CCG1 Protein

[Encoded by human TAF1 Gene, 1872-aa 250-kD nuclear TAF(II)250, the largest subunit of TFIID, may be phosphorylated by casein kinase II and contains an HMG box and two bromodomains with highly charged helical bundles that bind to diacetylated histone H4 tails. Variant 2 lacks 21 internal amino acids. Similar to Drosophila TAFII-230 and yeast TAFII-111 and TAF145, TAF1 contains N- and C-terminal Ser/Thr kinase domains that auto- and transphosphorylate the basal TFIIF large subunit. TAF1 possesses acetyl transferase activity, acts as an ubiquitin-conjugating enzyme, binds to core promoter transcription start sites, and interacts with TBP, other TAFs, and transcriptional regulators in TFIID assembly and RNA Pol II transcription initiation. Essential for G1 progression, TAF1 links control of transcription to the cell cycle. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1146629

CCGS
Cell Cycle Gene 1 Protein
P250
RNA Polymerase IIA 250kD
TAF(II)250
TAF1
TAF1 RNA Polymerase II TATA Box Binding Protein
TAF1 RNA Polymerase II TATA Box Binding Protein-Associated Factor 250-kD
TAF2A
TAFII250
TATA Box Binding Protein
TATA Box-Binding Protein-Associated Factor 2A
TBP-Associated Factor
TBP-Associated Factor 1
TBP-Associated Factor 250 kDa
TBP-Associated Factor RNA Polymerase II 250-kD
TBP-Associated Factor, Class II, 250 kDa
TF2D
TFIID
Transcription Factor IID
Transcription Factor TFIID p250 Polypeptide
Transcription Initiation Factor TFIID 250 kDa Subunit

Amino Acid, Peptide, or Protein
Biologically Active Substance

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