- 1. c-Myb
- [Encoded by human MYB Gene as 6 alternative isoforms, 640 aa 72-kDa nuclear c-MYB protein is a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. ( NCI )] (UMLS (NCI) C0072473) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 3. c-MYC Protein
- [Product of the c-myc proto-oncogene. A nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. ( NCI )] (UMLS (NCI) C0080065) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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