- 1. CCK
- [peptide secreted by the upper intestinal mucosa and also found in the central nervous system; causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions; cholecystokinin may be a mediator of satiety. ( CSP )] (UMLS (CSP) C0008328) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine; Hormone =gastrointestinal hormone;
neuropeptide;
Peptides;
gastric juice inhibitor =1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein | - 3. CCK4
- [Expressed in lung, liver, pancreas, kidney, placenta, melanocytes, thyroid gland, ovary, brain, heart, and skeletal muscle (but not in colon) by human PTK7 Gene (INSR family), 1070-aa 118-kDa (precursor) PTK7 Protein Tyrosine Kinase 7 is a type I membrane protein containing 7 Ig-like C2-type domains that appears to lack tyrosine kinase catalytic activity and may function as a cell adhesion molecule. PTK7 may be a colon carcinoma tumor progression marker. (NCI) ( NCI )] (UMLS (NCI) C0384197) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 2. CCK-B Receptor
- [Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. Cholecystokinin B Receptor (CCKBR), encoded by the CCKBR gene, is a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI) ( NCI )] (UMLS (NCI) C0248266) =Amino Acid, Peptide, or Protein; Receptor ;
| - 4. CCKBR
- [This gene plays a role in the modulation of regulatory peptides in the brain and gastrointestinal tract. ( NCI )] (UMLS (NCI) C1332675) CCKBR Gene;
Cholecystokinin B Receptor Gene =Gene or Genome |
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