Double Minute 2 Protein

[Inhibits p53 trans-activation, cell cycle arrest, and apoptosis. MDM2 binds p53 in the cell cycle at S/G2M phase and targets p53 for proteasome-mediated proteolysis. MDM2 also inhibits Rb protein and binds p14(ARF), ribosomal protein L5, and specifically to RNA. MDM2 gene expression is induced by DNA damage and regulated by the Ras-MAP kinase pathway. Some soft tissue sarcomas carry amplified MDM2 and overexpress MDM2 protein. (from SWISS-PROT Q00987, OMIM 164785, and NCI) ( NCI )]

UMLS (NCI) C0971008

HDM2
MDM 2 Protein
MDM2
MDM2 Protein
p53 Binding Protein
p53-Binding Protein MDM2
Ubiquitin-Protein Ligase E3 MDM2