[inhibitors of the enzyme, dihydrofolate reductase, which converts dihydrofolate to tetrahydrofolate; frequently used in cancer chemotherapy. ( CSP )]
UMLS (NCI) C0016411 Relation/PAR: antimetabolite
Inhibitors, Nucleic Acid Synthesis
vitamin antagonist
Relation/CHD: 4-Aminofolic acid
4-Amino-10-methylfolic Acid
Thymidylate Synthase Inhibitor
DHFR Inhibitor