MG;
METHYLPHENIDATE HYDROCHLORIDE 54 MG;
METHYLPHENIDATE HYDROCHLORIDE 40 MG;
METHYLPHENIDATE HYDROCHLORIDE 30 MG;
|
- 447. alpha amylase
- [An enzyme that catalyzes the endohydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and related polysaccharides and oligosaccharides containing 3 or more 1,4-alpha-linked D-glucose units. EC 3.2.1.1. ( MSH )] (UMLS (CSP) C0002245) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
| - 497. alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic Acid
- [A quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense. ( NCI )] (UMLS (NCI) C0069562) =Organic Chemical; Pharmacologic Substance ;
|
- 448. alpha carboxylase
- [also another name for EC 1.2.4.1, PYRUVATE DEHYDROGENASE, do not confuse. ( CSP )] (UMLS (CSP) C0034342) =Amino Acid, Peptide, or Protein; Enzyme ;
=carboxy lyase;
| - 498. alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
- [calcium channel blocker that dilates coronary arteries and decreases myocardial oxygen demand. ( CSP )] (UMLS (NCI) C0042523) =Organic Chemical; Pharmacologic Substance ;
=[CV300] ANTIARRHYTHMICS;
[CV200] CALCIUM CHANNEL BLOCKERS;
Phenethylamines;
coronary vasodilator;
[CV250] ANTIANGINALS;
=(+-)-Verapamil hydrochloride;
VERAPAMIL 300 MG;
|
- 449. alpha catenin
- [A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN. ( MSH )] (UMLS (CSP) C0108280) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 499. Alpha-[tert-butylaminomethyl]-3,4- dihydroxybenzyl alcohol 3,4-di(p-toluate) Methanesulfonate
- [The mesylate salt of bitolterol, a diester sympathomimetic amine with bronchodilator activity. As an ester prodrug, bitolterol is hydrolyzed by esterases to its active metabolite colterol (N-t-butylarterenol). Colterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of bronchial smooth muscle. This increases air flow and prevents bronchospasms and may eventually lead to an improvement of airway function. ( NCI )] (UMLS (NCI) C0106575) =Organic Chemical; Pharmacologic Substance =BITOLTEROL;
|
- 450. alpha caveolin
- [ ] (UMLS (CSP) C0287872) =Amino Acid, Peptide, or Protein; Receptor
| - 500. alpha2 macroglobulin receptor
- [ ] (UMLS (CSP) C0598787) =Amino Acid, Peptide, or Protein; Receptor
|
home
