- 1. CCG1 Protein
- [Encoded by human TAF1 Gene, 1872-aa 250-kD nuclear TAF(II)250, the largest subunit of TFIID, may be phosphorylated by casein kinase II and contains an HMG box and two bromodomains with highly charged helical bundles that bind to diacetylated histone H4 tails. Variant 2 lacks 21 internal amino acids. Similar to Drosophila TAFII-230 and yeast TAFII-111 and TAF145, TAF1 contains N- and C-terminal Ser/Thr kinase domains that auto- and transphosphorylate the basal TFIIF large subunit. TAF1 possesses acetyl transferase activity, acts as an ubiquitin-conjugating enzyme, binds to core promoter transcription start sites, and interacts with TBP, other TAFs, and transcriptional regulators in TFIID assembly and RNA Pol II transcription initiation. Essential for G1 progression, TAF1 links control of transcription to the cell cycle. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C1146629) CCGS;
Cell Cycle Gene 1 Protein;
P250;
RNA Polymerase IIA 250kD;
TAF(II)250;
TAF1;
TAF1 RNA Polymerase II TATA Box Binding Protein;
TAF1 RNA Polymerase II TATA Box Binding Protein-Associated Factor 250-kD;
TAF2A;
TAFII250;
TATA Box Binding Protein;
TATA Box-Binding Protein-Associated Factor 2A;
TBP-Associated Factor;
TBP-Associated Factor 1;
TBP-Associated Factor 250 kDa;
TBP-Associated Factor RNA Polymerase II 250-kD;
TBP-Associated Factor, Class II, 250 kDa;
TF2D;
TFIID;
Transcription Factor IID;
Transcription Factor TFIID p250 Polypeptide;
Transcription Initiation Factor TFIID 250 kDa Subunit =Amino Acid, Peptide, or Protein; Biologically Active Substance | |
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