- 1. (+)-alpha-Tocopherol
- [A naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04) ( NCI )] (UMLS (NCI) C0969677) .alpha. Tocopherol;
3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol;
alpha Tocopherol;
ALPHA-TOCOPHEROL;
d-Alpha-Tocopherol;
Tocopherol-Alpha;
Tocopherol-D-Alpha;
=Lipid; Pharmacologic Substance; Vitamin | - 51. 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with Acetone
- [A synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Flurandrenolide exerts its effects by interacting with specific cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions. ( NCI )] (UMLS (NCI) C0016374) =Steroid; Pharmacologic Substance; Hormone =Pregnenediones;
Steroids, Fluorinated;
[DE200] ANTI-INFLAMMATORY, TOPICAL;
=FLURANDRENOLIDE 4 MCG/SQC;
FLURANDRENOLIDE 0.05 %;
FLURANDRENOLIDE 0.025 %;
|
- 2. (+)-alpha-Tocopherol Acetate
- [The acetate ester of a fat-soluble vitamin with potent antioxidant properties. Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols). This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04) ( NCI )] (UMLS (NCI) C0078373) =Organic Chemical; Pharmacologic Substance; Vitamin =(+/-)-alpha-Tocopherol;
(+)-alpha-Tocopherol Acetate;
Unclassified Ingredient Preparations;
=(+)-alpha-Tocopherol Acetate;
THICKENUP POWDER;
TOCOPHERYL ACETATE,ALPHA 15 MG;
TOCOPHERYL ACETATE,ALPHA 30 UNT;
OMEGA-3 (N-3) POLYUNSATURATED FATTY ACIDS 1GM CAP;
TOCOPHERYL ACETATE,D-ALPHA 30 MG;
VITAMIN E ACETATE 30 IU;
VITAMIN E ACETATE 30 UNT;
| - 52. 6alpha-Methyl-11-oxoprogesterone
- [The basic, partial chemical structure of corticosteroid hormones such as cortisone and aldosterone. (NCI04) ( NCI )] (UMLS (NCI) C0099478) =Organic Chemical; Pharmacologic Substance ;
|
- 3. (+-)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl Alcohol Sulfate(2:1)(salt)
- [The sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating and tocolytic properties. Terbutaline sulfate selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic cAMP production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids the relaxation of airway muscles. Terbutaline sulfate also increases mucociliary clearance and reduces release of inflammatory cell mediators. ( NCI )] (UMLS (NCI) C0039543) =Organic Chemical; Pharmacologic Substance ;
=TERBUTALINE;
=TERBUTALINE SULFATE 1 MG/ML;
TERBUTALINE SULFATE 2.5 MG;
TERBUTALINE SULFATE 5 MG | - 53. 7-(alpha-(4-Pyridylthio)acetamido)cephalosporanic acid sodium salt
- [The sodium salt form of cephapirin, a semi-synthetic, broad-spectrum, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephapirin sodium inhibits bacterial cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis and subsequent cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and leads to cell lysis. ( NCI )] (UMLS (NCI) C0085905) =Organic Chemical; Antibiotic =7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic Acid;
=cephapirin 1 gm injectable powder for injection |
- 4. (+/-)-alpha-Tocopherol
- [A substance used in cancer prevention. It belongs to the family of drugs called tocopherols. ( NCI )] (UMLS (NCI) C0042874) =Lipid; Pharmacologic Substance; Vitamin =benzopyran;
[DE350] EMOLLIENTS;
(+/-)-alpha-Tocopherol;
[VT000] VITAMINS =(+)-alpha-Tocopherol Acetate;
VITAMIN E OIL;
TOCOPHERYL ACID SUCCINATE,D-ALPHA;
TOCOPHEROL,DL-ALPHA;
(+)-alpha-Tocopherol Acetate;
AMINOBENZOIC ACID LOTION (ML);
PEPTAMEN LIQUID UNFLAVORED,250ML;
PEPTAMEN LIQUID VANILLA,250ML;
ALOE VERA/VITAMIN E OIL,TOP;
CARA-KLENZ,SKIN & WOUND CLEANSER;
CARRINGTON INCONTINENCE SKIN KIT;
ISOCAL HN (VANILLA) LIQUID,240ML;
ISOCAL LIQUID,CAN,240ML;
ISOCAL LIQUID,CAN,360ML; More… | - 54. 7alpha hydroxylase
- [nonEC. ( CSP )] (UMLS (CSP) C0599930) =Amino Acid, Peptide, or Protein; Enzyme =Oxygenase;
|
- 5. (-)-alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl Alcohol
- [The levoisomer of nordefrin, a synthetic catecholamine and norepinephrine derivative with sympathomimetic and antihypertensive effects. Levonordefrin's antihypertensive effect is exerted through activation of alpha 2-adrenergic receptors in the cardiovascular control center of the CNS thereby suppressing the sympathetic output from the brain and subsequently lowering blood pressure. Levonordefrin binds to and activates peripheral alpha 2- adrenergic receptors, thereby causing vasoconstriction. ( NCI )] (UMLS (NCI) C0520472) =Organic Chemical; Pharmacologic Substance ;
=Nordefrin;
[DE700] LOCAL ANESTHETICS, TOPICAL =LEVONORDEFRIN 1:20000 | - 55. 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester
- [A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerone is used in the treatment of hypertension and congestive heart failure. ( NCI )] (UMLS (NCI) C0961485) Eplerenone;
EPLERENONE PREPARATION;
=Steroid; Pharmacologic Substance =[CV704] POTASSIUM-SPARING/COMBINATIONS DIURETICS;
Unclassified Ingredients =EPLERENONE 25 MG;
EPLERENONE 50 MG;
EPLERENONE 100 MG;
|
- 6. (1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione
- [A potent fungal metabolite isolated from Penicillium wortmannin that selectively inhibits phosphatidylinositol 3-kinase and affects the signal transduction pathway. (NCI) ( NCI )] (UMLS (NCI) C0078517) =Steroid; Pharmacologic Substance; Biologically Active Substance
| - 56. 9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione
- [The acetonide salt form of triamcinolone, a synthetic glucocorticosteroid with immunosuppressive and anti-inflammatory activity. Triamcinolone acetonide binds to specific cytosolic glucocorticoid receptors and subsequently interacts with glucocorticoid receptor response element on DNA and alters gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. ( NCI )] (UMLS (NCI) C0040866) =Steroid; Pharmacologic Substance ;
=(11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;
[DE200] ANTI-INFLAMMATORY, TOPICAL;
[NT200] ANTI-INFLAMMATORIES, NASAL;
[OR900] DENTAL AND ORAL AGENTS, TOPICAL OTHER;
[RE101] ANTI-INFLAMMATORIES, INHALATION;
=(11beta,16alpha)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione;
TRIAMCINOLONE ACETONIDE PWDR;
TRIAMCINOLONE ACETONIDE 0.1 %;
TRIAMCINOLONE ACETONIDE 40 MG/ML;
TRIAMCINOLONE ACETONIDE 100 MCG/ACTUAT;
TRIAMCINOLONE ACETONIDE 10 MG/ML;
TRIAMCINOLONE ACETONIDE 55 MCG/ACTUAT;
TRIAMCINOLONE ACETONIDE 2.5 MG/GM;
TRIAMCINOLONE ACETONIDE 50 MCG/ACTUAT;
TRIAMCINOLONE ACETONIDE 3 MG/ML;
TRIAMCINOLONE ACETONIDE 3.3 MG/50GM;
TRIAMCINOLONE ACETONIDE 0.025 %;
TRIAMCINOLONE ACETONIDE 0.147 MG/GM;
TRIAMCINOLONE ACETONIDE 0.5 %;
TRIAMCINOLONE ACETONIDE 1 MG/GM |
- 7. (11alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid Methyl Ester
- [A radioprotective agent that belongs to the family of drugs called prostaglandins. ( NCI )] (UMLS (NCI) C0085174) =Eicosanoid; Pharmacologic Substance =Prostaglandins E, Synthetic;
[GA309] ANTIULCER AGENTS, OTHER =Misoprostol 0.2 MG;
Misoprostol 0.1 MG;
| - 57. ALP
- [Encoded by human SLPI Gene, 132-aa 14-kDa (precursor) Secretory Leukocyte Protease Inhibitor is an acid-stable proteinase inhibitor with 2 WAP-type domains found in seminal plasma, cervical mucus, and bronchial secretions. With affinity for trypsin, chymotrypsin, leukocyte elastase, and cathepsin G, SLPI contributes to the immune response by protecting epithelial surfaces from attack by endogenous serine proteases. (NCI) ( NCI )] (UMLS (NCI) C0663932) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 8. (11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid
- [The naturally occuring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP. ( NCI )] (UMLS (NCI) C0002335) =Eicosanoid; Pharmacologic Substance ;
| - 58. Alper's Syndrome
- (UMLS (NCI) C0205710) =Disease or Syndrome
|
- 9. (17-alpha)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one
- [A synthetic form of the naturally occurring female sex hormone progesterone. Etonogestrel binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. ( NCI )] (UMLS (NCI) C0047683) =Steroid; Pharmacologic Substance ;
=[HS200] CONTRACEPTIVES, SYSTEMIC;
Unclassified Ingredients =ETONOGESTREL 0.12 MG | - 59. alpha 1 acid glycoprotein
- [family of plasma proteins with oligosaccharide side chains or glycoproteins believed to be associated with inflammation. ( CSP )] (UMLS (CSP) C0029297) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=blood protein;
glycoprotein;
genetic marker;
|
- 10. (17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one
- [The levorotatory form of norgestrel and synthetic progestogen with progestational and androgenic activity. Levonorgestrel binds to the progesterone receptor in the nucleus of target cells, thereby stimulating the resulting hormone-receptor complex, initiating transcription, and increasing the synthesis of certain proteins. This results in a suppression of luteinizing hormone (LH) activity and an inhibition of ovulation, as well as an alteration in the cervical mucus and endometrium. ( NCI )] (UMLS (NCI) C0023566) =Steroid; Pharmacologic Substance; Hormone ;
=female antifertility drug;
(+/-)-13-Ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one;
[HS800] PROGESTINS;
[HS200] CONTRACEPTIVES, SYSTEMIC =LEVONORGESTREL 0.05 MG;
LEVONORGESTREL 0.15 MG;
LEVONORGESTREL 0.25 MG;
LEVONORGESTREL 0.1 MG;
LEVONORGESTREL 0.75 MG;
LEVONORGESTREL 36 MG;
LEVONORGESTREL 0.05-0.125 MG;
LEVONORGESTREL 52 MG;
| - 60. alpha 1 antitrypsin
- [inflammation-inducible serine protease inhibitor synthesized primarily in liver, then secreted into blood where it accounts for the bulk of blood protease inhibitor activity; is an important regulator of neutrophil elastase. ( CSP )] (UMLS (CSP) C0002191) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Biologically Active Substance
|
- 11. (17alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol
- [semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution; has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives. ( CSP )] (UMLS (NCI) C0015011) =Steroid; Pharmacologic Substance; Hormone =[HS300] ESTROGENS;
estrogen analog;
Norpregnatrienes;
=(17alpha)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol;
QUINESTROL;
ETHINYL ESTRADIOL 0.03 MG;
ETHINYL ESTRADIOL 0.5 MG;
ETHINYL ESTRADIOL 0.02 MG;
ETHINYL ESTRADIOL 0.05 MG;
ETHINYL ESTRADIOL 0.035 MG;
ETHINYL ESTRADIOL 0.01 MG;
ETHINYL ESTRADIOL 0.025 MG;
ETHINYL ESTRADIOL 0-35 MCG;
ETHINYL ESTRADIOL 0.015 MG;
ETHINYL ESTRADIOL 0.03-0.04 MG;
ETHINYL ESTRADIOL 0.25 MG;
{7 (Ethinyl Estradiol 0.035 MG / Norethindrone 0.5 MG Oral Tablet) / 7 (Ethinyl Estradiol 0.035 MG / Norethindrone 0.75 MG Oral Tablet) / 7 (Ethinyl Estradiol 0.035 MG / Norethindrone 1 MG Oral Tablet) / 7 (Inert Ingredients 1 MG Oral Tablet) } Pack [Necon 7/7/7 28 Day];
{21 (Ethinyl Estradiol 0.03 MG / Norgestrel 0.3 MG Oral Tablet) / 7 (Inert Ingredients 1 MG Oral Tablet) } Pack [Lo/Ovral 28 Day] | - 61. alpha 1 antitrypsin deficiency
- [autosomal recessive trait leading to destruction of lung tissue by neutrophil elastase and eventual emphysema; second only to cystic fibrosis as most common lethal genetic disorder among Caucasians of northern European ancestry. ( CSP )] (UMLS (CSP) C0221757) =Disease or Syndrome ;
=Connective Tissue Disease;
Congenital Metabolic Disorder |
- 12. (17alpha)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol
- [A semisynthetic estrogen. Metabolized by the liver to ethynyl estradiol, mestranol serves as the estrogen component in several combination oral contraceptives. (NCI04) ( NCI )] (UMLS (NCI) C0025506) =Steroid; Pharmacologic Substance =[HS300] ESTROGENS;
(17alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol =MESTRANOL 0.1 MG;
MESTRANOL 0.15 MG;
MESTRANOL 0.05 MG;
MESTRANOL 50 MCG | - 62. Alpha 1 Type I Collagen
- [Collagen I (Alpha 1), encoded by the COL1A1 gene, is the major component of type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (from LocusLink) ( NCI )] (UMLS (NCI) C0972255) COL1A1;
Collagen Alpha 1(I) Chain;
Collagen I (Alpha 1);
Collagen I, Alpha-1 Polypeptide;
Collagen of Skin, Tendon and Bone, Alpha-1 Chain;
Collagen of Skin, Tendon, and Bone, Alpha-1 Chain;
Collagen, Type I, Alpha 1;
Osteogenesis Imperfecta Type IV;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 13. (17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
- [A synthetic hormone that belongs to the family of drugs called androgens and is used to treat endometriosis. It is being evaluated in the treatment of endometrial cancer. ( NCI )] (UMLS (NCI) C0010961) =Steroid; Pharmacologic Substance =Pregnadienes;
[HS100] ANDROGENS/ANABOLICS =DANAZOL 100 MG;
DANAZOL 50 MG;
DANAZOL 200 MG;
| - 63. alpha 2 agonist
- [ ] (UMLS (CSP) C0599679) =Pharmacologic Substance
|
- 14. (1alpha,2alpha,3beta,4alpha,5alpha,6beta)1,2,3,4,5,6-Hexachlorocyclohexane
- [gamma isomer of benzene hexachloride, a carcinogenic insecticide more potent than DDT (chlorophenothane); it is used to kill lice and mites, applied topically to the skin. ( CSP )] (UMLS (NCI) C0005038) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
| - 64. Alpha 2 Interferon
- [A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli. Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04) ( NCI )] (UMLS (NCI) C0021734) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor =[IM700] IMMUNE STIMULANTS;
IFNa;
Interferon Type I, Recombinant;
Alpha 2 Interferon =Alpha 2 Interferon;
Interferon Alfa-2a 3000000 UNT/ML;
Interferon Alfa-2a 6000000 UNT/ML;
Interferon Alfa-2a 36000000 UNT/ML;
Interferon Alfa-2a 18000000 UNT;
INTERFERON ALFA-2A,RECOMBINANT 3 MILLION UNT/SYR;
INTERFERON ALFA-2A,RECOMBINANT 9 MILLION UNT/SYR;
INTERFERON ALFA-2A,RECOMBINANT 9MILLION UNT;
|
- 15. (1alpha,3beta,5Z,7E)-9,10-Secocholesta-3,7,10(19),16-tetraene-1,3,25-triol
- (UMLS (NCI) C0255545) =Steroid; Pharmacologic Substance ;
| - 65. Alpha 2 Type I Collagen
- [Collagen I (Alpha 2), encoded by the COL1A2 gene, is one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes. (from LocusLink) ( NCI )] (UMLS (NCI) C0766823) COL1A2;
Collagen Alpha 2(I) Chain;
Collagen I (Alpha 2);
Collagen I, Alpha-2;
Collagen of Skin, Tendon and Bone, Alpha-2 Chain;
Collagen of Skin, Tendon, and Bone, Alpha-2 Chain;
Collagen, Type I, Alpha-2 =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
|
- 16. (1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
- [most biologically active metabolite of cholecalciferol; acts via a DNA-binding steroid receptor which induces transcription of calcium transport factors in gut; USP drug (calcitriol) is given as an antihypocalcemic. ( CSP )] (UMLS (NCI) C0006674) =Steroid; Pharmacologic Substance; Hormone; Vitamin =(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol;
Dihydroxycholecalciferols;
[VT500] VITAMIN D;
steroid hormone =Calcipotriene;
(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol;
Calcitriol 0.00025 MG;
Calcitriol 0.0005 MG;
Calcitriol 0.001 MG/ML;
Calcitriol 0.002 MG/ML | - 66. Alpha 3 Type IV Collagen Precursor
- [Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C1314894) COL4A3;
COL4A3 Protein;
COL4A3BP Protein;
Collagen IV (Alpha 3);
Collagen IV, Alpha-3 Polypeptide;
Collagen of Basement Membrane, Alpha-3 Chain;
Collagen Type IV Alpha 3 Binding Protein;
Collagen, Type IV, Alpha 3 (Goodpasture Antigen);
EC 2.7.1.37;
Goodpasture Antigen;
GPBP Protein;
STARD11 Protein;
STAR-Related Lipid Transfer Protein 11;
START Domain-Containing Protein 11;
TUMSTATIN;
Tumstatin (Human Placenta Collagen Type IV alpha3 Chain NC1 Domain) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 17. (1alpha,3beta,5Z,7E)-9,10-Secostigmasta-5,7,10(19)-triene-1,3-diol
- (UMLS (NCI) C0534957) =Steroid ;
| - 67. Alpha 4 Protein
- [Ubiquitously expressed (highest in heart, skeletal muscle, and pancreas) by human IGBP1 Gene, 339-aa 39-kDa Immunoglobulin Binding Protein 1 is likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI) ( NCI )] (UMLS (NCI) C1334162) B Cell Signal Transduction Molecule Alpha 4;
CD79A-Binding Protein 1;
IGBP1;
Immunoglobulin (CD79A) Binding Protein 1;
Immunoglobulin Binding Protein 1 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 18. (1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
- [A substance that is being studied in the prevention of recurrent prostate cancer. It belongs to the family of drugs called vitamin D analogs. ( NCI )] (UMLS (NCI) C0043668) =Steroid; Pharmacologic Substance; Vitamin =Ergocalciferols;
[VT509] VITAMIN D, OTHER =Doxercalciferol 0.002 MG/ML;
DOXERCALCIFEROL 0.0025 MG;
| - 68. alpha actinin
- [cytoskeletal protein present in Z lines of muscle fibrils and at sites of non-muscle cell contact with a substrate. ( CSP )] (UMLS (CSP) C0917705) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
=ABP;
|
- 19. (2alpha,3beta)-2,3,23-Trihydroxyurs-12-en-28-oic acid, O-6-deoxy-alpha-L-mannopyranosyl-(1--4)--beta-D-glucopyranosyl-(1--6)-O-beta-D-glucopyranosyl Ester
- (UMLS (NCI) C0052506) =Organic Chemical; Pharmacologic Substance
| - 69. alpha adrenergic agent
- [drugs that selectively bind to and activate alpha adrenergic receptors. ( CSP )] (UMLS (CSP) C0178469) =Pharmacologic Substance =adrenergic agent;
|
- 20. (3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid
- [A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. ( NCI )] (UMLS (NCI) C0042105) =Steroid; Pharmacologic Substance; Biologically Active Substance =Deoxycholic Acid;
(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid;
[GA900] GASTRIC MEDICATIONS, OTHER;
=(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid;
URSODIOL 250 MG;
Ursodeoxycholate 300 MG | - 70. alpha adrenergic receptor
- [alpha-1 is coupled to phospholipase C, such that stimulation results in production of second messengers DAG and in inositol phosphates; alpha-2 is coupled to adenylate cyclase such that stimulation lowers cyclic AMP. ( CSP )] (UMLS (CSP) C0034784) =Amino Acid, Peptide, or Protein; Receptor ;
=adrenergic receptor;
|
- 21. (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
- [A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04) ( NCI )] (UMLS (NCI) C0077144) =Steroid; Pharmacologic Substance =Stanolone;
[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
TO BE DELETED INGREDIENT PREPARATIONS;
=TRILOSTANE 60 MG;
TRILOSTANE 30 MG;
| - 71. Alpha Adrenergic Receptor Gene
- [Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptor Genes encode Alpha Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. ( NCI )] (UMLS (NCI) C1332237) =Gene or Genome ;
|
- 22. (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride
- [The hydrochloride salt form of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the various opioid receptors in the central nervous system, including the mu-, kappa- and gamma-opioid receptors. This leads to an inhibition of the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naltrexone is longer-acting and more potent compared to naloxone. ( NCI )] (UMLS (NCI) C0355800) =Organic Chemical; Pharmacologic Substance =NALTREXONE;
=NALTREXONE HYDROCHLORIDE 50 MG | - 72. alpha aminoisobutyrate
- [ ] (UMLS (CSP) C0102457) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 23. (5alpha,17beta)-17-Hydroxyandrostan-3-one
- [potent androgenic metabolite of testosterone; dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone; unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. ( CSP )] (UMLS (NCI) C0038148) =Steroid; Pharmacologic Substance; Hormone =androgen;
Androstanols =(4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile | - 73. alpha amylase
- [An enzyme that catalyzes the endohydrolysis of 1,4-alpha-glycosidic linkages in starch, glycogen, and related polysaccharides and oligosaccharides containing 3 or more 1,4-alpha-linked D-glucose units. EC 3.2.1.1. ( MSH )] (UMLS (CSP) C0002245) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 24. (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
- [orally active testosterone 5-alpha reductase inhibitor, used as an alternative to surgery for treatment of benign prostatic hyperplasia. ( CSP )] (UMLS (NCI) C0060389) =Steroid; Pharmacologic Substance ;
=Androstenes;
[AN000] ANTINEOPLASTICS;
Azasteroids;
enzyme inhibitor;
[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
=FINASTERIDE 1 MG;
FINASTERIDE 5 MG | - 74. alpha carboxylase
- [also another name for EC 1.2.4.1, PYRUVATE DEHYDROGENASE, do not confuse. ( CSP )] (UMLS (CSP) C0034342) =Amino Acid, Peptide, or Protein; Enzyme ;
=carboxy lyase;
|
- 25. (5alpha,6alpha)-17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol Hydrochloride
- [The hydrochloride salt form of nalbuphine, a synthetic phenanthrene opioid with opiate agonist and antagonist effects, used to treat moderate to severe pain and provide preoperative and postoperative analgesia and sedation. Nalbuphine hydrochloride binds to kappa-, mu- and delta-opioid receptors but not to sigma-opioid receptors. This opioid exerts its analgesic actions primarily through kappa-opioid-receptor agonism and partially through mu-opioid receptor agonism. ( NCI )] (UMLS (NCI) C0600099) =Organic Chemical; Pharmacologic Substance =NALBUPHINE;
=NALBUPHINE HYDROCHLORIDE 20 MG/ML;
NALBUPHINE HYDROCHLORIDE 1.5 MG/ML;
NALBUPHINE HYDROCHLORIDE 10 MG/ML | - 75. alpha catenin
- [A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN. ( MSH )] (UMLS (CSP) C0108280) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 26. (6alpha)-17-(Acetyloxy)-6-methylpregn-4-ene-3,20-dione
- [A synthetic, acetate derivative of the sex hormone progesterone. Medroxyprogesterone 17-acetate (NCI04) ( NCI )] (UMLS (NCI) C0065864) =Steroid; Pharmacologic Substance; Hormone =(6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione;
=MEDROXYPROGESTERONE ACETATE 14 TABS X 5 MG;
MEDROXYPROGESTERONE ACETATE DAY15-28 X 5 MG;
MEDROXYPROGESTERONE ACETATE 5 MG;
MEDROXYPROGESTERONE ACETATE 2.5 MG;
MEDROXYPROGESTERONE ACETATE 100 MG/ML;
MEDROXYPROGESTERONE ACETATE 10 MG;
MEDROXYPROGESTERONE ACETATE 25 MG;
MEDROXYPROGESTERONE ACETATE 400 MG/ML;
MEDROXYPROGESTERONE ACETATE 150 MG/ML;
| - 76. alpha caveolin
- [ ] (UMLS (CSP) C0287872) =Amino Acid, Peptide, or Protein; Receptor
|
- 27. (6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
- [synthetic progestin derived from 17-hydroxyprogesterone; a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms. ( CSP )] (UMLS (NCI) C0025147) =Steroid; Pharmacologic Substance; Hormone =[HS800] PROGESTINS;
17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione;
progesterone analog;
=(6alpha)-17-(Acetyloxy)-6-methylpregn-4-ene-3,20-dione | - 77. Alpha Cell
- [A cell in the periphery of the pancreatic islets that secretes glucagon. ( NCI )] (UMLS (NCI) C0030280) =Cell ;
|
- 28. (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
- [synthetic glucocorticoid derived from progesterone, used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant. ( CSP )] (UMLS (NCI) C0025815) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione =(7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione;
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate;
METHYLPREDNISOLONE SODIUM SUCCINATE;
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate;
METHYLPREDNISOLONE SODIUM SUCCINATE;
METHYLPREDNISOLONE 2 MG;
METHYLPREDNISOLONE 24 MG;
METHYLPREDNISOLONE 32 MG;
METHYLPREDNISOLONE 8 MG;
METHYLPREDNISOLONE 16 MG;
METHYLPREDNISOLONE 4 MG | - 78. Alpha Cell Neoplasm
- [(GLOO-kuh-guh-NO-ma) A rare pancreatic tumor that produces a hormone called glucagon. Glucagonomas can produce symptoms similar to diabetes. ( NCI )] (UMLS (NCI) C0017689) =Neoplastic Process =Islet Cell Adenoma;
|
- 29. (6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
- [A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activity. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis. ( NCI )] (UMLS (NCI) C0016299) =Steroid; Pharmacologic Substance ;
=(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;
[DE200] ANTI-INFLAMMATORY, TOPICAL =FLUOCINONIDE 0.05 % | - 79. Alpha DNA polymerase
- [An enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis. ( NCI )] (UMLS (NCI) C0012888) =Amino Acid, Peptide, or Protein; Enzyme
|
- 30. (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
- [The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow. ( NCI )] (UMLS (NCI) C0016298) =Steroid; Pharmacologic Substance ;
=Pregnadienes;
Steroids, Fluorinated;
FLUOCINOLONE;
=(6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;
FLUNISOLIDE;
FLUOCINOLONE ACETONIDE PWDR,TOP;
FLUOCINOLONE ACETONIDE 0.2 %;
FLUOCINOLONE ACETONIDE 0.01 %;
FLUOCINOLONE ACETONIDE 0.025 %;
FLUOCINOLONE ACETONIDE 0.1 % | - 80. Alpha Fetoprotein Increased
- (UMLS (NCI) C0235971) =Finding
|
- 31. (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) Ester
- [The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. ( NCI )] (UMLS (NCI) C0117996) =Organic Chemical; Pharmacologic Substance =FLUTICASONE;
=FLUTICASONE PROPIONATE 50 MCG;
FLUTICASONE PROPIONATE 500 MCG;
FLUTICASONE PROPIONATE 50 MCG/ACTUAT;
FLUTICASONE PROPIONATE 0.05 %;
FLUTICASONE PROPIONATE 110 MCG/ACTUAT;
FLUTICASONE PROPIONATE 44 MCG/ACTUAT;
FLUTICASONE PROPIONATE 220 MCG/ACTUAT;
FLUTICASONE PROPIONATE 250 MCG;
FLUTICASONE PROPIONATE 100 MCG;
FLUTICASONE PROPIONATE 0.005 % | - 81. alpha fucosidase deficiency
- [lysosomal storage disease caused by defective alpha-L-fucosidase and accumulation of fucose containing glycoconjugates; clinical symptoms include psychomotor deterioration, growth retardation, hepatosplenomegaly, cardiomegaly, and seizures. ( CSP )] (UMLS (CSP) C0016788) =Disease or Syndrome ;
=Carbohydrate Metabolism, Inborn Errors;
inborn lysosomal enzyme disorder;
enzyme deficiency;
Lysosomal Storage Diseases, Nervous System |
- 32. (7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
- [The dipropionate salt form of alclometasone, a synthetic corticosteroid with low to medium potency. Alclometasone dipropionate is a glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory, immunosuppressive, antipruritic, and vasoconstrictive effects of natural glucocorticoids. This drug interacts with specific intracellular receptors and binds to DNA to modify gene expression. This results in an induction of synthesis of certain proteins while inhibiting the synthesis of others. Alclometasone dipropionate is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. (NCI05) ( NCI )] (UMLS (NCI) C0051113) =Steroid; Pharmacologic Substance ;
=(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;
ALCLOMETASONE =ALCLOMETASONE DIPROPIONATE 0.05 %;
| - 82. alpha galactosidase
- [hydrolyses terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids. ( CSP )] (UMLS (CSP) C0002268) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 33. (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
- [exhibits cytotoxic or antitumor properties; naturally derived from cultures of Streptomyces; inhibits protein kinase C. ( CSP )] (UMLS (NCI) C0075193) =Organic Chemical; Pharmacologic Substance ;
=alkaloid;
| - 83. alpha galactosidase deficiency
- [x-linked lysosomal storage disease of glycosphingolipid catabolism, resulting from a deficiency of alpha-galactosidase A and leading to accumulation of ceramide trihexoside in the cardiovascular and renal systems. ( CSP )] (UMLS (CSP) C0002986) =Disease or Syndrome
|
- 34. .alpha.-Linolenic acid
- [An essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostaglandin resulting in reduced inflammation and prevention of certain chronic diseases. ( NCI )] (UMLS (NCI) C0051405) =Lipid; Biologically Active Substance ;
=Fatty Acids, Omega-3;
Linolenic Acids =LINOLENIC ACID | - 84. alpha globulin
- [blood plasma or serum protein that is alkaline and has great electrophoretic mobility. ( CSP )] (UMLS (CSP) C0002211) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 35. 1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole
- [1-(alpha-methoxymethyl ethanol)-2-nitroimidazole; trichimonicide and experimental mutagen and radiosensitizer, probably due to its ability to form DNA-attacking free radical under hypoxic conditions. ( CSP )] (UMLS (NCI) C0026218) =Organic Chemical; Pharmacologic Substance =Antiprotozoal Agent;
imidazole;
Radiation Sensitizers;
| - 85. alpha glucosidase
- [hydrolyses terminal, non-reducing 1,4-linked alpha-D- glucose residues with release of alpha-D-glucose. ( CSP )] (UMLS (CSP) C0002272) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme
|
- 36. 16alpha-Fluoroandrost-5-en-17-one
- (UMLS (NCI) C0539515) =Steroid; Pharmacologic Substance ;
| - 86. Alpha Heavy Chain Disease
- [A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain. It predominantly affects young people in the Mediterranean region. It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever. There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells. The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma). Alpha heavy chain disease frequently progresses to large B-cell lymphoma, and normally has a poor prognosis. ( NCI )] (UMLS (NCI) C0021071) =Neoplastic Process ;
=HCD;
Intestinal Diseases;
lymphoma;
|
- 37. 17 Alpha-methyl-delta4-androsten-17beta-ol-4-one
- (UMLS (NCI) C1449554) =Steroid; Pharmacologic Substance
| - 87. alpha helix
- [A right-handed spiral conformation; the a-helix has a pitch of 5.4 A and has 3.6 amino acid residues per turn; every main chain C=O and N-H group is hydrogen-bonded to a peptide bond 4 residues away; the peptide planes are roughly parallel with the helix axis and the dipoles within the helix are aligned, i.e. all C=O groups point in the same direction and all N-H groups point the other way; side chains point outward from helix axis and are generally oriented towards its amino-terminal end. (from expasy.org) ( NCI )] (UMLS (CSP) C0599214) =Spatial Concept
|
- 38. 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione
- [principal progestational hormone, secreted by the corpus luteum, placenta, and in minute amounts by the adrenal cortex; it prepares the uterus for the reception and development of the fertilized ovum; it acts on the mammary glands and on the brain; it serves as an intermediate in the biosynthesis of sex steroids and adrenal corticosteroids. ( CSP )] (UMLS (NCI) C0033308) =Steroid; Pharmacologic Substance; Hormone =C21 steroid;
Pregnenediones;
[HS800] PROGESTINS;
gonadal steroid hormone =HYDROXYPROGESTERONE;
(6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione;
PROGESTERONE 2.5 MG;
PROGESTERONE 25 MG/ML;
PROGESTERONE 50 MG/ML;
PROGESTERONE 100 MG;
PROGESTERONE PWDR;
PROGESTERONE 200 MG;
PROGESTERONE 8 %;
PROGESTERONE 4 %;
| - 88. alpha hydroxyketone
- [ ] (UMLS (CSP) C0598751) =Organic Chemical ;
|
- 39. 1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-,(-)-tropate(ester)
- [anticholinergic alkaloid. ( CSP )] (UMLS (NCI) C0036442) =Organic Chemical; Pharmacologic Substance =alkaloid;
Belladonna Alkaloids;
1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-,(-)-tropate(ester);
tropane;
Anticholinergic Agent;
[CN550] ANTIVERTIGO AGENTS =1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-,(-)-tropate(ester);
Scopolamine Derivatives;
HYOSCINE HYDROBROMIDE;
SCOPOLAMINE 0.33 MG | - 89. Alpha Inhibin
- [The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. (LocusLink) ( NCI )] (UMLS (NCI) C0299209) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 40. 1alphaH,5alphaH-Tropanium, 6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-, bromide,(-)-tropate(8CI)
- [The bromide salt form of methscopolamine, a quaternary ammonium derivative of scopolamine with anticholinergic properties. Methscopolamine bromide exerts its effect on muscarine receptors in the gastrointestinal tract, thereby blocking the actions of acetylcholine. This leads to an inhibition of gastric secretions and gastrointestinal motility. ( NCI )] (UMLS (NCI) C0141756) =Organic Chemical; Pharmacologic Substance =METHSCOPOLAMINE;
=METHSCOPOLAMINE BROMIDE 2.5 MG | - 90. Alpha Interferon
- [A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04) ( NCI )] (UMLS (NCI) C0751598) alpha-Interferon;
Interferon Alfa;
Leukocyte Interferon;
Lymphoblast Interferon;
Lymphoblastoid Interferon;
Recombinant Interferon Alfa;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance |
- 41. 2 Alpha-Methyldihydrotestosterone Propionate
- [The propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness. (NCI) ( NCI )] (UMLS (NCI) C0058758) =Steroid; Pharmacologic Substance
| - 91. alpha ketoglutarate
- [intermediate in the Krebs' cycle; also produced from glutamate in amino group transfer reactions and by oxidative deamination. ( CSP )] (UMLS (CSP) C1291208) =Organic Chemical; Pharmacologic Substance =glutarate;
|
- 42. 2alpha,3beta,23-Trihydroxyurs-12-en-28-oic Acid
- (UMLS (NCI) C0081660) =Organic Chemical; Pharmacologic Substance ;
| - 92. alpha ketoglutarate dehydrogenase
- [component of a multi-enzyme complex which decarboxylates alpha ketoglutarate to form succinyl coA in the Krebs' cycle. ( CSP )] (UMLS (CSP) C0022626) =Amino Acid, Peptide, or Protein; Enzyme =aldehyde/ketone oxidoreductase;
respiratory enzyme |
- 43. 2alpha,3beta,6beta,23-Tetrahydroxyurs-12-en-28-oic Acid
- (UMLS (NCI) C0065501) =Organic Chemical; Pharmacologic Substance ;
| - 93. alpha L fucosidase
- [An enzyme that catalyzes the hydrolysis of an alpha L-fucoside to yield an alcohol and L-fucose. Deficiency of this enzyme can cause FUCOSIDOSIS. EC 3.2.1.51. ( MSH )] (UMLS (CSP) C0016787) =Amino Acid, Peptide, or Protein; Enzyme
|
- 44. 3.Alpha,4.Beta, 15-triol, 12, 13-epoxy-,4, 15-diacetate (8CI)
- [trichothecene mycotoxin produced by species of Fusarium that contaminate grain and other foodstuffs, causing fusariotoxicosis and hemorrhaging in livestock. ( CSP )] (UMLS (NCI) C0057671) =Organic Chemical; Pharmacologic Substance ;
=Fungal Toxin;
sesquiterpene | - 94. Alpha L Integrin Chain
- [Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink) ( NCI )] (UMLS (NCI) C0079091) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 45. 4,5-alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride
- [The hydrochloride salt form of oxymorphone, a semisynthetic opioid with a potent analgesic property. Oxymorphone hydrochloride binds to and activates opiate receptors, specifically mu-receptors, in the central nervous system (CNS). This results in sedation, analgesia, decreased gastrointestinal motility, and respiratory depression. ( NCI )] (UMLS (NCI) C0282275) =Organic Chemical; Pharmacologic Substance =OXYMORPHONE;
=OXYMORPHONE HYDROCHLORIDE 1 MG/ML;
OXYMORPHONE HYDROCHLORIDE 1.5 MG/ML;
OXYMORPHONE HYDROCHLORIDE 5 MG | - 95. alpha mannosidase
- [An enzyme that catalyzes the HYDROLYSIS of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. The enzyme plays a role in the processing of newly formed N-glycans and in degradation of mature GLYCOPROTEINS. There are multiple isoforms of alpha-mannosidase, each having its own specific cellular location and pH optimum. Defects in the lysosomal form of the enzyme results in a buildup of mannoside intermediate metabolites and the disease ALPHA-MANNOSIDOSIS. ( MSH )] (UMLS (CSP) C0051350) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 46. 4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride
- [The hydrochloride salt of oxycodone, a methylether of oxymorphone and semisynthetic opioid agonist with analgesic and antitussive properties. Oxycodone binds to mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opiates. In addition to analgesia and a depressive effect on the cough center in the medulla, this agent may cause euphoria, anxiolysis, miosis, sedation, physical dependence, constipation, and respiratory depression, depending on dosage and variations in individual metabolism. ( NCI )] (UMLS (NCI) C0282274) =Organic Chemical; Pharmacologic Substance =4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one;
=OXYCODONE HYDROCHLORIDE 5 MG;
OXYCODONE HYDROCHLORIDE 20 MG/ML;
OXYCODONE HYDROCHLORIDE 5 MG/5ML;
OXYCODONE HYDROCHLORIDE 20 MG;
OXYCODONE HYDROCHLORIDE 80 MG;
OXYCODONE HYDROCHLORIDE 160 MG;
OXYCODONE HYDROCHLORIDE 10 MG;
OXYCODONE HYDROCHLORIDE 40 MG;
OXYCODONE HYDROCHLORIDE 15 MG;
OXYCODONE HYDROCHLORIDE 2.5 MG;
OXYCODONE HYDROCHLORIDE 7.5 MG;
OXYCODONE HYDROCHLORIDE 30 MG;
OXYCODONE HYDROCHLORIDE 2.25 MG;
OXYCODONE HYDROCHLORIDE 4.5 MG;
| - 96. alpha methyl p tyrosine
- [An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed) ( MSH )] (UMLS (CSP) C0051427) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=Methyltyrosines;
|
- 47. 5 Alpha-Reductase Inhibitor
- [Substances that inhibit 5-alpha-Reductase, an enzyme that metabolizes testosterone to dihydrotestosterone, and can reduce prostate size. ( NCI )] (UMLS (NCI) C1318898) 5-alpha Reductase Inhibitors;
=Pharmacologic Substance ;
=enzyme inhibitor;
| - 97. alpha methyldopamine
- [decarboxylation product of the antihypertensive METHYLDOPA. ( CSP )] (UMLS (CSP) C0051413) =Organic Chemical =catecholamine;
|
- 48. 5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol Hydrochloride
- [The hydrochloride salt form of buprenorphine, a synthetic phenanthrene with narcotic analgesic activity. Buprenorphine hydrochloride is a partial agonist at the mu-opioid receptor and an antagonist at the kapa-opioid receptor in the central nervous system. However, under the conditions of recommended use it behaves as a classic mu-opioid agonist, mimicking the actions of endogenous peptides at CNS opioid receptors. The agonist action results in a raised pain threshold and increased tolerance to pain. However, it also causes sedation, physical dependence, and respiratory depressant effects and decreases heart rate and blood pressure. ( NCI )] (UMLS (NCI) C0701445) =Organic Chemical; Pharmacologic Substance ;
=buprenorphine;
=BUPRENORPHINE HYDROCHLORIDE 0.3 MG/ML;
BUPRENORPHINE HYDROCHLORIDE 2 MG;
BUPRENORPHINE HYDROCHLORIDE 8 MG | - 98. alpha N acetylglucosaminidase
- [ ] (UMLS (CSP) C0051437) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 49. 5alphaR
- [ ] (UMLS (CSP) C0599937) =Amino Acid, Peptide, or Protein; Enzyme
| - 99. Alpha Naphthyl Acetate Esterase Stain
- [A cytochemical staining technique to detect alpha-naphthyl acetate esterase (ANAE) activity. Nonspecific esterase stains with acetate substrate and is mainly used in the determination of lineage in acute myelogenous leukemia. Acute megakaryoblastic leukemia (M7) blasts stain strongly when the acetate substrate is used. ( NCI )] (UMLS (NCI) C1294078) Alpha Naphthyl Acetate Esterase Staining Method;
=Laboratory Procedure |
- 50. 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-Diacetate
- [The acetate salt form of diflorasone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE). Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes. ( NCI )] (UMLS (NCI) C0057992) =Steroid; Pharmacologic Substance ;
=BETAMETHASONE;
DIFLORASONE =DIFLORASONE DIACETATE 0.05 %;
| - 100. Alpha Naphthyl Butyrate Esterase Stain
- [A cytochemical staining technique to detect esterase enzyme contained within monocytes and macrophages, which reacts strongly with the substrate alpha-naphthyl butyrate. Monoblastic [FAB M5a (without differentiation) or M5b (with differentiation)] and acute myelomonocytic (M4) leukemias have staining in blasts when the butyrate substrate is employed. Myeloid cells (either malignant or non-malignant) do not stain with nonspecific esterase techniques. ( NCI )] (UMLS (NCI) C1293962) Alpha Naphthyl Butyrate Esterase Staining Method;
Alpha Naphthyl Esterase Stain;
Alpha Naphthyl Esterase Staining Method;
Butyrate-esterase stain =Laboratory Procedure =ObservationMethod;
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