[A respiratory stimulant with analeptic activity. Doxapram, independent of oxygen levels, directly stimulates the peripheral carotid chemoreceptors, possibly by inhibiting the potassium channels of type I cells within the carotid body, thereby stimulating catecholamines release. This results in the prevention or reversal of both narcotic- and CNS depressant-induced respiratory depression. ( NCI )]
UMLS (NCI) C0013084 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: Pyrrolidinones
[RE900] RESPIRATORY AGENTS, OTHER
Relation/CHD: 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone Monohydrochloride, Monohydrate