- 1. 520C9x22 Bispecific Antibody
- [A partially humanized bivalent antibody targeting cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) against HER2/neu-overexpressing tumor cells. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody, 520C9, and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody, H22. While HER2/neu is overexpressed in a variety of malignancies, expression of Fc gammaRI is limited primarily to cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells. Therefore, HER2/neu expressing tumor cells bound by MDX-H210 can be selectively recognized by effector cells and triggers antibody-dependent cell-mediated cytotoxicity (ADCC), resulting in tumor cell lysis. ( NCI )] (UMLS (NCI) C0281736) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
| - 5. CXCL3
- [Chemokines are small, mostly basic, related molecules that regulate trafficking of leukocytes through interactions with GPCRs. There are two protein components of MIP1, alpha and beta. MIP-2 beta may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. MIP-2 beta expression studies indicate tissue-specific regulation as well as by specific agents, including IL-1, TNF, and lipopolysaccharide. (from OMIM 139111, Swiss-Prot P19876, and NCI) ( NCI )] (UMLS (NCI) C0208740) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 2. CX3C Chemokine
- [The last family member of chemokines is the CX3C (delta) chemokines. As the acronym suggests, there are three amino acids between the N-terminal cysteine residues. ( NCI )] (UMLS (NCI) C0751959) Delta Chemokine;
=Amino Acid, Peptide, or Protein; Immunologic Factor | - 6. CXCR
- [ ] (UMLS (CSP) C1328865) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 3. CXC Chemokine Ligand 7
- [A product of the PPBP gene, pro-platelet basic protein is processed into platelet basic protein (PBP) and connective-tissue-activating peptide III (CTAP-III). Upon platelet activation these proteins undergo further processing into beta thromboglobulin (Beta-TG) and neutrophil-activating peptide 2 (NAP2), respectively. Many of the function ascribed to CTAP-III may actually be the result of processing to NAP-2. ( NCI )] (UMLS (NCI) C1447076) PPBP;
Pro-Platelet Basic Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 7. CXPD
- [Encoded by human ERCC2 Gene (RAD3/XPD Family), 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2 is an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI) ( NCI )] (UMLS (NCI) C0168553) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 4. CXC Cytokine Gene
- [CXC Cytokine Genes encode Alpha Chemokines, CXC-type dual-cysteine chemokines with paired cysteine residues separated by a non-cysteine residue in their primary sequence that act as chemoattractants for neutrophils, but not for monocytes. (NCI) ( NCI )] (UMLS (NCI) C1332825) =Gene or Genome
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