- 1. ANPB
- [Expressed in heart and vasculature by human NPR2 Gene (Guanylyl Cyclase Family), type I integral membrane protein Natriuretic Peptide Receptor B is the primary receptor for C-type natriuretic peptides that cause natriuresis, sodium excretion in the urine. NPR2 contains an extracellular ligand-binding domain, a membrane-spanning region, and an intracellular protein kinase homology domain, oligomerizing helical hinge region, and a C-terminal guanylyl cyclase catalytic domain activated upon receptor ligand binding. NPR2 seems to be more effectively stimulated by BNP than by ANP. NPR1 and NPR2 are ANP receptors with guanylate cyclase activity; NPR3 is probably responsible for ANP clearance from the circulation without a role in signal transduction. (NCI) ( NCI )] (UMLS (NCI) C0530295) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
| |
home
