HIV-1 TAT Interactive Protein 2, 30-kD

[Encoded by human HTATIP2 Gene (SDR Family), the ubiquitous 242-amino acid 30-kD TAT-Interacting Protein TIP30 is a nuclear and membrane-associated tumor suppressor that contains several conserved features: a semialdehyde dehydrogenase domain, a N-terminal beta-alpha-beta fold that may bind NADP(H), and a 20-amino acid N-terminal alpha helix that may enable protein docking. Proapoptotic TIP30 activity resides in the N-terminal domain. A 133-amino acid membrane-associated variant TC3 Protein contains a unique short C-terminus that confers antiapoptotic properties. TIP30 appears to be a RNA polymerase II transcription co-activator and may function as a co-activator for HIV-1 TAT protein. TIP30 may suppress metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1336577

HIV-1 TAT-Interacting Protein 30-kD
HTATIP2
HTATIP2 Protein
TAT-Interacting Protein (30kD)
TAT-Interacting Protein TIP30