- 1. c-mer Proto-oncogene Tyrosine Kinase
- [Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin by human MERTK Gene (AXL/UFO Family), 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK contains 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI) ( NCI )] (UMLS (NCI) C1259418) EC 2.7.1.112;
MERTK;
Receptor Tyrosine Kinase MerTK =Amino Acid, Peptide, or Protein; Enzyme; Receptor | - 3. C-MET
- [The MET proto-oncogene encodes hepatocyte growth factor receptor, a cell surface receptor-like tyrosine kinase comprised of disulfide-linked 50 kD (alpha) and 145 kD (beta) subunits. In the fully processed c-MET product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains, as well as sites of tyrosine phosphorylation. The beta subunit of the c-MET proto-oncogene product is the cell surface receptor for hepatocyte growth factor. c-MET is related to the insulin receptor and ABL oncogene. (from OMIM 164860 and NCI) ( NCI )] (UMLS (NCI) C1456828) Hepatocyte Growth Factor Receptor;
HGFR;
HGF-SF Receptor;
MET Gene Product =Amino Acid, Peptide, or Protein; Receptor |
- 2. C-MER Proto-Oncogene Tyrosine Kinase Gene
- [This gene plays a role in tissue homeostasis and mutations in the gene are associated with the onset of autosomal recessive retinitis pigmentosa. ( NCI )] (UMLS (NCI) C1364081) MERTK;
MERTK Gene =Gene or Genome | - 4. c-Met-related Tyrosine Kinase
- [A member of the MET receptor family. The protein is membrane-spanning disulfide-linked heterodimer with intracellular tyrosine kinase activity. It is synthesized as a single polypeptide which is processed to the 185-kD heterodimer of 35-kD (alpha) and 150-kD (beta) subunits joined by the predicted disulfide linkage. The protein is a specific cell surface receptor for macrophage stimulating protein. Targeted expression in mice results in frequent, multiple lung tumors. It may also play a role in progression of some colorectal cancers (from OMIM, Oncogene 2002;21:6382-6 and Oncogene 2003;22:186-97) ( NCI )] (UMLS (NCI) C0215510) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
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