c-mer Proto-oncogene Tyrosine Kinase

[Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin by human MERTK Gene (AXL/UFO Family), 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK contains 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI) ( NCI )]

UMLS (NCI) C1259418

EC 2.7.1.112
MERTK
Receptor Tyrosine Kinase MerTK