- 1. Dual
- [Dual purpose. Defined purposes based on species and breed ( HL7V3.0 )] (UMLS (HL7) C1554184) =Intellectual Product =LivingSubjectProductionClass;
| - 7. Dual Specificity Phosphatase 22 Gene
- [This gene is involved in the inactivation of proteins which participate in cellular differentiation and proliferation. ( NCI )] (UMLS (NCI) C1423960) DUSP22;
DUSP22 Gene =Gene or Genome |
- 2. dual personality
- [ ] (UMLS (CSP) C0013259) =Mental or Behavioral Dysfunction
| - 8. Dual Specificity Phosphatase 3
- [Encoded by human DUSP3 Gene, 185-amino acid 20.5 kD conserved VH1-Related Phosphatase is a non-receptor member of the dual specificity protein phosphatase subfamily (Protein-Tyrosine Phosphatase Family) that inactivates target substrates by dephosphorylating phosphotyrosine and phosphoserine/threonine residues. Negative regulators of MAPK/ERK, SAPK/JNK, and p38 members associated with cellular proliferation and differentiation, dual specificity phosphatases show different tissue distributions and subcellular locations, distinct substrate specificities for MAP kinases, and different modes of induction by extracellular stimuli. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1333317) Dual Specificity Protein Phosphatase 3;
Dual Specificity Protein Phosphatase VHR;
DUSP3;
EC 3.1.3.16;
EC 3.1.3.48;
Serine/Threonine Specific Protein Phosphatase;
Vaccinia Virus Phosphatase VH1-Related;
VH1-Related Phosphatase;
=Amino Acid, Peptide, or Protein; Enzyme |
- 3. dual photon absorptiometry
- [ ] (UMLS (CSP) C0013260) =Diagnostic Procedure
| - 9. Dual Specificity Phosphatase 3 (Vaccinia Virus Phosphatase VH1-Related) Gene
- [This gene plays a role in the inactivation of proteins involved in cellular differentiation and proliferation. ( NCI )] (UMLS (NCI) C1333258) DUSP3;
DUSP3 Gene;
=Gene or Genome ;
|
- 4. Dual Purpose
- (UMLS (HL7) C1547278) =Intellectual Product =Production Class Code;
| - 10. Dual Specificity Protein Kinase TTK
- [Expressed as a 4-kb mRNA in proliferating cells by human TTK Gene (Ser/Thr Kinase Family), 841-aa 95-kDa TTK Protein Kinase is a likely dual-specificity kinase since it phosphorylates proteins on tyrosine as well as serine and threonine. TTK is probably associated with kinetochore or centrosome function in cell proliferation. Kinetochore-associated Mps1 kinase (Xenopus) is necessary to establish and maintain the mitotic checkpoint. Required for kinetochore recruitment and retention of active CENPE, Mps1 is necessary for Mad1 and Mad2 kinetochore association and inhibition of the Anaphase-Promoting Complex/Cyclosome. Mps1 (mouse), a Cdk2 substrate, regulates centrosome duplication jointly with Cdk2. By regulating Mps1 S phase stability, Cdk2 promotes centrosome duplication by Mps1. (NCI) ( NCI )] (UMLS (NCI) C1336689) ESK;
ESK Homologue;
Monopolar Spindle 1-Like 1;
MPS1L1;
Phosphotyrosine-Picked Threonine Kinase;
PYT;
TTK;
TTK Protein Kinase =Amino Acid, Peptide, or Protein; Enzyme |
- 5. DUAL SENSORY IMPAIRMENT
- [ ] (UMLS (ICD9CM) C1955602) =Disease or Syndrome
| - 11. Dual-Specificity Phosphoprotein Phosphatase
- [Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of signalling pathways that are involved in cell stress responses, proliferation and death. (from Nat Rev Drug Discov 2002;1:961-76) ( NCI )] (UMLS (NCI) C1333316) =Amino Acid, Peptide, or Protein; Enzyme
|
- 6. Dual Specificity Phosphatase 1
- [Dual Specificity Phosphatase 1, encoded by the DUSP1 gene, is induced by oxidative stress and heat shock. This protein specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. (from LocusLink and Swiss-Prot) ( NCI )] (UMLS (NCI) C0287531) =Amino Acid, Peptide, or Protein; Enzyme ;
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