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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DB- DBA DBC DBD DBF DBH DBL DBS

DBL Oncoprotein

[Human DBL Oncoprotein is product of a mutated variant (Oncogene DBL) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Activated DBL oncogene is generated by 5-prime recombination with 3 (pter-p21) and by 3-prime recombination with 16 (p13-q22). The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. DBL Oncoprotein disrupts normal cell function. ( NCI )]
UMLS (NCI) C0069500
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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