- 2. alfalfa
- [plant species of the family Fabaceae widely cultivated for animal feed. ( CSP )] (UMLS (CSP) C0002022) =Plant
| - 5. alfentanil
- [An ultra short-acting, synthetic, opioid agonist with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to and stimulates the opiate receptors in the central nervous system (CNS), thereby mimicking the actions of endogenous opioids. Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of various neurotransmitters. The analgesic effect of alfentanil is likely due to the actions of its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability. ( NCI )] (UMLS (CSP) C0002026) =Organic Chemical; Pharmacologic Substance ;
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