- 2001. 60S Ribosomal Protein L10
- [Encoded by human RPL10 Gene (L10E Family), down-regulated during adipocyte, kidney, and heart differentiation, 213-aa 24-kDa cytoplasmic Ribosomal Protein L10 is a component of the ribosomal 60S subunit. Ribosomes catalyze protein synthesis and consist of 40S and 60S subunits composed of 4 rRNAs and approximately 80 structurally distinct proteins. RPL10 may also bind to and repress c-Jun transcriptional activation. (NCI) ( NCI )] (UMLS (NCI) C0218544) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2051. 70-79% BDY BRN/70-79% 3D
- [ ] (UMLS (ICD9CM) C0161370) =Injury or Poisoning
|
- 2002. 60S Ribosomal Protein L13
- [Encoded by human RPL13 Gene (L13E Ribosomal Protein Family), highly conserved 210-amino acid 24 kD cytoplasmic Ribosomal Protein L13 is a ribosomal 60S subunit protein. The protein is highly basic with no signal or transmembrane sequence, but has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0245587) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2052. 70-kD Heat Shock Protein
- [Heat Shock Protein 70 is a class of conserved molecular chaperone proteins in both prokaryotes and eukaryotic cells that may interact with polypeptides during the assembly processes to prevent the formation of nonfunctional structures. There are at least three HSP70 loci in the human genome, which map to chromosomes 6, 14, 21, and at least one other chromosome. Heat-shock proteins are expressed in response to a variety of stresses. The human HSP70 multi-gene family encodes highly conserved 70 kD proteins with structural and functional properties in common, but which vary in their response to metabolic stress. Some mRNAs are rapidly degraded through an AU-rich 3-prime untranslated region bound by AUF1, which complexes with HSC70, HSP70, EIF4G, and poly(A)-binding protein. The mRNA decay is associated with displacement of EIF4G from AUF1, ubiquitination of AUF1, and degradation. HSP70 blocks decay of AU-rich mRNAs and AUF1 protein. ( NCI )] (UMLS (NCI) C0243043) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 2003. 60S Ribosomal Protein L7a
- [Encoded by human RPL7A Gene (L7AE Family), 265-aa 30-kDa Ribosomal Protein L7a is a component of the large 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. (NCI) ( NCI )] (UMLS (NCI) C0073263) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2053. 70-kD Heat-Shock Protein/MUC-1 Antigen
- [A fusion protein of the MUC-1 colorectal cancer surface marker with HSP70 as a carrier. In trials as a cancer vaccine. ( NCI )] (UMLS (NCI) C0392929) =Therapeutic or Preventive Procedure ;
|
- 2004. 60S Ribosomal Protein L8
- [Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L8, encoded by the RPL8 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink) ( NCI )] (UMLS (NCI) C0169360) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 2054. 70% Ethanol
- [An aqueous dilution of ethanol containing 70% ethanol by volume. Used as a disinfecting agent and as a fixative. ( NCI )] (UMLS (NCI) C1381542) 70% Ethyl Alcohol;
Alcohol, Ethyl 70%;
ALCOHOL,ETHYL 70 %;
Ethyl Alcohol, 70% =Clinical Drug =Absolute ethanol;
=ALCOHOL, ETHYL 70% Topical liquid |
- 2005. 63-Desulfohirudin(Hirudo medicinalis isoform HV1)
- [A synthetic recombinant form of the naturally occurring hirudin, the anticoagulant substance found in leech. Desirudin is a selective and almost irreversible inhibitor of thrombin, both free and clot-bound, by blocking its active site. This anticoagulant agent has no effect on other components of the hemostatic system. Desirudin is particularly used to prevent deep vein thrombosis in patients undergoing hip and knee replacement surgery. ( NCI )] (UMLS (NCI) C0378366) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
| - 2055. 714-X
- [A product elaborated and marketed by the private Canadian laboratory. 714-X contains trimethylbicyclonitraminoheptane chloride, a nitrogenated camphor-derivative, and mineral salts in ethanol. It is claimed to cure cancer, multiple sclerosis, fibromyalgia, AIDS and other diseases by improving the body's immune function. Few inconclusive animal studies and no human trials were conducted with the product. There is no scientific evidence that 714-X is effective in treating any type of disease. It has not been proven to be safe or effective for any use. 714-X is banned by FDA for use in the USA. In Canada 714-X is legally available on compassionate grounds only through a licensed physician. ( NCI )] (UMLS (NCI) C0539517) =Organic Chemical; Pharmacologic Substance ;
|
- 2006. 65+ years old
- [elderly or aged humans of the age 65 or above; for a person older than 85, consider HUMAN VERY OLD AGE (85+) or CENTENARIAN (100+); also index with appropriate human and clinical research terms. ( CSP )] (UMLS (CSP) C0596728) =Age Group ;
=21+ years old;
=frail elderly;
85+ years old | - 2056. 72kD type IV Collagenase
- [Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (from LocusLink) ( NCI )] (UMLS (NCI) C0172537) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 2007. 6a
- [Maxillary right canine abutment ( HL7V3.0 )] (UMLS (HL7) C1553638) =Medical Device =Artificial dentition;
| - 2057. 76 kD Tyrosine Phosphoprotein
- [Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0296250) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 2008. 6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-Diacetate
- [The acetate salt form of diflorasone, a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. Like other glucocorticoids, diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm. The receptor complex subsequently translocates to the nucleus and activates or represses genes by interacting with short, palindromic DNA sequences called glucocorticoid response element (GRE). Gene activation leads to the exertion of anti-inflammatory effects, e.g. upregulation of IkappaB, while gene repression inhibits production of pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-2 and IL-6, thereby preventing activation of cytotoxic T-lymphocytes. ( NCI )] (UMLS (NCI) C0057992) =Steroid; Pharmacologic Substance ;
=BETAMETHASONE;
DIFLORASONE =DIFLORASONE DIACETATE 0.05 %;
| - 2058. 776C85
- (UMLS (NCI) C0650422) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
|
- 2009. 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with Acetone
- [A synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Flurandrenolide exerts its effects by interacting with specific cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions. ( NCI )] (UMLS (NCI) C0016374) =Steroid; Pharmacologic Substance; Hormone =Pregnenediones;
Steroids, Fluorinated;
[DE200] ANTI-INFLAMMATORY, TOPICAL;
=FLURANDRENOLIDE 4 MCG/SQC;
FLURANDRENOLIDE 0.05 %;
FLURANDRENOLIDE 0.025 %;
| - 2059. 776C85/5-FU
- [A combination tablet of ethynyluracil and fluorouracil. Fluorouracil is an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Ethynyluracil is an orally-active fluoropyrimidine analog that inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil in the liver. This may lead to an increase in the bioavailability and, effectiveness of fluorouracil. ( NCI )] (UMLS (NCI) C0393027) =Therapeutic or Preventive Procedure
|
- 2010. 6alpha-Methyl-11-oxoprogesterone
- [The basic, partial chemical structure of corticosteroid hormones such as cortisone and aldosterone. (NCI04) ( NCI )] (UMLS (NCI) C0099478) =Organic Chemical; Pharmacologic Substance ;
| - 2060. 776C85/CF/5-FU
- (UMLS (NCI) C0393028) =Therapeutic or Preventive Procedure
|
- 2011. 6H-furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,(2R(2alpha,3beta,3a beta,9a beta))
- [Congener of CYTARABINE that is metabolized to cytarabine and thereby maintains a more constant antineoplastic action. ( MSH )] (UMLS (NCI) C0010557) =Organic Chemical; Pharmacologic Substance ;
| - 2061. 7a
- [Maxillary right lateral incisor abutment ( HL7V3.0 )] (UMLS (HL7) C1553639) =Medical Device =Artificial dentition;
|
- 2012. 6H-Purine-6-thione, 2-amino-9-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-1,9-dihydro- (9CI)
- [A purine analog with potential antineoplastic activity. (NCI04) ( NCI )] (UMLS (NCI) C0051299) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 2062. 7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol
- [A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04) ( NCI )] (UMLS (NCI) C0935916) FULVESTRANT;
FULVESTRANT PREPARATION =Steroid; Pharmacologic Substance ;
=[AN500] ANTINEOPLASTIC HORMONES;
Unclassified Ingredients =FULVESTRANT 50 MG/ML;
|
- 2013. 6H-Pyrido[4, 3-b]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)
- [A derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis (NCI04) ( NCI )] (UMLS (NCI) C0100593) =Organic Chemical; Pharmacologic Substance ;
| - 2063. 7alpha hydroxylase
- [nonEC. ( CSP )] (UMLS (CSP) C0599930) =Amino Acid, Peptide, or Protein; Enzyme =Oxygenase;
|
- 2014. 6i
- [Maxillary right canine implant ( HL7V3.0 )] (UMLS (HL7) C1552170) =Medical Device =Artificial dentition;
| - 2064. 7B4 Antigen
- [Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2+)-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton. (from LocusLink, SWISS-PROT, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0300423) =Amino Acid, Peptide, or Protein; Immunologic Factor
|
- 2015. 6N HCL
- (UMLS (HL7) C1550070) =Biomedical or Dental Material; Inorganic Chemical ;
=Additive/Preservative;
| - 2065. 7E11-C5.3-GYK-DTPA
- [An immunoconjugate of the murine monoclonal antibody, 7E11-C5.3 (Capromab), conjugated to the linker-chelator, glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl). Capromab, an IgG1 kappa immunoglobulin, binds specifically to a cytoplasmic epitope of prostate-specific membrane glycoprotein (PSMA) that is only expressed by prostatic epithelial cells (benign and malignant). Capromab pendetide can be used in diagnostic or detection of prostate cancer when labeled with Indium I-111, which emits gamma radiation and X-Ray photons that can be captured by gamma camera allowing imaging of PMSA expressing tissues. ( NCI )] (UMLS (NCI) C0529572) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
|
- 2016. 6N HCL
- [A solution of HCl containing 6moles of hydrogen ion/L. Used as a Urine Preservative. ( HL7V3.0 )] (UMLS (HL7) C1561471) =Intellectual Product =MaterialEntityAdditive;
| - 2066. 7H-benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methyl
- [An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors. ( NCI )] (UMLS (NCI) C0217476) =Organic Chemical; Pharmacologic Substance ;
|
- 2017. 6p
- [Maxillary right canine prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553553) =Body Part, Organ, or Organ Component =Artificial dentition;
| - 2067. 7i
- [Maxillary right lateral incisor implant ( HL7V3.0 )] (UMLS (HL7) C1552171) =Medical Device =Artificial dentition;
|
- 2018. 6pd
- [Maxillary right canine distal prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553552) =Medical Device =Artificial dentition;
| - 2068. 7p
- [Maxillary right lateral incisor prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553556) =Body Part, Organ, or Organ Component =Artificial dentition;
|
- 2019. 6pm
- [Maxillary right canine mesial prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553554) =Medical Device =Artificial dentition;
| - 2069. 7pd
- [Maxillary right lateral incisor distal prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553555) =Medical Device =Artificial dentition;
|
- 2020. 6s
- [Supernumerary maxillary right canine ( HL7V3.0 )] (UMLS (HL7) C1552120) =Body Part, Organ, or Organ Component =SUPERNUMERARY TEETH;
| - 2070. 7pm
- [Maxillary right lateral incisor mesial prosthesis ( HL7V3.0 )] (UMLS (HL7) C1553557) =Medical Device =Artificial dentition;
|
- 2021. 7
- [Maxillary right lateral incisor ( HL7V3.0 )] (UMLS (HL7) C0227040) tooth 7 =Body Part, Organ, or Organ Component =Permanent dentition;
| - 2071. 7q
- [Distal (long) arm of chromosome 7 ( NCI )] (UMLS (NCI) C0796361) Chromosome 7 Distal Arm;
Chromosome 7 Long Arm;
Chromosome 7q =Nucleotide Sequence |
- 2022. 7 day report
- (UMLS (HL7) C1546921) =Temporal Concept =Report timing;
| - 2072. 7q31
- [A chromosome band present on 7q ( NCI )] (UMLS (NCI) C0796363) Chromosome 7q31 =Nucleotide Sequence
|
- 2023. 7 days
- (UMLS (HL7) C1547085) =Temporal Concept =Time delay post challenge;
| - 2073. 7s
- [Supernumerary maxillary right lateral incisor ( HL7V3.0 )] (UMLS (HL7) C1552121) =Body Part, Organ, or Organ Component =SUPERNUMERARY TEETH;
|
- 2024. 7 hours post challenge
- (UMLS (HL7) C1547086) =Temporal Concept =Time delay post challenge;
| - 2074. 8
- [Maxillary right central incisor ( HL7V3.0 )] (UMLS (HL7) C0227042) tooth 8 =Body Part, Organ, or Organ Component =Permanent dentition;
|
- 2025. 7 minutes post challenge
- (UMLS (HL7) C1547087) =Temporal Concept =Time delay post challenge;
| - 2075. 8 hours
- (UMLS (HL7) C1292429) =Temporal Concept ;
=Duration categories;
|
- 2026. 7(S)-Chloro-7-deoxylincomycin 2-phosphate
- [The phosphate salt form of clindamycin, a lincomycin antibiotic with antibacterial activity. Clindamycin phosphate is hydrolyzed in vivo to its active form clindamycin. Clindamycin exerts its bacteriostatic effect by binding to the 50S subunits of bacterial ribosomes, thereby interfering with peptidyl transferase activity in the elongation process of protein synthesis. As a result, this agent prevents bacterial cell growth. ( NCI )] (UMLS (NCI) C0055881) =Organic Chemical; Antibiotic ;
=7-Chloro-7-deoxylincomycin;
=7-Chloro-7-deoxylincomycin Hydrochloride;
Clindamycin Palmitate Hydrochloride;
CLINDAMYCIN PHOSPHATE MISC. POWDER (GM);
CLINDAMYCIN PHOSPHATE 2 %;
CLINDAMYCIN PHOSPHATE 150 MG/ML;
CLINDAMYCIN PHOSPHATE 6 MG/ML;
CLINDAMYCIN PHOSPHATE 18 MG/ML;
CLINDAMYCIN PHOSPHATE 1 %;
CLINDAMYCIN PHOSPHATE 12 MG/ML;
CLINDAMYCIN PHOSPHATE 2 MG/ML;
CLINDAMYCIN PHOSPHATE 9 MG/ML;
CLINDAMYCIN PHOSPHATE 100 MG;
| - 2076. 8 hours aligned on nursing shifts
- (UMLS (HL7) C1547089) =Temporal Concept =Time delay post challenge;
|
- 2027. 7,8-Didehydro-4,5-epoxy- 3-methoxy-17-methyl-(5a ,6a)-Morphinan-6-ol Sulfate (2:1)
- [The sulfate salt form of codeine, a naturally occurring phenanthrene alkaloid and opioid agonist with analgesic, antidiarrheal and antitussive activity. Codeine sulfate mimics the actions of opioids by binding to the opioid receptors at many sites within the central nervous system (CNS). Stimulation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This results in a decrease in intracellular cAMP and leads to a reduction in the release of neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline. The analgesic effect of codeine sulfate is likely due to its metabolite morphine, which induces opening of G-protein-coupled inwardly rectifying potassium (GIRK) channels and blocks the opening of N-type voltage-gated calcium channels, thereby resulting in hyperpolarization and reduced neuronal excitability. ( NCI )] (UMLS (NCI) C0304352) =Organic Chemical; Pharmacologic Substance =codeine;
=CODEINE SULFATE 10 MG;
CODEINE SULFATE 30 MG;
CODEINE SULFATE 10 MG/5ML;
CODEINE SULFATE 60 MG;
CODEINE SULFATE 15 MG | - 2077. 8 hours post challenge
- (UMLS (HL7) C1547088) =Temporal Concept =Time delay post challenge;
|
- 2028. 7,8-Dihydro-8-Oxoguanine Triphosphatase
- [Human 7,8-dihydro-8-oxoguanine triphosphatase protein (197 aa, 23 kD - unprocessed precursor) is encoded by the nudix (nucleoside diphosphate linked moiety X)-type motif 1 gene (NUDT1). Isoforms of this soluble protein are localized to both the cytoplasm and mitochondria of the cell. It catalyzes the hydrolysis of 8-oxo-dGTP to yield 8-oxo-dGMP and diphosphate. Misincorporation of 8-oxo-dGTP into DNA can result in A:T to C:G transversion mutations. Therefore, this enzyme is considered to be antimutagenic. ( NCI )] (UMLS (NCI) C0210507) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 2078. 8 minutes post challenge
- (UMLS (HL7) C1547090) =Temporal Concept =Time delay post challenge;
|
- 2029. 7-((4Z)-3-(Aminomethyl)-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)naphthyridine-3-carboxylic Acid Monomethanesulfonate
- [The mesylate salt form of gemifloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. This fluoroquinolone exerts an enhanced spectrum of activity against gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, in addition to its activity against gram-negative bacteria. ( NCI )] (UMLS (NCI) C1321744) Gemifloxacin Mesylate;
GEMIFLOXACIN MESYLATE PREPARATION =Organic Chemical; Pharmacologic Substance =GEMIFLOXACIN;
Unclassified Ingredients =GEMIFLOXACIN MESYLATE 320 MG | - 2079. 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt
- [A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. ( NCI )] (UMLS (NCI) C0813205) Sodium Suramin;
Suramin Hexasodium;
Suramin sodium =Organic Chemical; Pharmacologic Substance ;
|
- 2030. 7-(1-Methylethoxy)-3-phenyl-4H-1-benzopyran-4-one
- (UMLS (NCI) C0123903) =Organic Chemical; Pharmacologic Substance ;
| - 2080. 8-Aminoisoindolo(1,2-b)quinazolin-12(10H)-one
- [A water insoluble heterocyclic amide with potential antineoplastic activity. Batracylin appears to intercalate into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of batracylin is highly toxic and capable of inducing unscheduled DNA synthesis. This agent should, therefore, only be administered in patients with a slow acetylator NAT-2 genotype. ( NCI )] (UMLS (NCI) C0053006) =Organic Chemical; Pharmacologic Substance
|
- 2031. 7-(alpha-(4-Pyridylthio)acetamido)cephalosporanic acid sodium salt
- [The sodium salt form of cephapirin, a semi-synthetic, broad-spectrum, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephapirin sodium inhibits bacterial cell wall synthesis by inhibiting the final transpeptidation step of peptidoglycan synthesis and subsequent cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and leads to cell lysis. ( NCI )] (UMLS (NCI) C0085905) =Organic Chemical; Antibiotic =7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic Acid;
=cephapirin 1 gm injectable powder for injection | - 2081. 8-Azaguanine
- [A purine analogue with potential antineoplastic activity. 8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by competing with guanine for incorporation into tRNA catalyzed by the enzyme tRNA-guanine ribosyltransferase (tRNA-guanine transglycosylase). Altered guanine modification of tRNA has been implicated in cellular differentiation and neoplastic transformation. 8-Azaguanine also inhibits the formation of 43S and 80S initiation complexes, thereby interfering with initiation of translation and inhibiting protein synthesis. This agent inhibits tumor cell growth and stimulates cell differentiation. (NCI04) ( NCI )] (UMLS (NCI) C0004476) =Organic Chemical; Pharmacologic Substance
|
- 2032. 7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic Acid
- [Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms. ( MSH )] (UMLS (NCI) C0007737) =Organic Chemical; Antibiotic =Cephacetrile;
[AM101] CEPHALOSPORINS, 1ST GENERATION =7-(alpha-(4-Pyridylthio)acetamido)cephalosporanic acid sodium salt;
| - 2082. 8-Chloro Cyclic AMP
- [A substance that is being studied as an anticancer drug. It is an analogue of a substance that occurs naturally in the body (cyclic adenosine monophosphate). ( NCI )] (UMLS (NCI) C0050063) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
|
- 2033. 7-Allyl-8-oxoguanosine
- [A guanine ribonucleotide derivative with immunostimulatory and immunomodulatory activity. Loxoribine undergoes facilitated transport across the plasma membrane into the cytoplasmic compartment of the cell and acts intracellularly, bypassing the biochemical steps involved in the membrane signal transduction pathway used by Ag or anti-IgM Abs to activate B cells. This agent activates the Toll-like receptor 7 (TLR7), a member of the TLR family of pathogen-associated molecular pattern recognition receptors thereby activating the innate immune system. This activation requires endosomal maturation and recognition is restricted to TLR7. As a result, loxoribine induces cycling B cells to proliferate and differentiate non-specifically and recruit antigen-reactive B cells to undergo differentiation to antibody production, markedly amplifying the underlying response in the process. ( NCI )] (UMLS (NCI) C0209660) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance; Immunologic Factor
| - 2083. 8-Chloro-6-(2-fluorophenyl)-1-Methyl- 4H- Imidazo(1,5a)(1,4)Benzodiazepine
- [8-chloro-6-(2-fluorophenyl)-1-methyl- 4H- imidazo(1,5a)(1,4)benzodiazepine; short acting benzodiazepine sedative with high liability for abuse; used for preanesthesia sedation (USP lists as an injectable anesthetic). ( CSP )] (UMLS (NCI) C0026056) =Organic Chemical; Pharmacologic Substance =benzodiazepine;
[CN300] SEDATIVES/HYPNOTICS;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS;
=MIDAZOLAM HYDROCHLORIDE;
|
- 2034. 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- [benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action; its actions are mediated by enhancement of amma-aminobutyric acid activity; it is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. ( CSP )] (UMLS (NCI) C0012010) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
benzodiazepine;
Benzodiazepinones;
[CN300] SEDATIVES/HYPNOTICS;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS;
=DIAZEPAM 10 MG;
DIAZEPAM 15 MG;
DIAZEPAM 2 MG;
DIAZEPAM 5 MG/ML;
Diazepam 1 MG/ML;
DIAZEPAM 5 MG;
DIAZEPAM 2.5 MG;
DIAZEPAM 20 MG | - 2084. 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine
- [A triazolo-benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system (CNS). This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability. ( NCI )] (UMLS (NCI) C0014892) =Organic Chemical; Pharmacologic Substance =benzodiazepine;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS =ESTAZOLAM 1 MG;
ESTAZOLAM 2 MG |
- 2035. 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide
- [A semi-synthetic, broad-spectrum naphthacene antibiotic produced by the bacterium Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis. ( NCI )] (UMLS (NCI) C0011276) =Organic Chemical; Antibiotic =[AM250] TETRACYCLINES;
=7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride;
| - 2085. 8-Methoxypsoralen
- [A drug used in ultraviolet light therapy. ( NCI )] (UMLS (NCI) C0025684) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =Psoralens;
[DE801] ANTIPSORIATICS, SYSTEMIC;
[DE900] DERMATOLOGICALS, TOPICAL OTHER;
=METHOXSALEN 10 MG;
METHOXSALEN 1 %;
|
- 2036. 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
- [The hydrochloride salt form of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial activity. Demeclocycline hydrochloride binds reversibly to the 30S ribosomal subunit, thereby blocking the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex. This inhibits protein synthesis. In addition, this agent inhibits ADH-induced water reabsorption in the kidneys, thereby causing diuresis. ( NCI )] (UMLS (NCI) C0282125) =Organic Chemical; Antibiotic ;
=7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide;
=DEMECLOCYCLINE HYDROCHLORIDE 150 MG;
DEMECLOCYCLINE HYDROCHLORIDE 300 MG;
| - 2086. 8-methyl-6-piperidino-s-triazolo (4,3-b)Pyridazine
- (UMLS (NCI) C0078807) =Organic Chemical; Pharmacologic Substance
|
- 2037. 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one
- [7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one. ( CSP )] (UMLS (NCI) C0024002) =Organic Chemical; Pharmacologic Substance =benzodiazepine;
Benzodiazepinones;
tranquilizer;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS =LORAZEPAM 1 MG;
LORAZEPAM 2 MG;
LORAZEPAM 2 MG/ML;
LORAZEPAM 0.5 MG;
LORAZEPAM 4 MG/ML | - 2087. 8-MOP
- (UMLS (NCI) C0740123) =Organic Chemical; Pharmacologic Substance ;
|
- 2038. 7-Chloro-7-deoxylincomycin
- [A semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0008947) =Carbohydrate; Antibiotic =LINCOMYCIN;
[AM350] LINCOMYCINS;
[DE752] ANTIACNE AGENTS, TOPICAL;
[GU300] ANTI-INFECTIVES, VAGINAL =7(S)-Chloro-7-deoxylincomycin 2-phosphate;
7-Chloro-7-deoxylincomycin Hydrochloride;
Clindamycin Palmitate Hydrochloride;
| - 2088. 8-Oxo-2'-Deoxyguanosine
- [A type of altered DNA base caused by oxidative DNA damage. ( NCI )] (UMLS (NCI) C0081381) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance
|
- 2039. 7-Chloro-7-deoxylincomycin Hydrochloride
- [The hydrochloride salt form of clindamycin, a lincomycin antibiotic with antibacterial activity. Clindamycin hydrochloride exerts its antibacterial effect by binding to the 50S subunits of bacterial ribosomes, thereby interfering with peptidyl transferase activity in the elongation process of protein synthesis. As a result, this agent prevents bacterial cell growth. ( NCI )] (UMLS (NCI) C0282105) =Carbohydrate; Antibiotic ;
=7-Chloro-7-deoxylincomycin;
7(S)-Chloro-7-deoxylincomycin 2-phosphate =CLINDAMYCIN HYDROCHLORIDE 150 MG;
CLINDAMYCIN HYDROCHLORIDE 75 MG;
CLINDAMYCIN HYDROCHLORIDE 300 MG | - 2089. 8-Oxoguanine DNA Glycosylase
- [The protein 8-Oxoguanine DNA Glycosylase, encoded by the OGG1 gene, is an enzyme in base excision repair. OGG1 incises DNA at 8-oxoguanine residues and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 also has activities of beta-lyase that nicks DNA 3-prime to the lesion and endonuclease that cleaves DNA near apurinic or apyrimidinic sites to products with 5-prime-phosphate. Alternative splicing of the C-terminal region of the OGG1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common (1a/alpha, 1b, 1c, 2a/beta, 2b, 2c, 2d and 2e) and 1a is the prevalent form. OGG1 is ubiquitous and located in nucleus (isoform 1a) and mitochondria (isoform 2a). Defects in OGG1 are associated with tumor formation. ( NCI )] (UMLS (NCI) C1363852) N-Glycosylase/DNA Lyase;
OGG1 =Amino Acid, Peptide, or Protein; Enzyme |
- 2040. 7-Ethyl-10-Hydroxycamptothecin
- (UMLS (NCI) C0099808) =Organic Chemical; Pharmacologic Substance ;
| - 2090. 8-Oxoguanine DNA Glycosylase Gene
- [This gene is involved in base excision repair of oxidatively damaged DNA. ( NCI )] (UMLS (NCI) C1335081) OGG1;
OGG1 Gene;
=Gene or Genome ;
|
- 2041. 7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C
- (UMLS (NCI) C0099921) =Organic Chemical; Pharmacologic Substance ;
| - 2091. 80-89% BDY BRN/10-19% 3D
- [ ] (UMLS (ICD9CM) C0161373) =Injury or Poisoning
|
- 2042. 7-O-[(Methylthio)methyl]paclitaxel
- [An anticancer drug that belongs to the family of drugs called mitotic inhibitors. ( NCI )] (UMLS (NCI) C0796479) beta-(Benzoylamino)-a-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1H;
beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1H;
BMS-184476 =Organic Chemical; Pharmacologic Substance ;
| - 2092. 80-89% BDY BRN/20-29% 3D
- [ ] (UMLS (ICD9CM) C0161374) =Injury or Poisoning
|
- 2043. 70 kDa Ribosomal Protein S6 Kinase 2
- [Encoded by human RPS6KB2 Gene (S6 Ser/Thr Kinase Family), 482-aa 53-kDa Ribosomal Protein S6 Kinase Beta 2 specifically phosphorylates 40S ribosomal protein S6, the major eukaryotic ribosome substrate of many kinases. S6 phosphorylation is stimulated by growth factors and mitogens; dephosphorylation occurs at growth arrest. S6 may control cell growth and proliferation through the selective translation of specific of mRNA classes. (NCI) ( NCI )] (UMLS (NCI) C1138418) p70 Ribosomal S6 Kinase Beta;
p70 S6K Beta;
p70-Beta;
p70S6KB;
p70-S6KB;
Ribosomal Protein S6 Kinase Beta 2;
Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2;
RPS6KB2;
S6 Kinase-Related Kinase;
S6K2;
S6K-Beta 2;
Serine/Threonine-Protein Kinase 14 Beta;
SRK =Amino Acid, Peptide, or Protein; Enzyme | - 2093. 80-89% BDY BRN/3 DEG NOS
- [ ] (UMLS (ICD9CM) C0161372) =Injury or Poisoning
|
- 2044. 70-79% BDY BRN/10-19% 3D
- [ ] (UMLS (ICD9CM) C0161364) =Injury or Poisoning
| - 2094. 80-89% BDY BRN/30-39% 3D
- [ ] (UMLS (ICD9CM) C0161375) =Injury or Poisoning
|
- 2045. 70-79% BDY BRN/20-29% 3D
- [ ] (UMLS (ICD9CM) C0161365) =Injury or Poisoning
| - 2095. 80-89% BDY BRN/40-49% 3D
- [ ] (UMLS (ICD9CM) C0161376) =Injury or Poisoning
|
- 2046. 70-79% BDY BRN/3 DEG NOS
- [ ] (UMLS (ICD9CM) C0161363) =Injury or Poisoning
| - 2096. 80-89% BDY BRN/50-59% 3D
- [ ] (UMLS (ICD9CM) C0161377) =Injury or Poisoning
|
- 2047. 70-79% BDY BRN/30-39% 3D
- [ ] (UMLS (ICD9CM) C0161366) =Injury or Poisoning
| - 2097. 80-89% BDY BRN/60-69% 3D
- [ ] (UMLS (ICD9CM) C0161378) =Injury or Poisoning
|
- 2048. 70-79% BDY BRN/40-49% 3D
- [ ] (UMLS (ICD9CM) C0161367) =Injury or Poisoning
| - 2098. 80-89% BDY BRN/70-79% 3D
- [ ] (UMLS (ICD9CM) C0161379) =Injury or Poisoning
|
- 2049. 70-79% BDY BRN/50-59% 3D
- [ ] (UMLS (ICD9CM) C0161368) =Injury or Poisoning
| - 2099. 80-89% BDY BRN/80-89% 3D
- [ ] (UMLS (ICD9CM) C0161380) =Injury or Poisoning
|
- 2050. 70-79% BDY BRN/60-69% 3D
- [ ] (UMLS (ICD9CM) C0161369) =Injury or Poisoning
| - 2100. 85+ years old
- [elderly or aged humans of the age 85 or above; for a person older than 100 use the term CENTENARIAN (100+); also index with appropriate human and clinical research terms. ( CSP )] (UMLS (CSP) C0178694) =Age Group ;
=human old age (65+);
=100+ years old;
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