- 1. hSARA
- [Encoded by MADHIP Gene, ubiquitous cytoplasmic SARA contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Alternate isoforms represent full-length (1425-aa, 156-kD) or truncated protein (1210-aa and 762-aa). Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0761585) MAD (Mothers Against Decapentaplegic, Drosophila) Homolog Interacting Protein, Receptor Activation Anchor;
MADH-Interacting Protein;
MADHIP;
Mothers Against Decapentaplegic Homolog Interacting Protein;
Novel Serine Protease;
NSP;
Receptor Activation Anchor Protein;
SARA Protein;
SMAD Anchor for Receptor Activation =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| |
home
